FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2796370959> ?p ?o ?g. }

• W2796370959 abstract "The tumour microenvironment is essential for cancer progress and metastasis. Integrin-β5 (ITGB5), a member of the integrin family, has been implicated to mediate the interactions of cells with the extracellular matrix (ECM) and promote tumorigenesis in several malignancies. However, the role of ITGB5 in hepatocellular carcinoma (HCC) is still unknown.The biological function of ITGB5 in HCC was investigated using migration, colony formation assays. The potential molecular mechanism of ITGB5 in regulating HCC tumorigenesis and β-catenin stabilization was investigated by western blotting, co-immunoprecipitation and ubiquitination assays. The expression level of ITGB5 mediated by miR-185 was confirmed by bioinformatic analysis, luciferase assay. The clinical significance of ITGB5 was based on human tissue microarray (TMA) analysis.Here, we found that the expression of ITGB5 is increased in HCC tissues. Elevated ITGB5 markedly facilitates HCC cell migration and tumorigenesis in vitro and in vivo. Further mechanistic studies revealed that ITGB5, as a partner of β-catenin, directly interacts with β-catenin and inhibits its degradation, thus leading to WNT/β-catenin activity. Subsequently, we also found that ITGB5 is a direct targeted gene of miR-185. The downregulation of miR-185 in HCC cells promotes an increase in ITGB5. An additional increase of ITGB5 is associated with β-catenin upregulation and a miR-185 decrease in HCC tissues.Our data reveal that the miR-185-ITGB5-β-catenin pathway plays an important role in HCC tumorigenesis, and ITGB5 may be a promising specific target for HCC therapy." @default.
• W2796370959 created "2018-04-13" @default.
• W2796370959 creator A5000452213 @default.
• W2796370959 creator A5018588746 @default.
• W2796370959 creator A5023646943 @default.
• W2796370959 creator A5036936468 @default.
• W2796370959 creator A5049924861 @default.
• W2796370959 creator A5052184277 @default.
• W2796370959 creator A5056578078 @default.
• W2796370959 creator A5086183522 @default.
• W2796370959 creator A5087084064 @default.
• W2796370959 date "2018-01-31" @default.
• W2796370959 modified "2023-10-16" @default.
• W2796370959 title "Integrin-β5, a miR-185-targeted gene, promotes hepatocellular carcinoma tumorigenesis by regulating β-catenin stability" @default.
• W2796370959 cites W1938226019 @default.
• W2796370959 cites W1941119820 @default.
• W2796370959 cites W1950118853 @default.
• W2796370959 cites W1974777081 @default.
• W2796370959 cites W1975622672 @default.
• W2796370959 cites W1987821958 @default.
• W2796370959 cites W1990856662 @default.
• W2796370959 cites W1996556203 @default.
• W2796370959 cites W2013781424 @default.
• W2796370959 cites W2014582683 @default.
• W2796370959 cites W2024934120 @default.
• W2796370959 cites W2058843732 @default.
• W2796370959 cites W2059665962 @default.
• W2796370959 cites W2065433187 @default.
• W2796370959 cites W2072554662 @default.
• W2796370959 cites W2081871084 @default.
• W2796370959 cites W2088037057 @default.
• W2796370959 cites W2100086304 @default.
• W2796370959 cites W2112566803 @default.
• W2796370959 cites W2129420347 @default.
• W2796370959 cites W2137052325 @default.
• W2796370959 cites W2139297732 @default.
• W2796370959 cites W2147000598 @default.
• W2796370959 cites W2148549145 @default.
• W2796370959 cites W2149736698 @default.
• W2796370959 cites W2163486683 @default.
• W2796370959 cites W2516788557 @default.
• W2796370959 cites W2591717879 @default.
• W2796370959 cites W2594703174 @default.
• W2796370959 cites W2610193187 @default.
• W2796370959 cites W2612151011 @default.
• W2796370959 cites W2748110529 @default.
• W2796370959 cites W2755175528 @default.
• W2796370959 cites W2758097371 @default.
• W2796370959 cites W2769590730 @default.
• W2796370959 cites W2917837889 @default.
• W2796370959 cites W4211105405 @default.
• W2796370959 cites W4251025034 @default.
• W2796370959 doi "https://doi.org/10.1186/s13046-018-0691-9" @default.
• W2796370959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5793391" @default.
• W2796370959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29386044" @default.
• W2796370959 hasPublicationYear "2018" @default.
• W2796370959 type Work @default.
• W2796370959 sameAs 2796370959 @default.
• W2796370959 citedByCount "40" @default.
• W2796370959 countsByYear W27963709592019 @default.
• W2796370959 countsByYear W27963709592020 @default.
• W2796370959 countsByYear W27963709592021 @default.
• W2796370959 countsByYear W27963709592022 @default.
• W2796370959 countsByYear W27963709592023 @default.
• W2796370959 crossrefType "journal-article" @default.
• W2796370959 hasAuthorship W2796370959A5000452213 @default.
• W2796370959 hasAuthorship W2796370959A5018588746 @default.
• W2796370959 hasAuthorship W2796370959A5023646943 @default.
• W2796370959 hasAuthorship W2796370959A5036936468 @default.
• W2796370959 hasAuthorship W2796370959A5049924861 @default.
• W2796370959 hasAuthorship W2796370959A5052184277 @default.
• W2796370959 hasAuthorship W2796370959A5056578078 @default.
• W2796370959 hasAuthorship W2796370959A5086183522 @default.
• W2796370959 hasAuthorship W2796370959A5087084064 @default.
• W2796370959 hasBestOaLocation W27963709591 @default.
• W2796370959 hasConcept C104317684 @default.
• W2796370959 hasConcept C121608353 @default.
• W2796370959 hasConcept C127561419 @default.
• W2796370959 hasConcept C137620995 @default.
• W2796370959 hasConcept C150194340 @default.
• W2796370959 hasConcept C185592680 @default.
• W2796370959 hasConcept C2778019345 @default.
• W2796370959 hasConcept C2779013556 @default.
• W2796370959 hasConcept C30145163 @default.
• W2796370959 hasConcept C502942594 @default.
• W2796370959 hasConcept C54355233 @default.
• W2796370959 hasConcept C555283112 @default.
• W2796370959 hasConcept C62478195 @default.
• W2796370959 hasConcept C8415881 @default.
• W2796370959 hasConcept C86803240 @default.
• W2796370959 hasConcept C95444343 @default.
• W2796370959 hasConceptScore W2796370959C104317684 @default.
• W2796370959 hasConceptScore W2796370959C121608353 @default.
• W2796370959 hasConceptScore W2796370959C127561419 @default.
• W2796370959 hasConceptScore W2796370959C137620995 @default.
• W2796370959 hasConceptScore W2796370959C150194340 @default.
• W2796370959 hasConceptScore W2796370959C185592680 @default.
• W2796370959 hasConceptScore W2796370959C2778019345 @default.
• W2796370959 hasConceptScore W2796370959C2779013556 @default.
• W2796370959 hasConceptScore W2796370959C30145163 @default.

• next