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- W2795992404 endingPage "441" @default.
- W2795992404 startingPage "431" @default.
- W2795992404 abstract "Colorectal cancer (CRC) is one of the most common malignancies in the world. Easier recurrence and metastasis is the main cause of mortality in CRC patients, and the markers applied for diagnosis and treatment of CRC is still urgently needed to early diagnose and evaluate therapeutic effect. Long noncoding RNA (lncRNA) is a class of noncoding RNA that the length is more than 200 nucleotides. With the development of sequencing technique about transcriptome, increasing lncRNAs are focused on their function and mechanism related to the nosogenesis and pathology of CRC. Recent studies report that lncRNAs acted as crucial role in CRC and could be as biomarker for CRC diagnosis and treatment. In this review, we display the regulation of lncRNA by interacting with DNA, RNA and protein and highlight the double role of lncRNAs as oncogene or anti-tumor gene involved in Wnt signaling pathway, p53 signaling pathway or others to be an regulator in CRC development. Lastly, we discuss some new finding of lncRNAs, especially lncRNA in exosome, which could be as potential markers for diagnosis and treatment of CRC in future." @default.
- W2795992404 created "2018-04-13" @default.
- W2795992404 creator A5004273251 @default.
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- W2795992404 creator A5065101220 @default.
- W2795992404 creator A5065709603 @default.
- W2795992404 creator A5081424082 @default.
- W2795992404 creator A5084424777 @default.
- W2795992404 date "2018-01-01" @default.
- W2795992404 modified "2023-09-23" @default.
- W2795992404 title "The Biological Effect and Clinical Application of Long Noncoding RNAs in Colorectal Cancer" @default.
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- W2795992404 doi "https://doi.org/10.1159/000488610" @default.