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• W2796757508 endingPage "S54" @default.
• W2796757508 startingPage "S37" @default.
• W2796757508 abstract "During the last thirty years since the discovery of endothelin-1, the therapeutic strategy that has evolved in the clinic, mainly in the treatment of pulmonary arterial hypertension, is to block the action of the peptide either at the ET(A) subtype or both receptors using orally active small molecule antagonists. Recently, there has been a rapid expansion in research targeting ET receptors using chemical entities other than small molecules, particularly monoclonal antibody antagonists and selective peptide agonists and antagonists. While usually sacrificing oral bio-availability, these compounds have other therapeutic advantages with the potential to considerably expand drug targets in the endothelin pathway and extend treatment to other pathophysiological conditions. Where the small molecule approach has been retained, a novel strategy to combine two vasoconstrictor targets, the angiotensin AT(1) receptor as well as the ET(A) receptor in the dual antagonist sparsentan has been developed. A second emerging strategy is to combine drugs that have two different targets, the ET(A) antagonist ambrisentan with the phosphodiesterase inhibitor tadalafil, to improve the treatment of pulmonary arterial hypertension. The solving of the crystal structure of the ET(B) receptor has the potential to identify allosteric binding sites for novel ligands. A further key advance is the experimental validation of a single nucleotide polymorphism that has genome wide significance in five vascular diseases and that significantly increases the amount of big endothelin-1 precursor in the plasma. This observation provides a rationale for testing this single nucleotide polymorphism to stratify patients for allocation to treatment with endothelin agents and highlights the potential to use personalized precision medicine in the endothelin field." @default.
• W2796757508 created "2018-04-24" @default.
• W2796757508 creator A5019791662 @default.
• W2796757508 creator A5021320481 @default.
• W2796757508 creator A5039959378 @default.
• W2796757508 creator A5041395035 @default.
• W2796757508 date "2018-05-06" @default.
• W2796757508 modified "2023-09-26" @default.
• W2796757508 title "New Drugs and Emerging Therapeutic Targets in the Endothelin Signaling Pathway and Prospects for Personalized Precision Medicine" @default.
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• W2796757508 doi "https://doi.org/10.33549/physiolres.933872" @default.
• W2796757508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29947527" @default.
• W2796757508 hasPublicationYear "2018" @default.
• W2796757508 type Work @default.

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