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- W2796394543 abstract "IL-5 is an important cytokine for priming and survival of mature eosinophils and for proliferation and maturation of their progenitors. Hence, IL-5(Rα) targeting will be increasingly used in diseases where eosinophils are the key immune effector cells such as eosinophilic asthma (EA), hypereosinophilic syndrome (HES), eosinophilic esophagitis (EE), and eosinophilic granulomatosis with polyangiitis (EGPA). Therefore, several neutralizing monoclonal antibodies directed against IL-5 (mepolizumab and reslizumab) and its receptor IL-5Rα (benralizumab) have found or will find their way to the clinic. While the clinical effect of these drugs has been extensively investigated and reviewed, the understanding of the underlying immunological and hematological mechanisms remains less clear. This review will discuss the translational outcomes of treatment with these monoclonal antibodies in humans to shed light on the mechanisms underlying the main immunological and hematological findings from these clinical trials in humans." @default.
- W2796394543 created "2018-04-13" @default.
- W2796394543 creator A5018087968 @default.
- W2796394543 creator A5031159404 @default.
- W2796394543 date "2018-10-01" @default.
- W2796394543 modified "2023-10-11" @default.
- W2796394543 title "Immunological and hematological effects of <scp>IL</scp> ‐5(Rα)‐targeted therapy: An overview" @default.
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- W2796394543 doi "https://doi.org/10.1111/all.13451" @default.
- W2796394543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6220846" @default.
- W2796394543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29611207" @default.