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- W2796169150 endingPage "92" @default.
- W2796169150 startingPage "77" @default.
- W2796169150 abstract "Retinal ganglion cell (RGC) degeneration causes vision loss in patients with glaucoma, and this has been generally considered to be irreversible due to RGC death. We question this assertion and summarise accumulating evidence that points to visual function improving in glaucoma patients with treatment, particularly in the early stages of disease. We propose that prior to death, RGCs enter periods of dysfunction but can recover with relief of RGC stress. We first summarise the clinical evidence for vision improvement in glaucoma and then detail our experimental work that points to the underlying processes that underpin clinical improvement. We show that functional recovery can occur following a prolonged course of RGC dysfunction and demonstrate how the capacity for recovery can be modified. Detecting RGC dysfunction and augmenting recovery of such ‘comatosed’ RGCs holds clinical potential to improve early detection of glaucoma and improve visual function." @default.
- W2796169150 created "2018-04-13" @default.
- W2796169150 creator A5006559108 @default.
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- W2796169150 creator A5070047765 @default.
- W2796169150 creator A5087967667 @default.
- W2796169150 date "2018-07-01" @default.
- W2796169150 modified "2023-10-04" @default.
- W2796169150 title "The coma in glaucoma: Retinal ganglion cell dysfunction and recovery" @default.
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