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- W2796220714 endingPage "1336" @default.
- W2796220714 startingPage "1311" @default.
- W2796220714 abstract "Abstract This FlyBook chapter summarizes the history and the current state of our understanding of the Wingless signaling pathway. Wingless, the fly homolog of the mammalian Wnt oncoproteins, plays a central role in pattern generation during development. Much of what we know about the pathway was learned from genetic and molecular experiments in Drosophila melanogaster, and the core pathway works the same way in vertebrates. Like most growth factor pathways, extracellular Wingless/Wnt binds to a cell surface complex to transduce signal across the plasma membrane, triggering a series of intracellular events that lead to transcriptional changes in the nucleus. Unlike most growth factor pathways, the intracellular events regulate the protein stability of a key effector molecule, in this case Armadillo/β-catenin. A number of mysteries remain about how the “destruction complex” destabilizes β-catenin and how this process is inactivated by the ligand-bound receptor complex, so this review of the field can only serve as a snapshot of the work in progress." @default.
- W2796220714 created "2018-04-13" @default.
- W2796220714 creator A5078990849 @default.
- W2796220714 date "2018-04-01" @default.
- W2796220714 modified "2023-10-01" @default.
- W2796220714 title "Wingless Signaling: A Genetic Journey from Morphogenesis to Metastasis" @default.
- W2796220714 cites W117473054 @default.
- W2796220714 cites W1433152810 @default.
- W2796220714 cites W1485377536 @default.
- W2796220714 cites W1504655784 @default.
- W2796220714 cites W1511545125 @default.
- W2796220714 cites W1534431990 @default.
- W2796220714 cites W1537657975 @default.
- W2796220714 cites W15778579 @default.
- W2796220714 cites W1580962701 @default.
- W2796220714 cites W1582072542 @default.
- W2796220714 cites W1596316114 @default.
- W2796220714 cites W1628811763 @default.
- W2796220714 cites W1635607892 @default.
- W2796220714 cites W1648692159 @default.
- W2796220714 cites W1649982107 @default.
- W2796220714 cites W1723090406 @default.
- W2796220714 cites W1819149160 @default.
- W2796220714 cites W1819307633 @default.
- W2796220714 cites W1833245698 @default.
- W2796220714 cites W1844005993 @default.
- W2796220714 cites W1849230910 @default.
- W2796220714 cites W1854224404 @default.
- W2796220714 cites W1871724379 @default.
- W2796220714 cites W1880648489 @default.
- W2796220714 cites W1889767892 @default.
- W2796220714 cites W1901013657 @default.
- W2796220714 cites W1906082248 @default.
- W2796220714 cites W1911201077 @default.
- W2796220714 cites W1912766252 @default.
- W2796220714 cites W1923089477 @default.
- W2796220714 cites W1927705215 @default.
- W2796220714 cites W1943554998 @default.
- W2796220714 cites W1951102280 @default.
- W2796220714 cites W1956572439 @default.
- W2796220714 cites W1961449438 @default.
- W2796220714 cites W1964223904 @default.
- W2796220714 cites W1964837364 @default.
- W2796220714 cites W1968203653 @default.
- W2796220714 cites W1968598003 @default.
- W2796220714 cites W1968689612 @default.
- W2796220714 cites W1969378153 @default.
- W2796220714 cites W1970948460 @default.
- W2796220714 cites W1971388047 @default.
- W2796220714 cites W1971525809 @default.
- W2796220714 cites W1973648921 @default.
- W2796220714 cites W1974094726 @default.
- W2796220714 cites W1974482866 @default.
- W2796220714 cites W1975420952 @default.
- W2796220714 cites W1975803734 @default.
- W2796220714 cites W1976247593 @default.
- W2796220714 cites W1977025966 @default.
- W2796220714 cites W1977462853 @default.
- W2796220714 cites W1978725087 @default.
- W2796220714 cites W1978789471 @default.
- W2796220714 cites W1979040385 @default.
- W2796220714 cites W1979825058 @default.
- W2796220714 cites W1980955976 @default.
- W2796220714 cites W1982244603 @default.
- W2796220714 cites W1983203736 @default.
- W2796220714 cites W1984981442 @default.
- W2796220714 cites W1988532857 @default.
- W2796220714 cites W1989117766 @default.
- W2796220714 cites W1989126510 @default.
- W2796220714 cites W1989215255 @default.
- W2796220714 cites W1990586804 @default.
- W2796220714 cites W1991461487 @default.
- W2796220714 cites W1991738093 @default.
- W2796220714 cites W1991771956 @default.
- W2796220714 cites W1994323820 @default.
- W2796220714 cites W1994528729 @default.
- W2796220714 cites W1994979890 @default.
- W2796220714 cites W1997299451 @default.
- W2796220714 cites W1997368786 @default.
- W2796220714 cites W1997467265 @default.
- W2796220714 cites W1997732032 @default.
- W2796220714 cites W1999408122 @default.
- W2796220714 cites W1999430771 @default.
- W2796220714 cites W2000015384 @default.
- W2796220714 cites W2000572318 @default.
- W2796220714 cites W2000978157 @default.
- W2796220714 cites W2003362984 @default.
- W2796220714 cites W2003778163 @default.
- W2796220714 cites W2005865365 @default.
- W2796220714 cites W2006272730 @default.
- W2796220714 cites W2008448536 @default.
- W2796220714 cites W2008815241 @default.
- W2796220714 cites W2010044764 @default.
- W2796220714 cites W2010155516 @default.
- W2796220714 cites W2012418269 @default.
- W2796220714 cites W2012674191 @default.
- W2796220714 cites W2012932067 @default.
- W2796220714 cites W2013204587 @default.