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- W2796151385 abstract "Thiopurines (azathioprine and mercaptopurine) are widely used in patients with inflammatory bowel disease. In this paper, we review the main indications for their use, as well as practical aspects on efficacy, safety and method of administration. They are mainly used to maintain remission in steroid-dependent disease or with ciclosporin to control a severe ulcerative colitis flare-up, as well as to prevent postoperative Crohn's disease recurrence, and also in combination therapy with biologics. About 30-40% of patients will not respond to treatment and 10-20% will not tolerate it due to adverse effects. Before they are prescribed, immunisation status against certain infections should be checked. Determination of thiopurine methyltransferase activity (TPMT) is not mandatory but it increases initial safety. The appropriate dose is 2.5mg/kg/day for azathioprine and 1.5mg/kg/day for mercaptopurine. Some adverse effects are idiosyncratic (digestive intolerance, pancreatitis, fever, arthromyalgia, rash and some forms of hepatotoxicity). Others are dose-dependent (myelotoxicity and other types of hepatotoxicity), and their surveillance should never be interrupted during treatment. If therapy fails or adverse effects develop, management can include switching from one thiopurine to the other, reducing the dose, combining low doses of azathioprine with allopurinol and assessing metabolites, before their use is ruled out. Non-melanoma skin cancer, lymphomas and urinary tract tumours have been linked to thiopurine therapy. Thiopurine use is safe during conception, pregnancy and breastfeeding." @default.
- W2796151385 created "2018-04-13" @default.
- W2796151385 creator A5011716973 @default.
- W2796151385 creator A5014254734 @default.
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- W2796151385 date "2018-03-01" @default.
- W2796151385 modified "2023-10-08" @default.
- W2796151385 title "Recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on the use of thiopurines in inflammatory bowel disease" @default.
- W2796151385 cites W1410441244 @default.
- W2796151385 cites W1499566049 @default.
- W2796151385 cites W1511937926 @default.
- W2796151385 cites W1534517380 @default.
- W2796151385 cites W1539062823 @default.
- W2796151385 cites W1553784037 @default.
- W2796151385 cites W1561556445 @default.
- W2796151385 cites W1612648896 @default.
- W2796151385 cites W1966442237 @default.
- W2796151385 cites W1966893199 @default.
- W2796151385 cites W1969154585 @default.
- W2796151385 cites W1969412874 @default.
- W2796151385 cites W1970611979 @default.
- W2796151385 cites W1973289259 @default.
- W2796151385 cites W1973930882 @default.
- W2796151385 cites W1974242080 @default.
- W2796151385 cites W1976891063 @default.
- W2796151385 cites W1977903334 @default.
- W2796151385 cites W1978683701 @default.
- W2796151385 cites W1981272396 @default.
- W2796151385 cites W1983306049 @default.
- W2796151385 cites W1983770110 @default.
- W2796151385 cites W1984641899 @default.
- W2796151385 cites W1987941783 @default.
- W2796151385 cites W1988567794 @default.
- W2796151385 cites W1989216846 @default.
- W2796151385 cites W1989471372 @default.
- W2796151385 cites W1995661596 @default.
- W2796151385 cites W1996409190 @default.
- W2796151385 cites W1997402233 @default.
- W2796151385 cites W2000368489 @default.
- W2796151385 cites W2001136502 @default.
- W2796151385 cites W2002738619 @default.
- W2796151385 cites W2002964844 @default.
- W2796151385 cites W2005855936 @default.
- W2796151385 cites W2006600005 @default.
- W2796151385 cites W2007180159 @default.
- W2796151385 cites W2008687669 @default.
- W2796151385 cites W2012893442 @default.
- W2796151385 cites W2014523285 @default.
- W2796151385 cites W2016837646 @default.
- W2796151385 cites W2017996943 @default.
- W2796151385 cites W2022776197 @default.
- W2796151385 cites W2024293518 @default.
- W2796151385 cites W2025388964 @default.
- W2796151385 cites W2025988467 @default.
- W2796151385 cites W2026427400 @default.
- W2796151385 cites W2028608699 @default.
- W2796151385 cites W2028887550 @default.
- W2796151385 cites W2035421978 @default.
- W2796151385 cites W2035746880 @default.
- W2796151385 cites W2036563054 @default.
- W2796151385 cites W2039401871 @default.
- W2796151385 cites W2041686072 @default.
- W2796151385 cites W2042229410 @default.
- W2796151385 cites W2051116897 @default.
- W2796151385 cites W2051544696 @default.
- W2796151385 cites W2051905113 @default.
- W2796151385 cites W2054672031 @default.
- W2796151385 cites W2056917411 @default.
- W2796151385 cites W2057400141 @default.
- W2796151385 cites W2058773258 @default.
- W2796151385 cites W2059292323 @default.
- W2796151385 cites W2060513030 @default.
- W2796151385 cites W2062369130 @default.
- W2796151385 cites W2064485014 @default.
- W2796151385 cites W2065350405 @default.
- W2796151385 cites W2065582042 @default.
- W2796151385 cites W2068230421 @default.
- W2796151385 cites W2068255175 @default.
- W2796151385 cites W2071030284 @default.
- W2796151385 cites W2072179061 @default.
- W2796151385 cites W2075888728 @default.
- W2796151385 cites W2076449779 @default.
- W2796151385 cites W2077346034 @default.
- W2796151385 cites W2077677554 @default.
- W2796151385 cites W2080428749 @default.
- W2796151385 cites W2081689742 @default.
- W2796151385 cites W2082158443 @default.
- W2796151385 cites W2083146436 @default.
- W2796151385 cites W2085015858 @default.
- W2796151385 cites W2088315857 @default.
- W2796151385 cites W2089240629 @default.
- W2796151385 cites W2090549398 @default.