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• W2796001641 abstract "One of the major contributions to protective immunity to influenza viruses that is provided by virus-specific CD4 T cells is delivery of effector function to the infected lung. However, there is little known about the selection and breadth of viral epitope-specific CD4 T cells that home to the lung after their initial priming. In this study, using a mouse model of influenza A infection and an unbiased method of epitope identification, the viral epitope-specific CD4 T cells elicited after infection were identified and quantified. We found that a very diverse specificity of CD4 T cells is primed by infection, including epitopes from hemagglutinin, neuraminidase, matrix protein, nucleoprotein and non-structural protein-1. Using peptide-specific cytokine EliSpots, the diversity and immunodominance hierarchies established in the lung-draining lymph node was compared with specificities of CD4 T cells that home to the lung. Our studies revealed that CD4 T cells of all epitope specificities identified in peripheral lymphoid tissue home back to the lung and that most of these lung-homing cells are localized within the tissue rather than the pulmonary vasculature. There is a striking shift of CD4 T cell functionality that enriches for IFN-γ production as cells are primed in the lymph node, enter the lung vasculature and finally establish residency in the tissue, but with no apparent shifts in their functional avidity. We conclude that CD4 T cells of broad viral epitope specificity are recruited into the lung after influenza infection, where they then have the opportunity to encounter infected or antigen-bearing antigen presenting cells." @default.
• W2796001641 created "2018-04-13" @default.
• W2796001641 creator A5010803502 @default.
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• W2796001641 date "2018-04-06" @default.
• W2796001641 modified "2023-09-23" @default.
• W2796001641 title "Diverse Epitope Specificity, Immunodominance Hierarchy, and Functional Avidity of Effector CD4 T Cells Established During Priming Is Maintained in Lung After Influenza A Virus Infection" @default.
• W2796001641 cites W1506618532 @default.
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• W2796001641 cites W1611988858 @default.
• W2796001641 cites W1655068946 @default.
• W2796001641 cites W1907177142 @default.
• W2796001641 cites W1931478385 @default.
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• W2796001641 cites W1973139453 @default.
• W2796001641 cites W1974540435 @default.
• W2796001641 cites W1985859196 @default.
• W2796001641 cites W1986941858 @default.
• W2796001641 cites W1993547722 @default.
• W2796001641 cites W2009253992 @default.
• W2796001641 cites W2011270644 @default.
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• W2796001641 cites W2016837553 @default.
• W2796001641 cites W2022557484 @default.
• W2796001641 cites W2023251537 @default.
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• W2796001641 cites W2124325544 @default.
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• W2796001641 doi "https://doi.org/10.3389/fimmu.2018.00655" @default.
• W2796001641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5897437" @default.
• W2796001641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29681900" @default.
• W2796001641 hasPublicationYear "2018" @default.
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