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• W279678684 abstract "Cytosol and nuclear receptors of various steroid hormones are present during the fetal life of the guinea pig; in particular, estradiol receptors are distributed among several fetal tissues. Although found in such different tissues as uterus, lung, kidney and brain, the physico-chemical properties of the fetal estradiol receptor are similar in all fetal tissues studied. Estradiol binding is of high affinity (Kd = 10−10M), is specific for estrogens, and has a sedimentation co-efficient of 8S in low salt sucrose density gradients and a pi of 6.1 - 6.2. Cytosol and nuclear estradiol receptors are present from mid-gestation (30-34 days) and their numbers increase during development in all fetal tissues studied. They decrease after birth, except in the lung where cytosol receptors continue to increase. There is, however, a vast quantitative difference in the concentrations of estradiol receptors in the various tissues; the concentration in fetal uterus (per mg DNA or per g tissue) is 10 to 100 times higher than in the other fetal tissues. Using the method of cytosol and nuclear exchange, the total number of specific binding sites in fetal uterus has been observed to reach 18–20 pmole per mg DNA of which 13% are occupied by endogenous hormone. Progesterone receptors have also been found in fetal guinea pig uterus as well as in the ovary. Unlike the estradiol receptor progesterone receptor only appears towards the end of gestation (day 50). Progesterone receptors can be induced and stimulated in fetal uterus by estrogens. It is suggested that this biological effect of estrogens on the production of the progesterone receptor protein could be involved in some aspects of fetal maturation; the physiological repercussions of this finding is to be explored." @default.
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• W279678684 date "1980-01-01" @default.
• W279678684 modified "2023-09-23" @default.
• W279678684 title "Ontogeny of Steroid Receptors in the Guinea Pig" @default.
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• W279678684 doi "https://doi.org/10.1016/b978-0-08-024940-7.50010-x" @default.
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