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• W2796191765 abstract "Summary Pathogenic bacteria taken up into the macrophage phagosome are the target of many anti-microbial effector molecules. Although mitochondria-derived antimicrobial effectors such as reactive oxygen species (mROS) are reported to aid in bacterial killing, it is unclear how these effectors reach bacteria within the phagosomal lumen. To examine the crosstalk between mitochondria and phagosomes, we monitored the production and the spatial localization of mROS during methicillin-resistant Staphylococcus aureus (MRSA) infection. We showed here mROS, specifically hydrogen peroxide (mH 2 O 2 ) can be delivered into phagosomes via infection-induced mitochondria-derived vesicles, which are generated in a Parkin-dependent manner. Accumulation of mH 2 O 2 in phagosomes required TLR signaling and the mitochondrial superoxide dismutase, Sod2, which converts superoxide into mH 2 O 2 . These data highlight a novel mechanism by which the mitochondrial redox capacity enhances macrophage antimicrobial function by delivering mitochondria-derived effector molecules into bacteria-containing phagosomes." @default.
• W2796191765 created "2018-04-13" @default.
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• W2796191765 date "2018-03-05" @default.
• W2796191765 modified "2023-09-26" @default.
• W2796191765 title "Mitochondria-derived vesicles deliver antimicrobial payload to control phagosomal bacteria" @default.
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• W2796191765 doi "https://doi.org/10.1101/277004" @default.
• W2796191765 hasPublicationYear "2018" @default.
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