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- W2795953807 endingPage "21" @default.
- W2795953807 startingPage "13" @default.
- W2795953807 abstract "CD4 T cells play a multiplicity of roles in protective immunity to influenza. Included in these functions are help for high affinity antibody production, enhancement of CD8 T cell expansion, function and memory, acceleration of the early innate response to infection and direct cytotoxicity. The influenza-specific CD4 T cell repertoire in humans established through exposures to infection and vaccination has been found to be highly variable in abundance, specificity and functionality. Deficits in particular subsets of CD4 T cells recruited into the response result in diminished antibody responses and protection from infection. Therefore, improved strategies for vaccination should include better methods to identify deficiencies in the circulating CD4 T cell repertoire, and vaccine constructs that increase the representation of CD4 T cells of the correct specificity and functionality." @default.
- W2795953807 created "2018-04-13" @default.
- W2795953807 creator A5005095813 @default.
- W2795953807 creator A5053826971 @default.
- W2795953807 creator A5074802230 @default.
- W2795953807 date "2018-08-01" @default.
- W2795953807 modified "2023-09-24" @default.
- W2795953807 title "Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus" @default.
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