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• W2796154906 abstract "You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy VI1 Apr 2018PD42-02 LOWERING POSITIVE MARGIN RATES AT RADICAL PROSTATECTOMY BY COLOR CODING OF BIOPSY SPECIMENS TO PERMIT INDIVIDUALIZED PRESERVATION OF THE NEUROVASCULAR BUNDLES: IS IT FEASIBLE? A PILOT INVESTIGATION. Wei Phin Tan, Patrick Whelan, Ritu Ghai, Shahid Ekbal, and Leslie Deane Wei Phin TanWei Phin Tan More articles by this author , Patrick WhelanPatrick Whelan More articles by this author , Ritu GhaiRitu Ghai More articles by this author , Shahid EkbalShahid Ekbal More articles by this author , and Leslie DeaneLeslie Deane More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.1955AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The ability of mpMRI to distinguish extracapsular extension from organ-confined disease when a lesion in is contact with the capsule remains poor and has very limited sensitivity. We aim to evaluate whether color-coding of core biopsy specimens aid in preservation of the neurovascular bundles on radical prostatectomy, from an oncological perspective. METHODS MRI guided transrectal ultrasound and biopsy of the prostate was performed in 51 consecutive patients suspected of being high risk for harboring prostate cancer. Core specimens were labeled with blue dye at the deep aspect and red dye at the superficial peripheral aspect of the core. The distance from the tumor to the end of the dyed specimen was measured to determine if there was an area of normal tissue between the prostate capsule and tumor (figure 1). RESULTS Of the 51 patients undergoing prostate biopsy, 30 (58.8 %) were found to have cancer of the prostate. This was Grade Group 1 in 13.7 %, 2 in 25.5 %, 3 in 7.8 %, 4 in 7.8 % and 5 in 3.9 % of the cohort. A total of 461 cores were analyzed in the cohort, of which 122 showed cancer. 4 patients opted to undergo robotic assisted laparoscopic radical prostatectomy. No patients had a positive surgical margin (PSM) or extra prostatic extension (EPE) on radical prostatectomy if there was a margin of normal prostatic tissue seen between the dye and the tumor on prostate biopsy. Color coding the specimen does not alter the cellular architecture, nor does it affect the integrity of DNA/RNA material, thus having no potential for impacting genomic assessment of the tissue for further clinical risk analysis and stratification. CONCLUSIONS Color-coding of prostate biopsy core specimens assists in tailoring the approach to preservation of the neurovascular bundles without compromising early oncological efficacy. Further study is required to determine whether this simple modification of the prostate biopsy protocol is valuable in larger groups of patients. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e814 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Wei Phin Tan More articles by this author Patrick Whelan More articles by this author Ritu Ghai More articles by this author Shahid Ekbal More articles by this author Leslie Deane More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2796154906 title "PD42-02 LOWERING POSITIVE MARGIN RATES AT RADICAL PROSTATECTOMY BY COLOR CODING OF BIOPSY SPECIMENS TO PERMIT INDIVIDUALIZED PRESERVATION OF THE NEUROVASCULAR BUNDLES: IS IT FEASIBLE? A PILOT INVESTIGATION." @default.
• W2796154906 doi "https://doi.org/10.1016/j.juro.2018.02.1955" @default.
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