Matches in SemOpenAlex for { <https://semopenalex.org/work/W2796687384> ?p ?o ?g. }
- W2796687384 abstract "Abstract RBBP4 and RBBP7 (RBBP4/7) are highly homologous nuclear WD40 motif containing proteins widely implicated in various cancers and are valuable drug targets. They interact with multiple proteins within diverse complexes such as NuRD and PRC2, as well as histone H3 and H4 through two distinct binding sites. FOG-1, PHF6 and histone H3 bind to the top of the donut shape seven-bladed β-propeller fold, while SUZ12, MTA1 and histone H4 bind to a pocket on the side of the WD40 repeats. Here, we briefly review these six interactions and present binding assays optimized for medium to high throughput screening. These assays enable screening of RBBP4/7 toward the discovery of novel cancer therapeutics." @default.
- W2796687384 created "2018-04-24" @default.
- W2796687384 creator A5017237861 @default.
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- W2796687384 creator A5035700215 @default.
- W2796687384 creator A5046107533 @default.
- W2796687384 date "2018-04-18" @default.
- W2796687384 modified "2023-10-17" @default.
- W2796687384 title "Targeting Human Retinoblastoma Binding Protein 4 (RBBP4) and 7 (RBBP7)" @default.
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- W2796687384 doi "https://doi.org/10.1101/303537" @default.
- W2796687384 hasPublicationYear "2018" @default.
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