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- W2796014034 abstract "Abstract A fitness landscape is a map between the genotype and its reproductive success in a given environment. The topography of fitness landscapes largely governs adaptive dynamics, constraining evolutionary trajectories and the predictability of evolution. Theory suggests that this topography can be “deformed” by mutations that produce substantial changes to the environment. In spite of its importance, the deformability of fitness landscapes has not been systematically studied beyond abstract models, and little is known about its reach and consequences in empirical systems. Here we have systematically characterized the deformability of the genome-wide metabolic fitness landscape of the bacterium E. coli . Deformability is quantified by the non-commutativity of epistatic interactions, which we experimentally demonstrate in mutant strains on the path to an evolutionary innovation. Our analysis shows that the deformation of fitness landscapes by metabolic mutations rarely affects evolutionary trajectories in the short-range. However, mutations with large environmental effects leave these as a “legacy”, producing long-range landscape deformations in distant regions of the genotype space that affect the fitness of later descendants. Our methods and results provide the basis for an integration between adaptive and eco-evolutionary dynamics with complex genetics and genomics." @default.
- W2796014034 created "2018-04-13" @default.
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- W2796014034 date "2018-04-02" @default.
- W2796014034 modified "2023-09-24" @default.
- W2796014034 title "On the deformability of an empirical fitness landscape by microbial evolution" @default.
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- W2796014034 doi "https://doi.org/10.1101/293407" @default.
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