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- W2796408038 abstract "ABSTRACT We study the effect of fluctuating environment in protein transport dynamics. In particular, we investigate the translocation of a structured biomolecule (protein) across a temporally modulated nano-pore. We allow the radius of the cylindrical pore to oscillate harmonically with certain frequency and amplitude about an average radius. The protein is imported inside the pore whose dynamics is influences by the fluctuating nature of the pore. We investigate the dynamic and thermodynamical properties of the translocation process by revealing the statistics of translocation time as a function of the pulling inward force acting along the axis of the pore, and the frequency of the time dependent radius of the channel. We also examine the distribution of translocation time in the intermediate frequency regime. We observe that the shaking mechanism of pore leads to accelerate the translocation process as compared to the static channel that has a radius equal to the mean radius of oscillating pore. Moreover, the translocation time shows a global maximum as a function of frequency of the oscillating radius, hence revealing a resonant activation phenomenon in the dynamics of protein translocation." @default.
- W2796408038 created "2018-04-13" @default.
- W2796408038 creator A5005220352 @default.
- W2796408038 date "2018-04-06" @default.
- W2796408038 modified "2023-10-14" @default.
- W2796408038 title "Translocation of structured biomolecule through a vibrating nanopore" @default.
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- W2796408038 doi "https://doi.org/10.1101/296780" @default.
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