FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2796403904> ?p ?o ?g. }

• W2796403904 abstract "Members of the genus Streptomyces are Gram-positive bacteria that are used as important cell factories to produce secondary metabolites and secrete heterologous proteins. They possess some of the largest bacterial genomes and thus proteomes. Understanding their complex proteomes and metabolic regulation will improve any genetic engineering approach. Here, we performed a comprehensive annotation of the subcellular localization of the proteome of Streptomyces lividans TK24 and developed the Subcellular Topology of Polypeptides in Streptomyces database (SToPSdb) to make this information widely accessible. We first introduced a uniform, improved nomenclature that re-annotated the names of ~ 4000 proteins based on functional and structural information. Then protein localization was assigned de novo using prediction tools and edited by manual curation for 7494 proteins, including information for 183 proteins that resulted from a recent genome re-annotation and are not available in current databases. The S. lividans proteome was also linked with those of other model bacterial strains including Streptomyces coelicolor A3(2) and Escherichia coli K-12, based on protein homology, and can be accessed through an open web interface. Finally, experimental data derived from proteomics experiments have been incorporated and provide validation for protein existence or topology for 579 proteins. Proteomics also reveals proteins released from vesicles that bleb off the membrane. All export systems known in S. lividans are also presented and exported proteins assigned export routes, where known. SToPSdb provides an updated and comprehensive protein localization annotation resource for S. lividans and other streptomycetes. It forms the basis for future linking to databases containing experimental data of proteomics, genomics and metabolomics studies for this organism." @default.
• W2796403904 created "2018-04-13" @default.
• W2796403904 creator A5005291642 @default.
• W2796403904 creator A5008256216 @default.
• W2796403904 creator A5012037498 @default.
• W2796403904 creator A5017870709 @default.
• W2796403904 creator A5018584026 @default.
• W2796403904 creator A5026070090 @default.
• W2796403904 creator A5027056277 @default.
• W2796403904 creator A5030156142 @default.
• W2796403904 creator A5031589452 @default.
• W2796403904 creator A5034049086 @default.
• W2796403904 creator A5047302297 @default.
• W2796403904 creator A5049818957 @default.
• W2796403904 creator A5055357299 @default.
• W2796403904 creator A5058577851 @default.
• W2796403904 date "2018-03-15" @default.
• W2796403904 modified "2023-10-17" @default.
• W2796403904 title "Comprehensive subcellular topologies of polypeptides in Streptomyces" @default.
• W2796403904 cites W1525293196 @default.
• W2796403904 cites W1537641994 @default.
• W2796403904 cites W1559216832 @default.
• W2796403904 cites W1607784912 @default.
• W2796403904 cites W1634136431 @default.
• W2796403904 cites W1827213771 @default.
• W2796403904 cites W1900011911 @default.
• W2796403904 cites W1929520690 @default.
• W2796403904 cites W1964461001 @default.
• W2796403904 cites W1965154000 @default.
• W2796403904 cites W1966829555 @default.
• W2796403904 cites W1966994877 @default.
• W2796403904 cites W1971147414 @default.
• W2796403904 cites W1986118110 @default.
• W2796403904 cites W1987062982 @default.
• W2796403904 cites W1996609836 @default.
• W2796403904 cites W1998564815 @default.
• W2796403904 cites W2002572832 @default.
• W2796403904 cites W2004622806 @default.
• W2796403904 cites W2006437796 @default.
• W2796403904 cites W2011697808 @default.
• W2796403904 cites W2012081411 @default.
• W2796403904 cites W2012960603 @default.
• W2796403904 cites W2013339295 @default.
• W2796403904 cites W2014511091 @default.
• W2796403904 cites W2017500947 @default.
• W2796403904 cites W2027230322 @default.
• W2796403904 cites W2037830239 @default.
• W2796403904 cites W2044966886 @default.
• W2796403904 cites W2049312907 @default.
• W2796403904 cites W2055043387 @default.
• W2796403904 cites W2055872227 @default.
• W2796403904 cites W2056617280 @default.
• W2796403904 cites W2061385538 @default.
• W2796403904 cites W2064656060 @default.
• W2796403904 cites W2071640845 @default.
• W2796403904 cites W2074959362 @default.
• W2796403904 cites W2094201044 @default.
• W2796403904 cites W2096338485 @default.
• W2796403904 cites W2099673165 @default.
• W2796403904 cites W2103017472 @default.
• W2796403904 cites W2108611713 @default.
• W2796403904 cites W2108632205 @default.
• W2796403904 cites W2109131377 @default.
• W2796403904 cites W2114476287 @default.
• W2796403904 cites W2116205553 @default.
• W2796403904 cites W2122417006 @default.
• W2796403904 cites W2123803344 @default.
• W2796403904 cites W2124528240 @default.
• W2796403904 cites W2125377246 @default.
• W2796403904 cites W2130599662 @default.
• W2796403904 cites W2132192325 @default.
• W2796403904 cites W2134637395 @default.
• W2796403904 cites W2136861926 @default.
• W2796403904 cites W2138683225 @default.
• W2796403904 cites W2142304060 @default.
• W2796403904 cites W2152770371 @default.
• W2796403904 cites W2154171815 @default.
• W2796403904 cites W2164751980 @default.
• W2796403904 cites W2167127643 @default.
• W2796403904 cites W2175390955 @default.
• W2796403904 cites W2224056471 @default.
• W2796403904 cites W2335901076 @default.
• W2796403904 cites W2405978957 @default.
• W2796403904 cites W2413277622 @default.
• W2796403904 cites W2513557142 @default.
• W2796403904 cites W2552612734 @default.
• W2796403904 cites W2557496587 @default.
• W2796403904 cites W2559192784 @default.
• W2796403904 cites W2559835411 @default.
• W2796403904 cites W2566075162 @default.
• W2796403904 cites W2604808360 @default.
• W2796403904 cites W2607703196 @default.
• W2796403904 cites W2619962439 @default.
• W2796403904 cites W2780138950 @default.
• W2796403904 cites W2914041088 @default.
• W2796403904 doi "https://doi.org/10.1186/s12934-018-0892-0" @default.
• W2796403904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5853079" @default.
• W2796403904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29544487" @default.
• W2796403904 hasPublicationYear "2018" @default.
• W2796403904 type Work @default.

• next