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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795955478> ?p ?o ?g. }

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• W2795955478 abstract "A novel one-bead one-compound (OBOC) dual ring-opening/cleavage approach for cyclic peptide sequencing was developed. The method selectively modifies serine, cysteine, threonine, and/or glutamic acid to an oxazolidinone-derived moiety, thereby increasing the susceptibility of the modified peptide backbone toward hydrolysis. The resulting linear peptide was then sequenced in 1 min by tandem mass spectrometry on a quadrupole time-of-flight instrument incorporating two-dimensional liquid chromatography and ion mobility spectrometry separation. To evaluate this approach, a library of cyclic peptides was successfully sequenced with 98% overall accuracy, demonstrating its robustness and broad substrate scope." @default.
• W2795955478 created "2018-04-13" @default.
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• W2795955478 date "2018-04-04" @default.
• W2795955478 modified "2023-10-17" @default.
• W2795955478 title "Oxazolidinone-Mediated Sequence Determination of One-Bead One-Compound Cyclic Peptide Libraries" @default.
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• W2795955478 doi "https://doi.org/10.1021/acs.orglett.8b00717" @default.
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