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- W2796006469 abstract "Mainstay therapeutics are ineffective in some people with asthma, suggesting a need for additional agents. In the current study, we used vagal ganglia transcriptome profiling and connectivity mapping to identify compounds beneficial for alleviating airway hyperreactivity (AHR). As a comparison, we also used previously published transcriptome data from sensitized mouse lungs and human asthmatic endobronchial biopsies. All transcriptomes revealed agents beneficial for mitigating AHR; however, only the vagal ganglia transcriptome identified agents used clinically to treat asthma (flunisolide, isoetarine). We also tested one compound identified by vagal ganglia transcriptome profiling that had not previously been linked to asthma and found that it had bronchodilator effects in both mouse and pig airways. These data suggest that transcriptome profiling of the vagal ganglia might be a novel strategy to identify potential asthma therapeutics." @default.
- W2796006469 created "2018-04-13" @default.
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- W2796006469 date "2018-08-01" @default.
- W2796006469 modified "2023-10-12" @default.
- W2796006469 title "The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity" @default.
- W2796006469 cites W1513929611 @default.
- W2796006469 cites W1546862061 @default.
- W2796006469 cites W1612782124 @default.
- W2796006469 cites W1652490597 @default.
- W2796006469 cites W1785101364 @default.
- W2796006469 cites W1805119337 @default.
- W2796006469 cites W1965228124 @default.
- W2796006469 cites W1967742696 @default.
- W2796006469 cites W1973048934 @default.
- W2796006469 cites W1973379008 @default.
- W2796006469 cites W1974876516 @default.
- W2796006469 cites W1979169522 @default.
- W2796006469 cites W1980290585 @default.
- W2796006469 cites W1980509598 @default.
- W2796006469 cites W1980559892 @default.
- W2796006469 cites W1984062113 @default.
- W2796006469 cites W1986895579 @default.
- W2796006469 cites W198974309 @default.
- W2796006469 cites W1992767102 @default.
- W2796006469 cites W1993079872 @default.
- W2796006469 cites W1995590059 @default.
- W2796006469 cites W2002987251 @default.
- W2796006469 cites W2013223817 @default.
- W2796006469 cites W2015064885 @default.
- W2796006469 cites W2016936023 @default.
- W2796006469 cites W201944994 @default.
- W2796006469 cites W2022106874 @default.
- W2796006469 cites W2023304501 @default.
- W2796006469 cites W2029491726 @default.
- W2796006469 cites W2031870085 @default.
- W2796006469 cites W2032114162 @default.
- W2796006469 cites W2032313194 @default.
- W2796006469 cites W2033030260 @default.
- W2796006469 cites W2033757830 @default.
- W2796006469 cites W204371507 @default.
- W2796006469 cites W2046585071 @default.
- W2796006469 cites W2047324209 @default.
- W2796006469 cites W2052916446 @default.
- W2796006469 cites W2058217612 @default.
- W2796006469 cites W2058645068 @default.
- W2796006469 cites W2061603090 @default.
- W2796006469 cites W2061768754 @default.
- W2796006469 cites W2065116414 @default.
- W2796006469 cites W2069295116 @default.
- W2796006469 cites W2069595758 @default.
- W2796006469 cites W2069681814 @default.
- W2796006469 cites W2070973756 @default.
- W2796006469 cites W2071602597 @default.
- W2796006469 cites W2077641788 @default.
- W2796006469 cites W2078508636 @default.
- W2796006469 cites W2080104628 @default.
- W2796006469 cites W2081557259 @default.
- W2796006469 cites W2084319738 @default.
- W2796006469 cites W2084942072 @default.
- W2796006469 cites W2085013364 @default.
- W2796006469 cites W2085187096 @default.
- W2796006469 cites W2091030143 @default.
- W2796006469 cites W2093583272 @default.
- W2796006469 cites W2099582158 @default.
- W2796006469 cites W2099979972 @default.
- W2796006469 cites W2101026179 @default.
- W2796006469 cites W2101772040 @default.
- W2796006469 cites W2103839002 @default.
- W2796006469 cites W2105643869 @default.
- W2796006469 cites W2109644936 @default.
- W2796006469 cites W2113892738 @default.
- W2796006469 cites W2114183739 @default.
- W2796006469 cites W2114967319 @default.
- W2796006469 cites W2121604817 @default.
- W2796006469 cites W2123596413 @default.
- W2796006469 cites W2125222435 @default.
- W2796006469 cites W2134677714 @default.
- W2796006469 cites W2141730865 @default.
- W2796006469 cites W2151904457 @default.
- W2796006469 cites W2153866915 @default.
- W2796006469 cites W2160278631 @default.
- W2796006469 cites W2166745068 @default.
- W2796006469 cites W2175455493 @default.
- W2796006469 cites W2183118557 @default.
- W2796006469 cites W2204169677 @default.
- W2796006469 cites W2254958366 @default.
- W2796006469 cites W2325721183 @default.
- W2796006469 cites W2406196384 @default.