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- W2796645157 abstract "Summary StatementWe have shown that integrin mRNA expression is regulated by the application of mechanical load. This indicates that mechanical loading may modify cell sensitivity to perceive further load through increased interaction with the ECM.IntroductionTendinopathies are a range of diseases characterised by pain and insidious degeneration. Although poorly understood, onset is often associated with physical activity. We have previously investigated the regulation by mechanical strain of metalloproteinase gene expression in human tenocyte in a 3D collagen matrix. Integrins are important in cellular interaction with the ECM and are reported to mediate mechanotransduction in various non-tendon tissues. We have reported that TGFbeta activation is a key player in the regulation of metalloproteinases in response to mechanical load, which may be mediated by integrins. This project aims to investigate the effect of cyclic loading and TGFbeta stimulation on integrin expression by human tenocytes, in collagen..." @default.
- W2796645157 created "2018-04-24" @default.
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- W2796645157 date "2018-02-21" @default.
- W2796645157 modified "2023-09-23" @default.
- W2796645157 title "MECHANICAL REGULATION OF INTEGRINS IN HUMAN TENOCYTES IN COLLAGEN AND FIBRIN MATRICES" @default.
- W2796645157 hasPublicationYear "2018" @default.
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