Matches in SemOpenAlex for { <https://semopenalex.org/work/W2796526222> ?p ?o ?g. }
- W2796526222 endingPage "3583" @default.
- W2796526222 startingPage "3576" @default.
- W2796526222 abstract "1,4-Disubstituted-1,2,3-triazole (Tz) is widely used in peptides as a trans-amide bond mimic, despite having hazardous effects on the native peptide activity. The impact of amide bond substitution by Tz on peptide secondary structures is scarcely documented. We performed a Tz scan, by systematically replacing peptide bonds following the Aib residues with Tz on two model peptaibols: alamethicin F50/5 and bergofungin D, which adopt stable α- and 310 helices, respectively. We observed that the Tz insertion, whatever its position in the peptide sequences, abolished their antimicrobial activity. The structural consequences of this insertion were further investigated using CD, NMR and X-ray diffraction. Importantly, five crystal structures that were incorporated with Tz were solved, showing various degrees of alteration of the helical structures, from minor structural perturbation of the helix to partial disorder. Together, these results showed that Tz insertions impair helical secondary structures." @default.
- W2796526222 created "2018-04-24" @default.
- W2796526222 creator A5018314967 @default.
- W2796526222 creator A5029355809 @default.
- W2796526222 creator A5031715781 @default.
- W2796526222 creator A5050626998 @default.
- W2796526222 creator A5052978566 @default.
- W2796526222 creator A5057190068 @default.
- W2796526222 creator A5066887023 @default.
- W2796526222 creator A5072843336 @default.
- W2796526222 creator A5083677303 @default.
- W2796526222 creator A5084018438 @default.
- W2796526222 date "2018-01-01" @default.
- W2796526222 modified "2023-10-15" @default.
- W2796526222 title "How are 1,2,3-triazoles accommodated in helical secondary structures?" @default.
- W2796526222 cites W1058356029 @default.
- W2796526222 cites W1428992184 @default.
- W2796526222 cites W1480294535 @default.
- W2796526222 cites W1539735559 @default.
- W2796526222 cites W1966193246 @default.
- W2796526222 cites W1968122720 @default.
- W2796526222 cites W1968652549 @default.
- W2796526222 cites W1978067561 @default.
- W2796526222 cites W1981535368 @default.
- W2796526222 cites W1987647341 @default.
- W2796526222 cites W1997384934 @default.
- W2796526222 cites W2002212889 @default.
- W2796526222 cites W2012655453 @default.
- W2796526222 cites W2014911335 @default.
- W2796526222 cites W2015235532 @default.
- W2796526222 cites W2023858974 @default.
- W2796526222 cites W2031695819 @default.
- W2796526222 cites W2034622752 @default.
- W2796526222 cites W2044231120 @default.
- W2796526222 cites W2047620716 @default.
- W2796526222 cites W2049799320 @default.
- W2796526222 cites W2056894945 @default.
- W2796526222 cites W2057256709 @default.
- W2796526222 cites W2057563075 @default.
- W2796526222 cites W2064401195 @default.
- W2796526222 cites W2065514881 @default.
- W2796526222 cites W2067136873 @default.
- W2796526222 cites W2075018074 @default.
- W2796526222 cites W2084343368 @default.
- W2796526222 cites W2085313140 @default.
- W2796526222 cites W2093388732 @default.
- W2796526222 cites W2122131445 @default.
- W2796526222 cites W2125245624 @default.
- W2796526222 cites W2125604156 @default.
- W2796526222 cites W2133131329 @default.
- W2796526222 cites W2133857972 @default.
- W2796526222 cites W2135255289 @default.
- W2796526222 cites W2135641931 @default.
- W2796526222 cites W2138050728 @default.
- W2796526222 cites W2142718340 @default.
- W2796526222 cites W2156459143 @default.
- W2796526222 cites W2157796847 @default.
- W2796526222 cites W2165604177 @default.
- W2796526222 cites W2276264514 @default.
- W2796526222 cites W2318894772 @default.
- W2796526222 cites W2331317066 @default.
- W2796526222 cites W2582674320 @default.
- W2796526222 cites W2754322660 @default.
- W2796526222 cites W4231340065 @default.
- W2796526222 cites W4239456141 @default.
- W2796526222 cites W4256503849 @default.
- W2796526222 doi "https://doi.org/10.1039/c8ob00686e" @default.
- W2796526222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29693098" @default.
- W2796526222 hasPublicationYear "2018" @default.
- W2796526222 type Work @default.
- W2796526222 sameAs 2796526222 @default.
- W2796526222 citedByCount "18" @default.
- W2796526222 countsByYear W27965262222018 @default.
- W2796526222 countsByYear W27965262222019 @default.
- W2796526222 countsByYear W27965262222020 @default.
- W2796526222 countsByYear W27965262222021 @default.
- W2796526222 countsByYear W27965262222022 @default.
- W2796526222 countsByYear W27965262222023 @default.
- W2796526222 crossrefType "journal-article" @default.
- W2796526222 hasAuthorship W2796526222A5018314967 @default.
- W2796526222 hasAuthorship W2796526222A5029355809 @default.
- W2796526222 hasAuthorship W2796526222A5031715781 @default.
- W2796526222 hasAuthorship W2796526222A5050626998 @default.
- W2796526222 hasAuthorship W2796526222A5052978566 @default.
- W2796526222 hasAuthorship W2796526222A5057190068 @default.
- W2796526222 hasAuthorship W2796526222A5066887023 @default.
- W2796526222 hasAuthorship W2796526222A5072843336 @default.
- W2796526222 hasAuthorship W2796526222A5083677303 @default.
- W2796526222 hasAuthorship W2796526222A5084018438 @default.
- W2796526222 hasConcept C115624301 @default.
- W2796526222 hasConcept C170493617 @default.
- W2796526222 hasConcept C178790620 @default.
- W2796526222 hasConcept C185592680 @default.
- W2796526222 hasConcept C18903297 @default.
- W2796526222 hasConcept C2778439535 @default.
- W2796526222 hasConcept C2778530040 @default.
- W2796526222 hasConcept C2779281246 @default.
- W2796526222 hasConcept C2779965526 @default.