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• W2796863313 abstract "Cinnamon (Cinnamomum zeylanicum) bark extract exhibits potent inhibitory activity against Candida albicans but the antifungal mechanisms of this essential oil remain largely unexplored.We analyzed the impact of cinnamon bark oil on C. albicans RSY150, and clinical strains isolated from patients with candidemia and candidiasis. The viability of RSY150 was significantly compromised in a dose dependent manner when exposed to cinnamon bark oil, with extensive cell surface remodelling at sub inhibitory levels (62.5 μg/mL). Atomic force microscopy revealed cell surface exfoliation, altered ultrastructure and reduced cell wall integrity for both RSY150 and clinical isolates exposed to cinnamon bark oil. Cell wall damage induced by cinnamon bark oil was confirmed by exposure to stressors and the sensitivity of cell wall mutants involved in cell wall organization, biogenesis, and morphogenesis. The essential oil triggered cell cycle arrest by disrupting beta tubulin distribution, which led to mitotic spindle defects, ultimately compromising the cell membrane and allowing leakage of cellular components. The multiple targets of cinnamon bark oil can be attributed to its components, including cinnamaldehyde (74%), and minor components (< 6%) such as linalool (3.9%), cinamyl acetate (3.8%), α-caryophyllene (5.3%) and limonene (2%). Complete inhibition of the mitotic spindle assembly was observed in C. albicans treated with cinnamaldehyde at MIC (112 μg/mL).Since cinnamaldehyde disrupts both the cell wall and tubulin polymerization, it may serve as an effective antifungal, either by chemical modification to improve its specificity and efficacy or in combination with other antifungal drugs." @default.
• W2796863313 created "2018-04-24" @default.
• W2796863313 creator A5020619064 @default.
• W2796863313 creator A5037605964 @default.
• W2796863313 creator A5047715615 @default.
• W2796863313 creator A5062422333 @default.
• W2796863313 creator A5068580952 @default.
• W2796863313 creator A5077591465 @default.
• W2796863313 date "2018-02-09" @default.
• W2796863313 modified "2023-10-12" @default.
• W2796863313 title "Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans" @default.
• W2796863313 cites W1482998026 @default.
• W2796863313 cites W1503938960 @default.
• W2796863313 cites W1529913045 @default.
• W2796863313 cites W1649510002 @default.
• W2796863313 cites W1699130557 @default.
• W2796863313 cites W1781742152 @default.
• W2796863313 cites W1970482041 @default.
• W2796863313 cites W1979473231 @default.
• W2796863313 cites W1983919727 @default.
• W2796863313 cites W1984581661 @default.
• W2796863313 cites W1995186750 @default.
• W2796863313 cites W1995932180 @default.
• W2796863313 cites W1996380608 @default.
• W2796863313 cites W1997437177 @default.
• W2796863313 cites W1998177015 @default.
• W2796863313 cites W2001646769 @default.
• W2796863313 cites W2002051588 @default.
• W2796863313 cites W2004093637 @default.
• W2796863313 cites W2004503571 @default.
• W2796863313 cites W2005149112 @default.
• W2796863313 cites W2006497485 @default.
• W2796863313 cites W2015151816 @default.
• W2796863313 cites W2032338570 @default.
• W2796863313 cites W2038204439 @default.
• W2796863313 cites W2042770554 @default.
• W2796863313 cites W2043204154 @default.
• W2796863313 cites W2045720766 @default.
• W2796863313 cites W2046967366 @default.
• W2796863313 cites W2047425775 @default.
• W2796863313 cites W2047556863 @default.
• W2796863313 cites W2049212376 @default.
• W2796863313 cites W2057247009 @default.
• W2796863313 cites W2059470096 @default.
• W2796863313 cites W2063771413 @default.
• W2796863313 cites W2073376456 @default.
• W2796863313 cites W2075307062 @default.
• W2796863313 cites W2077324928 @default.
• W2796863313 cites W2080425942 @default.
• W2796863313 cites W2081144302 @default.
• W2796863313 cites W2085784176 @default.
• W2796863313 cites W2087016576 @default.
• W2796863313 cites W2087471835 @default.
• W2796863313 cites W2089197146 @default.
• W2796863313 cites W2094285560 @default.
• W2796863313 cites W2094684961 @default.
• W2796863313 cites W2096452928 @default.
• W2796863313 cites W2099951777 @default.
• W2796863313 cites W2102202691 @default.
• W2796863313 cites W2103103630 @default.
• W2796863313 cites W2106294781 @default.
• W2796863313 cites W2107490735 @default.
• W2796863313 cites W2110837175 @default.
• W2796863313 cites W2111818968 @default.
• W2796863313 cites W2112596069 @default.
• W2796863313 cites W2112621143 @default.
• W2796863313 cites W2115786496 @default.
• W2796863313 cites W2115984022 @default.
• W2796863313 cites W2122764079 @default.
• W2796863313 cites W2124608160 @default.
• W2796863313 cites W2124907616 @default.
• W2796863313 cites W2127997803 @default.
• W2796863313 cites W2131508520 @default.
• W2796863313 cites W2133112673 @default.
• W2796863313 cites W2135303569 @default.
• W2796863313 cites W2135741099 @default.
• W2796863313 cites W2136133971 @default.
• W2796863313 cites W2136493024 @default.
• W2796863313 cites W2138947616 @default.
• W2796863313 cites W2141493127 @default.
• W2796863313 cites W2143224181 @default.
• W2796863313 cites W2143823751 @default.
• W2796863313 cites W2143991410 @default.
• W2796863313 cites W2145483617 @default.
• W2796863313 cites W2151665495 @default.
• W2796863313 cites W2152484471 @default.
• W2796863313 cites W2154380734 @default.
• W2796863313 cites W2156701262 @default.
• W2796863313 cites W2157921051 @default.
• W2796863313 cites W2158288055 @default.
• W2796863313 cites W2158475155 @default.
• W2796863313 cites W2158530375 @default.
• W2796863313 cites W2162102216 @default.
• W2796863313 cites W2162598371 @default.
• W2796863313 cites W2162906973 @default.
• W2796863313 cites W2166344331 @default.
• W2796863313 cites W2414384904 @default.
• W2796863313 cites W2498487781 @default.
• W2796863313 cites W2761946910 @default.
• W2796863313 cites W2768017662 @default.

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