Matches in SemOpenAlex for { <https://semopenalex.org/work/W2796605220> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2796605220 endingPage "1142" @default.
- W2796605220 startingPage "1135" @default.
- W2796605220 abstract "This study assessed healthcare costs of first-line treatment failure (TF) in patients with chronic lymphocytic leukemia (CLL), a subtype of non-Hodgkin's lymphoma.Pre-diagnosis treatment-naïve adults with ≥2 CLL diagnoses initiated on an antineoplastic agent (index date) after their first CLL diagnosis with ≥12 and ≥6 months of continuous observation pre- and post-index, respectively, were selected from the Truven Health MarketScan Research Databases. Patients had no solid malignancies in the pre-index period nor selected blood malignancies at any time. Initial therapy included antineoplastic agents initiated in the first 30 days post-index. TF occurred at the earliest of: initiation of a new antineoplastic agent, treatment resumption following a ≥3 month break, non-chemotherapy intervention (stem cell transplant or radiotherapy), hospice care or hospital mortality. The cost of TF was evaluated as the healthcare cost difference between patients with and without first-line TF using ordinary least square regressions adjusted for baseline characteristics. Non-parametric bootstrap was used to evaluate statistical significance.Among 2226 patients identified (mean age: 68 years; female: 41%), 46% experienced first-line TF. The average TF cost was $3011 per patient per month (p < .001). When stratifying patients by event indicating TF and by most common therapies, non-chemotherapy intervention ($7582 per patient per month; p < .0001) and fludarabine/cyclophosphamide/rituximab ($4758; p < .001) were associated with the highest TF cost, respectively.The cost of first-line TF is high and varies across first-line therapies. This should be considered when selecting the initial therapy in these patients." @default.
- W2796605220 created "2018-04-24" @default.
- W2796605220 creator A5010247995 @default.
- W2796605220 creator A5012473008 @default.
- W2796605220 creator A5019269759 @default.
- W2796605220 creator A5019906660 @default.
- W2796605220 creator A5076735010 @default.
- W2796605220 creator A5083172350 @default.
- W2796605220 date "2018-04-25" @default.
- W2796605220 modified "2023-09-23" @default.
- W2796605220 title "Economic burden of treatment failure in chronic lymphocytic leukemia patients" @default.
- W2796605220 cites W1972744813 @default.
- W2796605220 cites W1986122954 @default.
- W2796605220 cites W1995945562 @default.
- W2796605220 cites W2000445173 @default.
- W2796605220 cites W2013320416 @default.
- W2796605220 cites W2061326496 @default.
- W2796605220 cites W2115918777 @default.
- W2796605220 cites W2121091583 @default.
- W2796605220 cites W2129645782 @default.
- W2796605220 cites W2136951425 @default.
- W2796605220 cites W2151177887 @default.
- W2796605220 cites W2154483920 @default.
- W2796605220 cites W2163348695 @default.
- W2796605220 cites W2181233858 @default.
- W2796605220 cites W2233614027 @default.
- W2796605220 cites W2604765845 @default.
- W2796605220 cites W4251009301 @default.
- W2796605220 doi "https://doi.org/10.1080/03007995.2018.1464904" @default.
- W2796605220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29649904" @default.
- W2796605220 hasPublicationYear "2018" @default.
- W2796605220 type Work @default.
- W2796605220 sameAs 2796605220 @default.
- W2796605220 citedByCount "4" @default.
- W2796605220 countsByYear W27966052202020 @default.
- W2796605220 countsByYear W27966052202021 @default.
- W2796605220 countsByYear W27966052202022 @default.
- W2796605220 crossrefType "journal-article" @default.
- W2796605220 hasAuthorship W2796605220A5010247995 @default.
- W2796605220 hasAuthorship W2796605220A5012473008 @default.
- W2796605220 hasAuthorship W2796605220A5019269759 @default.
- W2796605220 hasAuthorship W2796605220A5019906660 @default.
- W2796605220 hasAuthorship W2796605220A5076735010 @default.
- W2796605220 hasAuthorship W2796605220A5083172350 @default.
- W2796605220 hasConcept C126322002 @default.
- W2796605220 hasConcept C143998085 @default.
- W2796605220 hasConcept C2776694085 @default.
- W2796605220 hasConcept C2776755627 @default.
- W2796605220 hasConcept C2777938653 @default.
- W2796605220 hasConcept C2778461978 @default.
- W2796605220 hasConcept C2779263901 @default.
- W2796605220 hasConcept C2779338263 @default.
- W2796605220 hasConcept C2780653079 @default.
- W2796605220 hasConcept C71924100 @default.
- W2796605220 hasConceptScore W2796605220C126322002 @default.
- W2796605220 hasConceptScore W2796605220C143998085 @default.
- W2796605220 hasConceptScore W2796605220C2776694085 @default.
- W2796605220 hasConceptScore W2796605220C2776755627 @default.
- W2796605220 hasConceptScore W2796605220C2777938653 @default.
- W2796605220 hasConceptScore W2796605220C2778461978 @default.
- W2796605220 hasConceptScore W2796605220C2779263901 @default.
- W2796605220 hasConceptScore W2796605220C2779338263 @default.
- W2796605220 hasConceptScore W2796605220C2780653079 @default.
- W2796605220 hasConceptScore W2796605220C71924100 @default.
- W2796605220 hasIssue "6" @default.
- W2796605220 hasLocation W27966052201 @default.
- W2796605220 hasLocation W27966052202 @default.
- W2796605220 hasOpenAccess W2796605220 @default.
- W2796605220 hasPrimaryLocation W27966052201 @default.
- W2796605220 hasRelatedWork W1969214982 @default.
- W2796605220 hasRelatedWork W2044556191 @default.
- W2796605220 hasRelatedWork W2255355553 @default.
- W2796605220 hasRelatedWork W2792230705 @default.
- W2796605220 hasRelatedWork W2801454081 @default.
- W2796605220 hasRelatedWork W2946618690 @default.
- W2796605220 hasRelatedWork W2946778466 @default.
- W2796605220 hasRelatedWork W3131584132 @default.
- W2796605220 hasRelatedWork W4296533239 @default.
- W2796605220 hasRelatedWork W4296964215 @default.
- W2796605220 hasVolume "34" @default.
- W2796605220 isParatext "false" @default.
- W2796605220 isRetracted "false" @default.
- W2796605220 magId "2796605220" @default.
- W2796605220 workType "article" @default.