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- W2795976645 abstract "Abstract Commitment to a new cell cycle is controlled by a number of cellular signals. Mitogen-Activated Protein Kinase pathways, which transduce multiple extracellular cues, have been shown to be interconnected with the cell cycle. Using budding yeast as a model system, we have quantified in hundreds of live single cells the interplay between the MAPK regulating the mating response and the Cyclin-Dependent Kinase controlling cell cycle progression. Different patterns of MAPK activity dynamics could be identified by clustering cells based on their CDK activity, denoting the tight relationship between these two cellular signals. In mating mixtures, we have verified that the interplay between CDK and MAPK activities allows cells to select their fate, preventing them from being blocked in an undesirable cellular program." @default.
- W2795976645 created "2018-04-13" @default.
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- W2795976645 date "2018-03-02" @default.
- W2795976645 modified "2023-09-26" @default.
- W2795976645 title "Cross-regulation between CDK and MAPK control cellular fate" @default.
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- W2795976645 doi "https://doi.org/10.1101/274787" @default.
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