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• W2796931616 abstract "In this work, we prepared a novel composite based on hybrid gelatin carriers and montmorillonite clay (MMT) to analyze its viability as controlled drug delivery system. The objective of this research involves the characterization of composites formed by structured lipid-gelatin micro-particles (MP) and MMT clay. This analysis included the evaluation of the composite according to its rheological properties, morphology (SEM), particle size, XRD, FT-IR, and in vitro drug release. The effect of pH in the properties of the composite is evaluated. A novel raspberry-like or armor MP/MMT clay composite is reported, in which the pH has an important effect on the final structure of the composite for ad-hoc drug delivery systems. For pH values below the isoelectric point, we obtained defined morphologies with entrapment efficiencies up to 67%. The pH level controls the MP/MMT composite release mechanism, restringing drug release in the stomach-like environment. Intended for oral administration, these results evidence that the MP/MMT composite represents an attractive alternative for intestinal-colonic controlled drug delivery systems." @default.
• W2796931616 created "2018-04-24" @default.
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• W2796931616 date "2018-07-01" @default.
• W2796931616 modified "2023-10-18" @default.
• W2796931616 title "Characterization of hybrid microparticles/Montmorillonite composite with raspberry-like morphology for Atorvastatin controlled release" @default.
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• W2796931616 doi "https://doi.org/10.1016/j.colsurfb.2018.04.020" @default.
• W2796931616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29702471" @default.
• W2796931616 hasPublicationYear "2018" @default.
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