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- W2796603948 abstract "ABSTRACT RNases are key enzymes involved in RNA maturation and degradation. Although they play a crucial role in all domains of life, bacteria, archaea, and eukaryotes have evolved with their own sets of RNases and proteins modulating their activities. In bacteria, these enzymes allow modulation of gene expression to adapt to rapidly changing environments. Today, >20 RNases have been identified in both Escherichia coli and Bacillus subtilis , the paradigms of the Gram-negative and Gram-positive bacteria, respectively. However, only a handful of these enzymes are common to these two organisms and some of them are essential to only one. Moreover, although sets of RNases can be very similar in closely related bacteria such as the Firmicutes Staphylococcus aureus and B. subtilis , the relative importance of individual enzymes in posttranscriptional regulation in these organisms varies. In this review, we detail the role of the main RNases involved in RNA maturation and degradation in Gram-positive bacteria, with an emphasis on the roles of RNase J1, RNase III, and RNase Y. We also discuss how other proteins such as helicases can modulate the RNA-degradation activities of these enzymes." @default.
- W2796603948 created "2018-04-24" @default.
- W2796603948 creator A5013104317 @default.
- W2796603948 creator A5053310572 @default.
- W2796603948 date "2018-04-06" @default.
- W2796603948 modified "2023-10-17" @default.
- W2796603948 title "RNases and Helicases in Gram-Positive Bacteria" @default.
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- W2796603948 doi "https://doi.org/10.1128/microbiolspec.rwr-0003-2017" @default.
- W2796603948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29651979" @default.
- W2796603948 hasPublicationYear "2018" @default.
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