Matches in SemOpenAlex for { <https://semopenalex.org/work/W2796517102> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2796517102 abstract "Introduction The proteoglycan aggrecan is a major component of the cartilaginous matrices which provides resistance against compressive forces. Spontaneously occurring functional null mutations in the aggrecan gene (Acan) in various species lead to perinatal chondrodysplasia. The aim of the present study was to investigate the cellular and biomechanical properties of the cartilaginous growth plate, and the development of intervertebral disc in a novel, experimentally induced aggrecan mutant mouse strain carrying an insertion in exon 5 of the Acan gene. Methods The novel aggrecan mutant mice were generated by inserting a loxP site into exon 5 (E5i) by homologous recombination in ES cells. Wild type and homozygous mutant (Acan-E5i/E5i) mice were analyzed by skeletal staining, histology and immunohistochemistry. Proliferation and survival were assessed by phosphorylated histone H3 immunostaining and TUNEL assay, respectively. Shape index (SI) in the proliferative zone (PZ) of the growth plate (GP) was calcul..." @default.
- W2796517102 created "2018-04-24" @default.
- W2796517102 creator A5011952801 @default.
- W2796517102 creator A5024692539 @default.
- W2796517102 creator A5034652400 @default.
- W2796517102 creator A5041556302 @default.
- W2796517102 creator A5048298647 @default.
- W2796517102 creator A5053261181 @default.
- W2796517102 creator A5063306362 @default.
- W2796517102 creator A5082575970 @default.
- W2796517102 date "2018-04-12" @default.
- W2796517102 modified "2023-09-23" @default.
- W2796517102 title "AGGRECAN DEFICIENCY RESULTS IN A STIFF CARTILAGE MATRIX AND IMPAIRS SKELETAL GROWTH BY AFFECTING CHONDROCYTE SHAPE AND COLUMNAR ELONGATION IN THE GROWTH PLATE" @default.
- W2796517102 hasPublicationYear "2018" @default.
- W2796517102 type Work @default.
- W2796517102 sameAs 2796517102 @default.
- W2796517102 citedByCount "0" @default.
- W2796517102 crossrefType "journal-article" @default.
- W2796517102 hasAuthorship W2796517102A5011952801 @default.
- W2796517102 hasAuthorship W2796517102A5024692539 @default.
- W2796517102 hasAuthorship W2796517102A5034652400 @default.
- W2796517102 hasAuthorship W2796517102A5041556302 @default.
- W2796517102 hasAuthorship W2796517102A5048298647 @default.
- W2796517102 hasAuthorship W2796517102A5053261181 @default.
- W2796517102 hasAuthorship W2796517102A5063306362 @default.
- W2796517102 hasAuthorship W2796517102A5082575970 @default.
- W2796517102 hasConcept C104317684 @default.
- W2796517102 hasConcept C105702510 @default.
- W2796517102 hasConcept C142724271 @default.
- W2796517102 hasConcept C143065580 @default.
- W2796517102 hasConcept C153911025 @default.
- W2796517102 hasConcept C17938293 @default.
- W2796517102 hasConcept C185592680 @default.
- W2796517102 hasConcept C189165786 @default.
- W2796517102 hasConcept C197534660 @default.
- W2796517102 hasConcept C203014093 @default.
- W2796517102 hasConcept C204232928 @default.
- W2796517102 hasConcept C204787440 @default.
- W2796517102 hasConcept C2776164576 @default.
- W2796517102 hasConcept C2780550940 @default.
- W2796517102 hasConcept C2781013607 @default.
- W2796517102 hasConcept C2781403057 @default.
- W2796517102 hasConcept C3020332539 @default.
- W2796517102 hasConcept C4224716 @default.
- W2796517102 hasConcept C55493867 @default.
- W2796517102 hasConcept C71924100 @default.
- W2796517102 hasConcept C86803240 @default.
- W2796517102 hasConcept C95444343 @default.
- W2796517102 hasConceptScore W2796517102C104317684 @default.
- W2796517102 hasConceptScore W2796517102C105702510 @default.
- W2796517102 hasConceptScore W2796517102C142724271 @default.
- W2796517102 hasConceptScore W2796517102C143065580 @default.
- W2796517102 hasConceptScore W2796517102C153911025 @default.
- W2796517102 hasConceptScore W2796517102C17938293 @default.
- W2796517102 hasConceptScore W2796517102C185592680 @default.
- W2796517102 hasConceptScore W2796517102C189165786 @default.
- W2796517102 hasConceptScore W2796517102C197534660 @default.
- W2796517102 hasConceptScore W2796517102C203014093 @default.
- W2796517102 hasConceptScore W2796517102C204232928 @default.
- W2796517102 hasConceptScore W2796517102C204787440 @default.
- W2796517102 hasConceptScore W2796517102C2776164576 @default.
- W2796517102 hasConceptScore W2796517102C2780550940 @default.
- W2796517102 hasConceptScore W2796517102C2781013607 @default.
- W2796517102 hasConceptScore W2796517102C2781403057 @default.
- W2796517102 hasConceptScore W2796517102C3020332539 @default.
- W2796517102 hasConceptScore W2796517102C4224716 @default.
- W2796517102 hasConceptScore W2796517102C55493867 @default.
- W2796517102 hasConceptScore W2796517102C71924100 @default.
- W2796517102 hasConceptScore W2796517102C86803240 @default.
- W2796517102 hasConceptScore W2796517102C95444343 @default.
- W2796517102 hasLocation W27965171021 @default.
- W2796517102 hasOpenAccess W2796517102 @default.
- W2796517102 hasPrimaryLocation W27965171021 @default.
- W2796517102 hasRelatedWork W1964030362 @default.
- W2796517102 hasRelatedWork W1990185161 @default.
- W2796517102 hasRelatedWork W2003771023 @default.
- W2796517102 hasRelatedWork W2011810078 @default.
- W2796517102 hasRelatedWork W2031904484 @default.
- W2796517102 hasRelatedWork W2057928544 @default.
- W2796517102 hasRelatedWork W2059508807 @default.
- W2796517102 hasRelatedWork W2070725728 @default.
- W2796517102 hasRelatedWork W2099128769 @default.
- W2796517102 hasRelatedWork W2102469224 @default.
- W2796517102 hasRelatedWork W2157936237 @default.
- W2796517102 hasRelatedWork W2166027825 @default.
- W2796517102 hasRelatedWork W2170405507 @default.
- W2796517102 hasRelatedWork W2304802479 @default.
- W2796517102 hasRelatedWork W2352404616 @default.
- W2796517102 hasRelatedWork W2355157560 @default.
- W2796517102 hasRelatedWork W2409999075 @default.
- W2796517102 hasRelatedWork W2624871477 @default.
- W2796517102 hasRelatedWork W3020791647 @default.
- W2796517102 hasRelatedWork W598225946 @default.
- W2796517102 isParatext "false" @default.
- W2796517102 isRetracted "false" @default.
- W2796517102 magId "2796517102" @default.
- W2796517102 workType "article" @default.