FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2796313641> ?p ?o ?g. }

• W2796313641 endingPage "11" @default.
• W2796313641 startingPage "1" @default.
• W2796313641 abstract "Chronic low-grade inflammation plays a major role in the development of insulin resistance. The potential role and underlying mechanism of vitamin C, an antioxidant and anti-inflammatory agent, was investigated in tumor necrosis factor-α (TNF-α)-induced insulin resistance. Gulonolactone oxidase knockout (Gulo-/-) mice genetically unable to synthesize vitamin C were used to induce insulin resistance by continuously pumping small doses of TNF-α for seven days, and human liver hepatocellular carcinoma cells (HepG2 cells) were used to induce insulin resistance by treatment with TNF-α. Vitamin C deficiency aggravated TNF-α-induced insulin resistance in Gulo-/- mice, resulting in worse glucose tolerance test (GTT) results, higher fasting plasma insulin level, and the inactivation of the protein kinase B (AKT)/glycogen synthase kinase-3β (GSK3β) pathway in the liver. Vitamin C deficiency also worsened liver lipid accumulation and inflammation in TNF-α-treated Gulo-/- mice. In HepG2 cells, vitamin C reversed the TNF-α-induced reduction of glucose uptake and glycogen synthesis, which were mediated by increasing GLUT2 levels and the activation of the insulin receptor substrate (IRS-1)/AKT/GSK3β pathway. Furthermore, vitamin C inhibited the TNF-α-induced activation of not only the mitogen-activated protein kinase (MAPKs), but also nuclear factor-kappa B (NF-κB) signaling. Taken together, vitamin C is essential for preventing and improving insulin resistance, and the supplementing with vitamin C may be an effective therapeutic intervention for metabolic disorders." @default.
• W2796313641 created "2018-04-13" @default.
• W2796313641 creator A5025610773 @default.
• W2796313641 creator A5035707420 @default.
• W2796313641 creator A5060314863 @default.
• W2796313641 creator A5090599562 @default.
• W2796313641 date "2018-06-01" @default.
• W2796313641 modified "2023-10-15" @default.
• W2796313641 title "Vitamin C deficiency aggravates tumor necrosis factor α-induced insulin resistance" @default.
• W2796313641 cites W1594170119 @default.
• W2796313641 cites W159669330 @default.
• W2796313641 cites W1912569913 @default.
• W2796313641 cites W1917865723 @default.
• W2796313641 cites W1980376777 @default.
• W2796313641 cites W1991401793 @default.
• W2796313641 cites W1992304595 @default.
• W2796313641 cites W1992316317 @default.
• W2796313641 cites W1993418845 @default.
• W2796313641 cites W1997409763 @default.
• W2796313641 cites W2001649002 @default.
• W2796313641 cites W2002006853 @default.
• W2796313641 cites W2011210301 @default.
• W2796313641 cites W2019319309 @default.
• W2796313641 cites W2033812665 @default.
• W2796313641 cites W2034340220 @default.
• W2796313641 cites W2038018821 @default.
• W2796313641 cites W2044055064 @default.
• W2796313641 cites W2044421981 @default.
• W2796313641 cites W2044635516 @default.
• W2796313641 cites W2045359670 @default.
• W2796313641 cites W2045926149 @default.
• W2796313641 cites W2046120487 @default.
• W2796313641 cites W2049704228 @default.
• W2796313641 cites W2049948494 @default.
• W2796313641 cites W2050477695 @default.
• W2796313641 cites W2052384271 @default.
• W2796313641 cites W2053290215 @default.
• W2796313641 cites W2065912402 @default.
• W2796313641 cites W2075596969 @default.
• W2796313641 cites W2076471542 @default.
• W2796313641 cites W2084561741 @default.
• W2796313641 cites W2100516350 @default.
• W2796313641 cites W2102817107 @default.
• W2796313641 cites W2120790798 @default.
• W2796313641 cites W2122873450 @default.
• W2796313641 cites W2125718576 @default.
• W2796313641 cites W2130850001 @default.
• W2796313641 cites W2136885098 @default.
• W2796313641 cites W2138044098 @default.
• W2796313641 cites W2138521238 @default.
• W2796313641 cites W2145670359 @default.
• W2796313641 cites W2162886425 @default.
• W2796313641 cites W2165601025 @default.
• W2796313641 cites W2194294353 @default.
• W2796313641 cites W2211634361 @default.
• W2796313641 cites W2238895548 @default.
• W2796313641 cites W2549132724 @default.
• W2796313641 cites W2554192146 @default.
• W2796313641 cites W2670442126 @default.
• W2796313641 cites W4238497443 @default.
• W2796313641 cites W4245857125 @default.
• W2796313641 doi "https://doi.org/10.1016/j.ejphar.2018.03.044" @default.
• W2796313641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29625084" @default.
• W2796313641 hasPublicationYear "2018" @default.
• W2796313641 type Work @default.
• W2796313641 sameAs 2796313641 @default.
• W2796313641 citedByCount "16" @default.
• W2796313641 countsByYear W27963136412020 @default.
• W2796313641 countsByYear W27963136412021 @default.
• W2796313641 countsByYear W27963136412022 @default.
• W2796313641 countsByYear W27963136412023 @default.
• W2796313641 crossrefType "journal-article" @default.
• W2796313641 hasAuthorship W2796313641A5025610773 @default.
• W2796313641 hasAuthorship W2796313641A5035707420 @default.
• W2796313641 hasAuthorship W2796313641A5060314863 @default.
• W2796313641 hasAuthorship W2796313641A5090599562 @default.
• W2796313641 hasConcept C112446052 @default.
• W2796313641 hasConcept C126322002 @default.
• W2796313641 hasConcept C134018914 @default.
• W2796313641 hasConcept C161573976 @default.
• W2796313641 hasConcept C17991360 @default.
• W2796313641 hasConcept C192118531 @default.
• W2796313641 hasConcept C2776914184 @default.
• W2796313641 hasConcept C2776940978 @default.
• W2796313641 hasConcept C2777391703 @default.
• W2796313641 hasConcept C2777901630 @default.
• W2796313641 hasConcept C2779306644 @default.
• W2796313641 hasConcept C55493867 @default.
• W2796313641 hasConcept C62478195 @default.
• W2796313641 hasConcept C71924100 @default.
• W2796313641 hasConcept C75217442 @default.
• W2796313641 hasConcept C86803240 @default.
• W2796313641 hasConceptScore W2796313641C112446052 @default.
• W2796313641 hasConceptScore W2796313641C126322002 @default.
• W2796313641 hasConceptScore W2796313641C134018914 @default.
• W2796313641 hasConceptScore W2796313641C161573976 @default.
• W2796313641 hasConceptScore W2796313641C17991360 @default.
• W2796313641 hasConceptScore W2796313641C192118531 @default.

• next