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• W2795857067 abstract "Dendritic cells (DCs) trigger CD8 + T cell responses after the internalization of exogenous antigens in a process called cross-presentation. Multiple intracellular transport events within the endocytic and secretory routes take place in order to accomplish this fundamental immunological process. The endomembrane system can be envisioned as a complex network of membrane domains coordinately working in the fusion of organelles, the budding of vesicles and tubules, and modifying the molecular composition of the limiting membranes. In this context of tightly regulated and dynamic endomembrane transport, small GTPases of the Rab family display a pivotal role by organizing membrane microdomains and defining specific identities to the different intracellular compartments. In this review, we synthesize and update the current knowledge about Rab22a, which has been involved in several immune functions. In this way, we analyze the intracellular localization of Rab22a and its important role in the endocytic recycling, including its relevance during MHC-I trafficking, antigen cross-presentation by DCs and the formation of T cell conjugates. We also describe how different pathogenic microorganisms hijack Rab22a functions to achieve efficient infection and intracellular survival strategies. Furthermore, we examine the oncogenic properties of Rab22a and how its expression determines the progression of many tumors. In summary, we highlight the role of Rab22a as a key effector of the intracellular trafficking that could be exploited in future therapies to modulate the immune system." @default.
• W2795857067 created "2018-04-13" @default.
• W2795857067 creator A5036250995 @default.
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• W2795857067 date "2019-09-01" @default.
• W2795857067 modified "2023-10-08" @default.
• W2795857067 title "Rab22a: A novel regulator of immune functions" @default.
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• W2795857067 doi "https://doi.org/10.1016/j.molimm.2018.03.028" @default.
• W2795857067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29631761" @default.
• W2795857067 hasPublicationYear "2019" @default.
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