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• W2795978314 abstract "Eight novel acetophenone mono- and bis-C-glucosides were obtained by whole cells harboring an engineered C-glycosyltransferase. Optimization of the fed-bath process improved the yield of 4a to 0.97 mg/mL with 95% conversion rate, which is 2.9-fold higher than that of the single-bath. Four mono-C-glucosides (1a–4a) exhibited potent SGLT2 inhibitory activities with IC50 values at 10−6 M. These findings provide a cost-effective and practical synthetic strategy to produce structurally diverse and novel bioactive C-glucosides for drug discovery." @default.
• W2795978314 created "2018-04-13" @default.
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• W2795978314 date "2018-05-01" @default.
• W2795978314 modified "2023-10-18" @default.
• W2795978314 title "Production of acetophenone C-glucosides using an engineered C-glycosyltransferase in Escherichia coli" @default.
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• W2795978314 doi "https://doi.org/10.1016/j.tetlet.2018.04.006" @default.
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