Matches in SemOpenAlex for { <https://semopenalex.org/work/W2796472971> ?p ?o ?g. }
- W2796472971 endingPage "144" @default.
- W2796472971 startingPage "134" @default.
- W2796472971 abstract "Cerebral ischemia is known to be a major cause of death and the later development of Alzheimer's disease and vascular dementia. However, ischemia induced cellular damage that initiates these diseases remain poorly understood. This is primarily due to lack of clinically relevant models that are highly reproducible. Here, we have optimised a murine model of global cerebral ischaemia with multiple markers to determine brain pathology, neurochemistry and correlated memory deficits in these animals. Cerebral ischaemia in mice was induced by bilateral common carotid artery occlusion. Following reperfusion, the mice were either fixed with 4% paraformaldehyde or decapitated under anaesthesia. Brains were processed for Western blotting or immunohistochemistry for glial (GLT1) and vesicular (VGLUT1, VGLUT2) glutamate transporters and paired helical filament (PHF1) tau. The PHF1 tau is the main component of neurofibrillary tangle, which is the pathological hallmark of Alzheimer's disease and vascular dementia. The novel object recognition behavioural assay was used to investigate the functional cognitive consequences in these mice. The results show consistent and selective neuronal and glial cell changes in the hippocampus and the cortex together with significant reductions in GLT1 (***P < 0.001), VGLUT1 (**P < 0.01) and VGLUT2 (***P < 0.001) expressions in the hippocampus in occluded mice as compared to sham-operated animals. These changes are associated with increased PHF1 (***P < 0.0001) protein and a significant impairment of performance (*p < 0.0006, N = 6/group) in the novel object recognition test. This model represents a useful tool for investigating cellular, biochemical and molecular mechanisms of global cerebral ischaemia and may be an ideal preclinical model for vascular dementia." @default.
- W2796472971 created "2018-04-24" @default.
- W2796472971 creator A5007725435 @default.
- W2796472971 creator A5025155035 @default.
- W2796472971 creator A5043945100 @default.
- W2796472971 creator A5051029209 @default.
- W2796472971 creator A5063812019 @default.
- W2796472971 creator A5083577466 @default.
- W2796472971 date "2018-09-01" @default.
- W2796472971 modified "2023-10-17" @default.
- W2796472971 title "Tau pathology and neurochemical changes associated with memory dysfunction in an optimised murine model of global cerebral ischaemia - A potential model for vascular dementia?" @default.
- W2796472971 cites W1892897507 @default.
- W2796472971 cites W1900227502 @default.
- W2796472971 cites W1916330421 @default.
- W2796472971 cites W1969014948 @default.
- W2796472971 cites W1971967768 @default.
- W2796472971 cites W1973715876 @default.
- W2796472971 cites W1976901342 @default.
- W2796472971 cites W1983245960 @default.
- W2796472971 cites W1988594055 @default.
- W2796472971 cites W1998005675 @default.
- W2796472971 cites W2004476854 @default.
- W2796472971 cites W2004984841 @default.
- W2796472971 cites W2009784224 @default.
- W2796472971 cites W2013057989 @default.
- W2796472971 cites W2013481883 @default.
- W2796472971 cites W2029848289 @default.
- W2796472971 cites W2031486344 @default.
- W2796472971 cites W2037426713 @default.
- W2796472971 cites W2042902316 @default.
- W2796472971 cites W2047585900 @default.
- W2796472971 cites W204998232 @default.
- W2796472971 cites W2053276094 @default.
- W2796472971 cites W2060817651 @default.
- W2796472971 cites W2064679863 @default.
- W2796472971 cites W2065012668 @default.
- W2796472971 cites W2089397496 @default.
- W2796472971 cites W2100380391 @default.
- W2796472971 cites W2110705999 @default.
- W2796472971 cites W2115873263 @default.
- W2796472971 cites W2116447221 @default.
- W2796472971 cites W2118867129 @default.
- W2796472971 cites W2126033464 @default.
- W2796472971 cites W2130723719 @default.
- W2796472971 cites W2151594784 @default.
- W2796472971 cites W2155704304 @default.
- W2796472971 cites W2160935383 @default.
- W2796472971 cites W2166346463 @default.
- W2796472971 cites W2275229952 @default.
- W2796472971 cites W2588011604 @default.
- W2796472971 cites W4210979710 @default.
- W2796472971 cites W4241168058 @default.
- W2796472971 cites W822480655 @default.
- W2796472971 doi "https://doi.org/10.1016/j.neuint.2018.04.004" @default.
- W2796472971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29649504" @default.
- W2796472971 hasPublicationYear "2018" @default.
- W2796472971 type Work @default.
- W2796472971 sameAs 2796472971 @default.
- W2796472971 citedByCount "33" @default.
- W2796472971 countsByYear W27964729712018 @default.
- W2796472971 countsByYear W27964729712019 @default.
- W2796472971 countsByYear W27964729712020 @default.
- W2796472971 countsByYear W27964729712021 @default.
- W2796472971 countsByYear W27964729712022 @default.
- W2796472971 countsByYear W27964729712023 @default.
- W2796472971 crossrefType "journal-article" @default.
- W2796472971 hasAuthorship W2796472971A5007725435 @default.
- W2796472971 hasAuthorship W2796472971A5025155035 @default.
- W2796472971 hasAuthorship W2796472971A5043945100 @default.
- W2796472971 hasAuthorship W2796472971A5051029209 @default.
- W2796472971 hasAuthorship W2796472971A5063812019 @default.
- W2796472971 hasAuthorship W2796472971A5083577466 @default.
- W2796472971 hasBestOaLocation W27964729712 @default.
- W2796472971 hasConcept C126322002 @default.
- W2796472971 hasConcept C142724271 @default.
- W2796472971 hasConcept C148762608 @default.
- W2796472971 hasConcept C15744967 @default.
- W2796472971 hasConcept C16568411 @default.
- W2796472971 hasConcept C169760540 @default.
- W2796472971 hasConcept C170493617 @default.
- W2796472971 hasConcept C25876315 @default.
- W2796472971 hasConcept C2777952318 @default.
- W2796472971 hasConcept C2779134260 @default.
- W2796472971 hasConcept C2779483572 @default.
- W2796472971 hasConcept C2779721402 @default.
- W2796472971 hasConcept C2781161787 @default.
- W2796472971 hasConcept C39920043 @default.
- W2796472971 hasConcept C502032728 @default.
- W2796472971 hasConcept C541997718 @default.
- W2796472971 hasConcept C61174792 @default.
- W2796472971 hasConcept C68026918 @default.
- W2796472971 hasConcept C71924100 @default.
- W2796472971 hasConceptScore W2796472971C126322002 @default.
- W2796472971 hasConceptScore W2796472971C142724271 @default.
- W2796472971 hasConceptScore W2796472971C148762608 @default.
- W2796472971 hasConceptScore W2796472971C15744967 @default.
- W2796472971 hasConceptScore W2796472971C16568411 @default.
- W2796472971 hasConceptScore W2796472971C169760540 @default.