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• W2796546352 abstract "Brain-wide and genome-wide association (BW-GWA) study is presented in this paper to identify the associations between the brain imaging phenotypes (i.e., regional volumetric measures) and the genetic variants [i.e., single nucleotide polymorphism (SNP)] in Alzheimer's disease (AD). The main challenges of this study include the data heterogeneity, complex phenotype-genotype associations, high-dimensional data (e.g., thousands of SNPs), and the existence of phenotype outliers. Previous BW-GWA studies, while addressing some of these challenges, did not consider the diagnostic label information in their formulations, thus limiting their clinical applicability. To address these issues, we present a novel joint projection and sparse regression model to discover the associations between the phenotypes and genotypes. Specifically, to alleviate the negative influence of data heterogeneity, we first map the genotypes into an intermediate imaging-phenotype-like space. Then, to better reveal the complex phenotype-genotype associations, we project both the mapped genotypes and the original imaging phenotypes into a diagnostic-label-guided joint feature space, where the intraclass projected points are constrained to be close to each other. In addition, we use l2,1-norm minimization on both the regression loss function and the transformation coefficient matrices, to reduce the effect of phenotype outliers and also to encourage sparse feature selections of both the genotypes and phenotypes. We evaluate our method using AD neuroimaging initiative dataset, and the results show that our proposed method outperforms several state-of-the-art methods in term of the average root-mean-square error of genome-to-phenotype predictions. Besides, the associated SNPs and brain regions identified in this study have also been shown in the previous AD-related studies, thus verifying the effectiveness and potential of our proposed method in AD pathogenesis study." @default.
• W2796546352 created "2018-04-24" @default.
• W2796546352 creator A5000937401 @default.
• W2796546352 creator A5050560717 @default.
• W2796546352 creator A5061274720 @default.
• W2796546352 creator A5075744244 @default.
• W2796546352 date "2019-01-01" @default.
• W2796546352 modified "2023-10-15" @default.
• W2796546352 title "Brain-Wide Genome-Wide Association Study for Alzheimer's Disease via Joint Projection Learning and Sparse Regression Model" @default.
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• W2796546352 doi "https://doi.org/10.1109/tbme.2018.2824725" @default.
• W2796546352 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6342004" @default.
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• W2796546352 hasPublicationYear "2019" @default.
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