FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2796260013> ?p ?o ?g. }

• W2796260013 abstract "Abstract Cancer is a complex and heterogeneous disease. It is crucial to identify the key driver genes and their role in cancer mechanisms with attention to different cancer stages, types or subtypes. Cancer driver genes are elusive and their discovery is complicated by the fact that the same gene can play a diverse role in different contexts. Key biological processes, such as cell proliferation and cell death, have been linked to cancer progression. Thus, in principle, they can be exploited to classify the cancer genes and unveil their role. Here, we present a new method, Moonlight, that exploit expression data to classify cancer genes. Moonlight relies on the integration of functional enrichment analysis, gene regulatory networks and upstream regulator analysis from expression data to score the importance of biological cancer-related processes taking into account either the inter- or intra-tumor heterogeneity. We then employed these scores to predict if each gene acts as a tumor suppressor gene (TSG) or as an oncogene (OCG). Our methodology also allow to predict genes with dual role, i.e. the moonlight genes (TSG in one cancer type or stage and OCG in another), as well as to elucidate the underlying biological processes. Availability: https://bioconductor.org/packages/MoonlightR & https://github.com/ibsquare/MoonlightR/" @default.
• W2796260013 created "2018-04-13" @default.
• W2796260013 creator A5022031677 @default.
• W2796260013 creator A5037265705 @default.
• W2796260013 creator A5040229926 @default.
• W2796260013 creator A5042706674 @default.
• W2796260013 creator A5058483070 @default.
• W2796260013 creator A5059245033 @default.
• W2796260013 creator A5062067186 @default.
• W2796260013 creator A5072869049 @default.
• W2796260013 creator A5076515219 @default.
• W2796260013 creator A5077253721 @default.
• W2796260013 creator A5078471371 @default.
• W2796260013 creator A5079804568 @default.
• W2796260013 creator A5089976447 @default.
• W2796260013 creator A5091051150 @default.
• W2796260013 date "2018-02-14" @default.
• W2796260013 modified "2023-10-16" @default.
• W2796260013 title "Moonlight: a tool for biological interpretation and driver genes discovery" @default.
• W2796260013 cites W1494567425 @default.
• W2796260013 cites W1908864745 @default.
• W2796260013 cites W1958860233 @default.
• W2796260013 cites W1976789167 @default.
• W2796260013 cites W1987908519 @default.
• W2796260013 cites W1989204866 @default.
• W2796260013 cites W2006832371 @default.
• W2796260013 cites W2009720434 @default.
• W2796260013 cites W2012724836 @default.
• W2796260013 cites W2025183726 @default.
• W2796260013 cites W2044433401 @default.
• W2796260013 cites W2067821218 @default.
• W2796260013 cites W2070831760 @default.
• W2796260013 cites W2084602409 @default.
• W2796260013 cites W2084941167 @default.
• W2796260013 cites W2101924219 @default.
• W2796260013 cites W2102140136 @default.
• W2796260013 cites W2123703855 @default.
• W2796260013 cites W2127281172 @default.
• W2796260013 cites W2130410032 @default.
• W2796260013 cites W2156631105 @default.
• W2796260013 cites W2168342464 @default.
• W2796260013 cites W2230320310 @default.
• W2796260013 cites W2557187647 @default.
• W2796260013 cites W2599586112 @default.
• W2796260013 doi "https://doi.org/10.1101/265322" @default.
• W2796260013 hasPublicationYear "2018" @default.
• W2796260013 type Work @default.
• W2796260013 sameAs 2796260013 @default.
• W2796260013 citedByCount "6" @default.
• W2796260013 countsByYear W27962600132018 @default.
• W2796260013 countsByYear W27962600132019 @default.
• W2796260013 crossrefType "posted-content" @default.
• W2796260013 hasAuthorship W2796260013A5022031677 @default.
• W2796260013 hasAuthorship W2796260013A5037265705 @default.
• W2796260013 hasAuthorship W2796260013A5040229926 @default.
• W2796260013 hasAuthorship W2796260013A5042706674 @default.
• W2796260013 hasAuthorship W2796260013A5058483070 @default.
• W2796260013 hasAuthorship W2796260013A5059245033 @default.
• W2796260013 hasAuthorship W2796260013A5062067186 @default.
• W2796260013 hasAuthorship W2796260013A5072869049 @default.
• W2796260013 hasAuthorship W2796260013A5076515219 @default.
• W2796260013 hasAuthorship W2796260013A5077253721 @default.
• W2796260013 hasAuthorship W2796260013A5078471371 @default.
• W2796260013 hasAuthorship W2796260013A5079804568 @default.
• W2796260013 hasAuthorship W2796260013A5089976447 @default.
• W2796260013 hasAuthorship W2796260013A5091051150 @default.
• W2796260013 hasBestOaLocation W27962600131 @default.
• W2796260013 hasConcept C104317684 @default.
• W2796260013 hasConcept C121608353 @default.
• W2796260013 hasConcept C150194340 @default.
• W2796260013 hasConcept C179185449 @default.
• W2796260013 hasConcept C18903297 @default.
• W2796260013 hasConcept C2777461020 @default.
• W2796260013 hasConcept C54355233 @default.
• W2796260013 hasConcept C67339327 @default.
• W2796260013 hasConcept C6929976 @default.
• W2796260013 hasConcept C70721500 @default.
• W2796260013 hasConcept C86803240 @default.
• W2796260013 hasConcept C96232424 @default.
• W2796260013 hasConceptScore W2796260013C104317684 @default.
• W2796260013 hasConceptScore W2796260013C121608353 @default.
• W2796260013 hasConceptScore W2796260013C150194340 @default.
• W2796260013 hasConceptScore W2796260013C179185449 @default.
• W2796260013 hasConceptScore W2796260013C18903297 @default.
• W2796260013 hasConceptScore W2796260013C2777461020 @default.
• W2796260013 hasConceptScore W2796260013C54355233 @default.
• W2796260013 hasConceptScore W2796260013C67339327 @default.
• W2796260013 hasConceptScore W2796260013C6929976 @default.
• W2796260013 hasConceptScore W2796260013C70721500 @default.
• W2796260013 hasConceptScore W2796260013C86803240 @default.
• W2796260013 hasConceptScore W2796260013C96232424 @default.
• W2796260013 hasLocation W27962600131 @default.
• W2796260013 hasOpenAccess W2796260013 @default.
• W2796260013 hasPrimaryLocation W27962600131 @default.
• W2796260013 hasRelatedWork W1495472541 @default.
• W2796260013 hasRelatedWork W1547016179 @default.
• W2796260013 hasRelatedWork W183875134 @default.
• W2796260013 hasRelatedWork W2034211922 @default.
• W2796260013 hasRelatedWork W2067558359 @default.
• W2796260013 hasRelatedWork W2121659696 @default.

• next