FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795857566> ?p ?o ?g. }

• W2795857566 endingPage "1203" @default.
• W2795857566 startingPage "1196" @default.
• W2795857566 abstract "OBJECTIVE To examine whether dipeptidyl peptidase 4 inhibitors (DPP-4I) increase acute pancreatitis risk in older patients and whether the association varies by age, sex, and history of cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS We conducted a cohort study of DPP-4I initiators versus thiazolidinedione (TZD) or sulfonylurea initiators using U.S. Medicare beneficiaries, 2007–2014. Eligible initiators were aged 66 years or older without history of pancreatic disease or alcohol-related diseases. Patients were followed up for hospitalization due to acute pancreatitis and censored at 90 days after treatment changes. Weighted Cox models were used to estimate the hazard ratio (HR) for acute pancreatitis. Analyses were performed overall as well as within subgroups defined by age, sex, and CVD history. RESULTS We found no increased risk of acute pancreatitis comparing 49,374 DPP-4I initiators to 132,223 sulfonylurea initiators (weighted HR 1.01; 95% CI 0.83–1.24) and comparing 57,301 DPP-4I initiators to 32,612 TZD initiators (weighted HR 1.11; 95% CI 0.76–1.62). Age and sex did not modify the association. Among patients with CVD, acute pancreatitis incidence was elevated in initiators of DPP-4I and sulfonylurea (2.3 and 2.4 per 1,000 person-years, respectively) but not in TZD initiators (1.5). Among patients with CVD, higher risk of acute pancreatitis was observed with DPP-4I compared with TZD (weighted HR 1.84; 95% CI 1.02–3.35) but not compared with sulfonylurea. CONCLUSIONS Our study provides evidence that DPP-4I is not associated with an increased risk of acute pancreatitis in older adults overall. The positive association observed in patients with CVD could be due to chance or bias but merits further investigation." @default.
• W2795857566 created "2018-04-13" @default.
• W2795857566 creator A5036291591 @default.
• W2795857566 creator A5040182038 @default.
• W2795857566 creator A5043069598 @default.
• W2795857566 creator A5065844636 @default.
• W2795857566 creator A5071146370 @default.
• W2795857566 date "2018-04-04" @default.
• W2795857566 modified "2023-09-26" @default.
• W2795857566 title "The Risk of Acute Pancreatitis After Initiation of Dipeptidyl Peptidase 4 Inhibitors: Testing a Hypothesis of Subgroup Differences in Older U.S. Adults" @default.
• W2795857566 cites W1571995743 @default.
• W2795857566 cites W1769338686 @default.
• W2795857566 cites W1842411015 @default.
• W2795857566 cites W1849521086 @default.
• W2795857566 cites W1913436710 @default.
• W2795857566 cites W1965355599 @default.
• W2795857566 cites W1969969418 @default.
• W2795857566 cites W1970638723 @default.
• W2795857566 cites W1977379410 @default.
• W2795857566 cites W1982080088 @default.
• W2795857566 cites W1983616459 @default.
• W2795857566 cites W1984486655 @default.
• W2795857566 cites W1986085856 @default.
• W2795857566 cites W2001477956 @default.
• W2795857566 cites W2028272916 @default.
• W2795857566 cites W2035655846 @default.
• W2795857566 cites W2064130493 @default.
• W2795857566 cites W2081932595 @default.
• W2795857566 cites W2085862152 @default.
• W2795857566 cites W2098931866 @default.
• W2795857566 cites W2108233388 @default.
• W2795857566 cites W2109312821 @default.
• W2795857566 cites W2110201971 @default.
• W2795857566 cites W2115024823 @default.
• W2795857566 cites W2127854619 @default.
• W2795857566 cites W2131964379 @default.
• W2795857566 cites W2136259411 @default.
• W2795857566 cites W2142830692 @default.
• W2795857566 cites W2152211963 @default.
• W2795857566 cites W2156288479 @default.
• W2795857566 cites W2164535707 @default.
• W2795857566 cites W2320979191 @default.
• W2795857566 cites W2344377042 @default.
• W2795857566 cites W2477411371 @default.
• W2795857566 cites W2519976593 @default.
• W2795857566 cites W2531128660 @default.
• W2795857566 cites W4214911496 @default.
• W2795857566 cites W4230892627 @default.
• W2795857566 cites W4242364069 @default.
• W2795857566 doi "https://doi.org/10.2337/dc17-2212" @default.
• W2795857566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5961396" @default.
• W2795857566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29618573" @default.
• W2795857566 hasPublicationYear "2018" @default.
• W2795857566 type Work @default.
• W2795857566 sameAs 2795857566 @default.
• W2795857566 citedByCount "4" @default.
• W2795857566 countsByYear W27958575662018 @default.
• W2795857566 countsByYear W27958575662019 @default.
• W2795857566 countsByYear W27958575662021 @default.
• W2795857566 countsByYear W27958575662022 @default.
• W2795857566 crossrefType "journal-article" @default.
• W2795857566 hasAuthorship W2795857566A5036291591 @default.
• W2795857566 hasAuthorship W2795857566A5040182038 @default.
• W2795857566 hasAuthorship W2795857566A5043069598 @default.
• W2795857566 hasAuthorship W2795857566A5065844636 @default.
• W2795857566 hasAuthorship W2795857566A5071146370 @default.
• W2795857566 hasBestOaLocation W27958575661 @default.
• W2795857566 hasConcept C120665830 @default.
• W2795857566 hasConcept C121332964 @default.
• W2795857566 hasConcept C126322002 @default.
• W2795857566 hasConcept C134018914 @default.
• W2795857566 hasConcept C156490143 @default.
• W2795857566 hasConcept C187960798 @default.
• W2795857566 hasConcept C201903717 @default.
• W2795857566 hasConcept C207103383 @default.
• W2795857566 hasConcept C2775967933 @default.
• W2795857566 hasConcept C2776670229 @default.
• W2795857566 hasConcept C2777180221 @default.
• W2795857566 hasConcept C2778763485 @default.
• W2795857566 hasConcept C2778854520 @default.
• W2795857566 hasConcept C2779284873 @default.
• W2795857566 hasConcept C2779306644 @default.
• W2795857566 hasConcept C44249647 @default.
• W2795857566 hasConcept C555293320 @default.
• W2795857566 hasConcept C61511704 @default.
• W2795857566 hasConcept C71924100 @default.
• W2795857566 hasConcept C90924648 @default.
• W2795857566 hasConceptScore W2795857566C120665830 @default.
• W2795857566 hasConceptScore W2795857566C121332964 @default.
• W2795857566 hasConceptScore W2795857566C126322002 @default.
• W2795857566 hasConceptScore W2795857566C134018914 @default.
• W2795857566 hasConceptScore W2795857566C156490143 @default.
• W2795857566 hasConceptScore W2795857566C187960798 @default.
• W2795857566 hasConceptScore W2795857566C201903717 @default.
• W2795857566 hasConceptScore W2795857566C207103383 @default.
• W2795857566 hasConceptScore W2795857566C2775967933 @default.
• W2795857566 hasConceptScore W2795857566C2776670229 @default.
• W2795857566 hasConceptScore W2795857566C2777180221 @default.

• next