Matches in SemOpenAlex for { <https://semopenalex.org/work/W2796478082> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2796478082 abstract "The GABAergic system is the primary inhibitory regulator of the mesolimbic dopamine system, mediating both natural and drug-induced reward behaviours. The GABAB agonist, baclofen, has been postulated as a potential anti-addiction treatment. However, clinical studies have revealed conflicting results and both anti- and pro-rewarding effects of GABAB system activation have been reported. Thus, a deeper and more refined understanding of GABAB receptor pharmacology is needed. GABAB receptors are obligate heterodimers of GABAB(1) and GABAB(2) subunits and further GABAB(1) subunit isoforms are GABAB(1a) and GABAB(1b). While presynaptic GABAB receptors are likely to contain the GABAB(1a) isoform, postsynaptic GABAB receptors are composed of the GABAB(1b) isoform. Using mice lacking in GABAB(1a) (1a KO) and GABAB(1b) (1b KO) isoforms, we tested the hypothesis that the GABAB receptor isoforms differentially modulate psychomotor and reward behaviours of cocaine and morphine, alcohol intake and social behaviours via distinct neurochemical mechanism. We therefore examined cocaine- and morphine-induced locomotion stimulation, sensitisation and conditioned place preference (CPP) as well as alcohol intake. The 3-chambered box was utilised to investigate social behaviours.Cocaine and morphine enhanced the locomotor activity in 1a KO mice but not in 1b KO and WT mice. However, cocaine- and morphine-induced CPP was unaffected by either isoform deletion. Conversely, while WT and 1a KO mice extinguished alcohol preference during withdrawal, this was not seen in 1b KO mice. Finally, 1a KO mice exhibited higher social novelty preference and striatal oxytocin receptor levels compared to WT and 1b KO mice. These results reveal that presynaptic preferring GABAB(1a) receptors selectively modulate the psychomotor effects of cocaine and morphine as well as social novelty, most likely by inhibiting dopaminergic transmission. Conversely, the postsynaptic GABAB(1b) receptors may play a larger role in alcohol addiction. We conclude that targeting GABAB receptor isoforms may constitute an effective approach to drug addiction treatment" @default.
- W2796478082 created "2018-04-24" @default.
- W2796478082 creator A5047864906 @default.
- W2796478082 date "2018-02-28" @default.
- W2796478082 modified "2023-09-29" @default.
- W2796478082 title "The role of GABAB in drug addiction" @default.
- W2796478082 hasPublicationYear "2018" @default.
- W2796478082 type Work @default.
- W2796478082 sameAs 2796478082 @default.
- W2796478082 citedByCount "0" @default.
- W2796478082 crossrefType "dissertation" @default.
- W2796478082 hasAuthorship W2796478082A5047864906 @default.
- W2796478082 hasConcept C101027131 @default.
- W2796478082 hasConcept C15744967 @default.
- W2796478082 hasConcept C169760540 @default.
- W2796478082 hasConcept C170493617 @default.
- W2796478082 hasConcept C185592680 @default.
- W2796478082 hasConcept C25876315 @default.
- W2796478082 hasConcept C2778938600 @default.
- W2796478082 hasConcept C2779177108 @default.
- W2796478082 hasConcept C2781201050 @default.
- W2796478082 hasConcept C513476851 @default.
- W2796478082 hasConcept C55493867 @default.
- W2796478082 hasConcept C86803240 @default.
- W2796478082 hasConcept C98274493 @default.
- W2796478082 hasConceptScore W2796478082C101027131 @default.
- W2796478082 hasConceptScore W2796478082C15744967 @default.
- W2796478082 hasConceptScore W2796478082C169760540 @default.
- W2796478082 hasConceptScore W2796478082C170493617 @default.
- W2796478082 hasConceptScore W2796478082C185592680 @default.
- W2796478082 hasConceptScore W2796478082C25876315 @default.
- W2796478082 hasConceptScore W2796478082C2778938600 @default.
- W2796478082 hasConceptScore W2796478082C2779177108 @default.
- W2796478082 hasConceptScore W2796478082C2781201050 @default.
- W2796478082 hasConceptScore W2796478082C513476851 @default.
- W2796478082 hasConceptScore W2796478082C55493867 @default.
- W2796478082 hasConceptScore W2796478082C86803240 @default.
- W2796478082 hasConceptScore W2796478082C98274493 @default.
- W2796478082 hasLocation W27964780821 @default.
- W2796478082 hasOpenAccess W2796478082 @default.
- W2796478082 hasPrimaryLocation W27964780821 @default.
- W2796478082 hasRelatedWork W1867835289 @default.
- W2796478082 hasRelatedWork W1943617409 @default.
- W2796478082 hasRelatedWork W1971711035 @default.
- W2796478082 hasRelatedWork W1983333202 @default.
- W2796478082 hasRelatedWork W2028310558 @default.
- W2796478082 hasRelatedWork W2031687986 @default.
- W2796478082 hasRelatedWork W2060807424 @default.
- W2796478082 hasRelatedWork W2061313081 @default.
- W2796478082 hasRelatedWork W2064667951 @default.
- W2796478082 hasRelatedWork W2085749739 @default.
- W2796478082 hasRelatedWork W2102429943 @default.
- W2796478082 hasRelatedWork W2107608518 @default.
- W2796478082 hasRelatedWork W2108856429 @default.
- W2796478082 hasRelatedWork W2119038150 @default.
- W2796478082 hasRelatedWork W2131265661 @default.
- W2796478082 hasRelatedWork W2530978134 @default.
- W2796478082 hasRelatedWork W2606895480 @default.
- W2796478082 hasRelatedWork W2944334098 @default.
- W2796478082 hasRelatedWork W3024712717 @default.
- W2796478082 hasRelatedWork W3173014277 @default.
- W2796478082 isParatext "false" @default.
- W2796478082 isRetracted "false" @default.
- W2796478082 magId "2796478082" @default.
- W2796478082 workType "dissertation" @default.