FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2796720608> ?p ?o ?g. }

• W2796720608 abstract "Abstract Metabolic adaptations accompanying the development of antibiotic resistance in bacteria remain poorly understood. To interrogate this relationship, we profiled the growth of lab-evolved antibiotic-resistant lineages of the opportunistic pathogen Pseudomonas aeruginosa across 190 unique carbon sources. We semi-automatically calculated growth dynamics (maximum growth density, growth rate, and time to mid-exponential phase) of over 2,800 growth curves. These data revealed that the evolution of antibiotic resistance resulted in systems-level changes to growth dynamics and metabolic phenotype. Drug-resistant lineages predominantly displayed decreased growth relative to the ancestral lineage; however, resistant lineages occasionally displayed enhanced growth on certain carbon sources, indicating that adaption to drug can provide a growth advantage in certain environments. A genome-scale metabolic network reconstruction (GENRE) of P. aeruginosa strain UCBPP-PA14 was paired with whole-genome sequencing data of one of the drug-evolved lineages to predict genes contributing to observed changes in metabolism. Finally, we experimentally validated in silico predictions to identify genes mutated in resistant P. aeruginosa affecting loss of catabolic function. Our results build upon previous mechanistic knowledge of drug-induced metabolic adaptation and provide a framework for the identification of metabolic limitations in antibiotic-resistant pathogens. Robust drug-driven changes in bacterial metabolism have the potential to be exploited to select against antibiotic-resistant populations in chronic infections." @default.
• W2796720608 created "2018-04-24" @default.
• W2796720608 creator A5000119406 @default.
• W2796720608 creator A5068628354 @default.
• W2796720608 creator A5082679030 @default.
• W2796720608 date "2018-04-18" @default.
• W2796720608 modified "2023-10-05" @default.
• W2796720608 title "Network analysis reveals differential metabolic functionality in antibiotic-resistantPseudomonas aeruginosa" @default.
• W2796720608 cites W1518907982 @default.
• W2796720608 cites W1552890707 @default.
• W2796720608 cites W1584972843 @default.
• W2796720608 cites W1630001284 @default.
• W2796720608 cites W1802199068 @default.
• W2796720608 cites W1966831828 @default.
• W2796720608 cites W1975675040 @default.
• W2796720608 cites W1983042430 @default.
• W2796720608 cites W1999396043 @default.
• W2796720608 cites W2000422480 @default.
• W2796720608 cites W2012977051 @default.
• W2796720608 cites W2031681107 @default.
• W2796720608 cites W2042759586 @default.
• W2796720608 cites W2043887558 @default.
• W2796720608 cites W2044935306 @default.
• W2796720608 cites W2045780029 @default.
• W2796720608 cites W2046385870 @default.
• W2796720608 cites W2048853985 @default.
• W2796720608 cites W2061460130 @default.
• W2796720608 cites W2063558597 @default.
• W2796720608 cites W2066286375 @default.
• W2796720608 cites W2067849157 @default.
• W2796720608 cites W2069717071 @default.
• W2796720608 cites W2075287054 @default.
• W2796720608 cites W2078355959 @default.
• W2796720608 cites W2079387508 @default.
• W2796720608 cites W2095838576 @default.
• W2796720608 cites W2096245011 @default.
• W2796720608 cites W2097293600 @default.
• W2796720608 cites W2097944090 @default.
• W2796720608 cites W2098824895 @default.
• W2796720608 cites W2105262308 @default.
• W2796720608 cites W2106527072 @default.
• W2796720608 cites W2107007801 @default.
• W2796720608 cites W2107996465 @default.
• W2796720608 cites W2112833584 @default.
• W2796720608 cites W2115941371 @default.
• W2796720608 cites W2126643167 @default.
• W2796720608 cites W2132859657 @default.
• W2796720608 cites W2132911648 @default.
• W2796720608 cites W2133425351 @default.
• W2796720608 cites W2136234126 @default.
• W2796720608 cites W2147472054 @default.
• W2796720608 cites W2149085197 @default.
• W2796720608 cites W2151023149 @default.
• W2796720608 cites W2152192970 @default.
• W2796720608 cites W2156302195 @default.
• W2796720608 cites W2156417329 @default.
• W2796720608 cites W2171692248 @default.
• W2796720608 cites W2171974757 @default.
• W2796720608 cites W2179324586 @default.
• W2796720608 cites W2345969757 @default.
• W2796720608 cites W2511099695 @default.
• W2796720608 cites W2573117263 @default.
• W2796720608 cites W2593536290 @default.
• W2796720608 cites W2594824548 @default.
• W2796720608 cites W2608638031 @default.
• W2796720608 cites W2612123156 @default.
• W2796720608 cites W2764202526 @default.
• W2796720608 cites W2792060329 @default.
• W2796720608 cites W2805191422 @default.
• W2796720608 cites W2951790853 @default.
• W2796720608 cites W2952556486 @default.
• W2796720608 cites W4250024072 @default.
• W2796720608 doi "https://doi.org/10.1101/303289" @default.
• W2796720608 hasPublicationYear "2018" @default.
• W2796720608 type Work @default.
• W2796720608 sameAs 2796720608 @default.
• W2796720608 citedByCount "0" @default.
• W2796720608 crossrefType "posted-content" @default.
• W2796720608 hasAuthorship W2796720608A5000119406 @default.
• W2796720608 hasAuthorship W2796720608A5068628354 @default.
• W2796720608 hasAuthorship W2796720608A5082679030 @default.
• W2796720608 hasBestOaLocation W27967206081 @default.
• W2796720608 hasConcept C101810790 @default.
• W2796720608 hasConcept C104317684 @default.
• W2796720608 hasConcept C114851261 @default.
• W2796720608 hasConcept C127716648 @default.
• W2796720608 hasConcept C134306372 @default.
• W2796720608 hasConcept C139807058 @default.
• W2796720608 hasConcept C141231307 @default.
• W2796720608 hasConcept C167091322 @default.
• W2796720608 hasConcept C169760540 @default.
• W2796720608 hasConcept C2775905019 @default.
• W2796720608 hasConcept C2776817793 @default.
• W2796720608 hasConcept C2777637488 @default.
• W2796720608 hasConcept C33923547 @default.
• W2796720608 hasConcept C501593827 @default.
• W2796720608 hasConcept C523546767 @default.
• W2796720608 hasConcept C54355233 @default.
• W2796720608 hasConcept C70721500 @default.
• W2796720608 hasConcept C75235859 @default.

• next