FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2795961830> ?p ?o ?g. }

• W2795961830 abstract "Biomarkers of biological aging - DNA methylation age (DNAm age) and leukocyte telomere length (LTL)- correlate strongly with chronological age across the life course. It is, however, unclear how these measures of cellular wear and tear are associated with muscle strength and functional capacity, which are known to decline with older age and are associated with mortality. We investigated if DNAm age and LTL were associated with body composition and physical functioning by examining 48 monozygotic twin sisters.White blood cell DNAm age (predicted years) was calculated from Illumina 450 k BeadChip methylation data using an online calculator. DNAm age acceleration was defined from the residuals derived from a linear regression model of DNAm age on chronological age. LTL was measured by qPCR. Total body percentage of fat and lean mass were estimated using bioimpedance. Physical functioning was measured by grip strength, knee extension strength and by 10 m maximal walking speed test.In all participants, DNAm age (58.4 ± 6.6) was lower than chronological age (61.3 ± 5.9 years). Pairwise correlations of monozygotic co-twins were high for DNAm age (0.88, 95% CI 0.79, 0.97), age acceleration (0.68, 95% CI 0.30, 0.85) and LTL (0.77, 95% CI 0.60, 0.94). Increased age acceleration i.e. faster epigenetic aging compared to chronological age was associated with lower grip strength (β = - 5.3 SE 1.9 p = 0.011), but not with other measures of physical functioning or body composition. LTL was not associated with body composition or physical functioning.To conclude, accelerated DNAm age is associated with lower grip strength, a biomarker known to be associated with physiological aging, and which predicts decline in physical functioning and mortality. Further studies may clarify whether epigenetic aging explains the decline in muscle strength with aging or whether DNAm age just illustrates the progress of aging." @default.
• W2795961830 created "2018-04-13" @default.
• W2795961830 creator A5002275174 @default.
• W2795961830 creator A5014881388 @default.
• W2795961830 creator A5024496950 @default.
• W2795961830 creator A5028233802 @default.
• W2795961830 creator A5043098809 @default.
• W2795961830 creator A5054534903 @default.
• W2795961830 creator A5066655787 @default.
• W2795961830 creator A5089925493 @default.
• W2795961830 date "2018-04-04" @default.
• W2795961830 modified "2023-10-15" @default.
• W2795961830 title "Biological clocks and physical functioning in monozygotic female twins" @default.
• W2795961830 cites W133663607 @default.
• W2795961830 cites W157594672 @default.
• W2795961830 cites W1974047233 @default.
• W2795961830 cites W2000059391 @default.
• W2795961830 cites W2036395225 @default.
• W2795961830 cites W2037986780 @default.
• W2795961830 cites W2039153962 @default.
• W2795961830 cites W2042328858 @default.
• W2795961830 cites W2047783882 @default.
• W2795961830 cites W2058048665 @default.
• W2795961830 cites W2058108472 @default.
• W2795961830 cites W2072130124 @default.
• W2795961830 cites W2100703140 @default.
• W2795961830 cites W2101489273 @default.
• W2795961830 cites W2105735952 @default.
• W2795961830 cites W2107874655 @default.
• W2795961830 cites W2110405237 @default.
• W2795961830 cites W2113649341 @default.
• W2795961830 cites W2114602252 @default.
• W2795961830 cites W2124142246 @default.
• W2795961830 cites W2126384545 @default.
• W2795961830 cites W2127196115 @default.
• W2795961830 cites W2129411141 @default.
• W2795961830 cites W2129430399 @default.
• W2795961830 cites W2138404417 @default.
• W2795961830 cites W2143471290 @default.
• W2795961830 cites W2145859123 @default.
• W2795961830 cites W2150751047 @default.
• W2795961830 cites W2158245724 @default.
• W2795961830 cites W2188707104 @default.
• W2795961830 cites W2281263309 @default.
• W2795961830 cites W2290343632 @default.
• W2795961830 cites W2293934762 @default.
• W2795961830 cites W2336855366 @default.
• W2795961830 cites W2419143956 @default.
• W2795961830 cites W2421283105 @default.
• W2795961830 cites W2551442502 @default.
• W2795961830 cites W2588144476 @default.
• W2795961830 cites W2607464515 @default.
• W2795961830 cites W2952009394 @default.
• W2795961830 cites W4255365317 @default.
• W2795961830 doi "https://doi.org/10.1186/s12877-018-0775-6" @default.
• W2795961830 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5883300" @default.
• W2795961830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29614968" @default.
• W2795961830 hasPublicationYear "2018" @default.
• W2795961830 type Work @default.
• W2795961830 sameAs 2795961830 @default.
• W2795961830 citedByCount "20" @default.
• W2795961830 countsByYear W27959618302019 @default.
• W2795961830 countsByYear W27959618302020 @default.
• W2795961830 countsByYear W27959618302021 @default.
• W2795961830 countsByYear W27959618302022 @default.
• W2795961830 countsByYear W27959618302023 @default.
• W2795961830 crossrefType "journal-article" @default.
• W2795961830 hasAuthorship W2795961830A5002275174 @default.
• W2795961830 hasAuthorship W2795961830A5014881388 @default.
• W2795961830 hasAuthorship W2795961830A5024496950 @default.
• W2795961830 hasAuthorship W2795961830A5028233802 @default.
• W2795961830 hasAuthorship W2795961830A5043098809 @default.
• W2795961830 hasAuthorship W2795961830A5054534903 @default.
• W2795961830 hasAuthorship W2795961830A5066655787 @default.
• W2795961830 hasAuthorship W2795961830A5089925493 @default.
• W2795961830 hasBestOaLocation W27959618301 @default.
• W2795961830 hasConcept C104317684 @default.
• W2795961830 hasConcept C119857082 @default.
• W2795961830 hasConcept C120863210 @default.
• W2795961830 hasConcept C126322002 @default.
• W2795961830 hasConcept C144024400 @default.
• W2795961830 hasConcept C147583825 @default.
• W2795961830 hasConcept C149923435 @default.
• W2795961830 hasConcept C150194340 @default.
• W2795961830 hasConcept C190727270 @default.
• W2795961830 hasConcept C2775921022 @default.
• W2795961830 hasConcept C2777433710 @default.
• W2795961830 hasConcept C41008148 @default.
• W2795961830 hasConcept C42407357 @default.
• W2795961830 hasConcept C48921125 @default.
• W2795961830 hasConcept C54355233 @default.
• W2795961830 hasConcept C71924100 @default.
• W2795961830 hasConcept C86803240 @default.
• W2795961830 hasConceptScore W2795961830C104317684 @default.
• W2795961830 hasConceptScore W2795961830C119857082 @default.
• W2795961830 hasConceptScore W2795961830C120863210 @default.
• W2795961830 hasConceptScore W2795961830C126322002 @default.
• W2795961830 hasConceptScore W2795961830C144024400 @default.
• W2795961830 hasConceptScore W2795961830C147583825 @default.
• W2795961830 hasConceptScore W2795961830C149923435 @default.

• next