FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2796940145> ?p ?o ?g. }

• W2796940145 endingPage "363" @default.
• W2796940145 startingPage "356" @default.
• W2796940145 abstract "Recent evidence highlights the fibroblast growth factor (FGF) family in emotion modulation. Although ligands that activate FGF receptors have antidepressant and anxiolytic effects in animal models, FGF ligands have a broad range of actions both in the brain and the periphery. Therefore, identifying molecular partners that may function as allosteric modulators could offer new avenues for drug development. Since neural cell adhesion molecule (NCAM) activates FGF receptors, we asked whether peripherally administered NCAM peptide mimetics penetrate the brain and alter the behavior of standardized tests that have predictive validity for drug treatments of anxiety or depression. The NCAM peptide mimetic, plannexin, acutely increased and chronically decreased anxiety, but did not have antidepressant effects in rats. Another NCAM peptide mimetic, FGLL, had acute anxiogenic effects and chronic antidepressant effects in rats. A related NCAM peptide mimetic, FGLS, had antidepressant effects without modulating anxiety-like behavior, and these antidepressant effects were blocked by an AMPA receptor antagonist. Cisternal cerebrospinal fluid (CSF) levels of FGLs correlated with blood plasma levels in rats and non-human primates, and CSF-to-blood ratios of FGLS were comparable in both species. Results indicate that NCAM peptide mimetics penetrate the brain and support the suggestion that FGLS may be a candidate for further development as a novel treatment for major depressive disorder in humans." @default.
• W2796940145 created "2018-04-24" @default.
• W2796940145 creator A5002295424 @default.
• W2796940145 creator A5007964297 @default.
• W2796940145 creator A5049286080 @default.
• W2796940145 creator A5056450962 @default.
• W2796940145 creator A5060896975 @default.
• W2796940145 creator A5076278733 @default.
• W2796940145 creator A5090175383 @default.
• W2796940145 date "2018-04-09" @default.
• W2796940145 modified "2023-10-17" @default.
• W2796940145 title "Neural cell adhesion molecule peptide mimetics modulate emotionality: pharmacokinetic and behavioral studies in rats and non-human primates" @default.
• W2796940145 cites W1846750166 @default.
• W2796940145 cites W1963727074 @default.
• W2796940145 cites W1964160578 @default.
• W2796940145 cites W1977672375 @default.
• W2796940145 cites W1978544747 @default.
• W2796940145 cites W1978696776 @default.
• W2796940145 cites W1980795297 @default.
• W2796940145 cites W1982098988 @default.
• W2796940145 cites W1987902229 @default.
• W2796940145 cites W1989412277 @default.
• W2796940145 cites W1989864025 @default.
• W2796940145 cites W1994715141 @default.
• W2796940145 cites W2009966911 @default.
• W2796940145 cites W2011933672 @default.
• W2796940145 cites W2012321531 @default.
• W2796940145 cites W2016123696 @default.
• W2796940145 cites W2020990281 @default.
• W2796940145 cites W2022409734 @default.
• W2796940145 cites W2025927663 @default.
• W2796940145 cites W2026254165 @default.
• W2796940145 cites W2026421804 @default.
• W2796940145 cites W2026864505 @default.
• W2796940145 cites W2027557094 @default.
• W2796940145 cites W2028701653 @default.
• W2796940145 cites W2035358200 @default.
• W2796940145 cites W2048526468 @default.
• W2796940145 cites W2053247155 @default.
• W2796940145 cites W2055483044 @default.
• W2796940145 cites W2061398768 @default.
• W2796940145 cites W2064596302 @default.
• W2796940145 cites W2089299823 @default.
• W2796940145 cites W2095672805 @default.
• W2796940145 cites W2114590805 @default.
• W2796940145 cites W2140404643 @default.
• W2796940145 cites W2171960232 @default.
• W2796940145 cites W2175644944 @default.
• W2796940145 cites W2408575046 @default.
• W2796940145 cites W2522089565 @default.
• W2796940145 cites W2618618401 @default.
• W2796940145 cites W2623090940 @default.
• W2796940145 cites W2750328759 @default.
• W2796940145 doi "https://doi.org/10.1038/s41386-018-0052-6" @default.
• W2796940145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6300554" @default.
• W2796940145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29703997" @default.
• W2796940145 hasPublicationYear "2018" @default.
• W2796940145 type Work @default.
• W2796940145 sameAs 2796940145 @default.
• W2796940145 citedByCount "6" @default.
• W2796940145 countsByYear W27969401452019 @default.
• W2796940145 countsByYear W27969401452020 @default.
• W2796940145 countsByYear W27969401452021 @default.
• W2796940145 countsByYear W27969401452023 @default.
• W2796940145 crossrefType "journal-article" @default.
• W2796940145 hasAuthorship W2796940145A5002295424 @default.
• W2796940145 hasAuthorship W2796940145A5007964297 @default.
• W2796940145 hasAuthorship W2796940145A5049286080 @default.
• W2796940145 hasAuthorship W2796940145A5056450962 @default.
• W2796940145 hasAuthorship W2796940145A5060896975 @default.
• W2796940145 hasAuthorship W2796940145A5076278733 @default.
• W2796940145 hasAuthorship W2796940145A5090175383 @default.
• W2796940145 hasBestOaLocation W27969401451 @default.
• W2796940145 hasConcept C122871604 @default.
• W2796940145 hasConcept C126322002 @default.
• W2796940145 hasConcept C134018914 @default.
• W2796940145 hasConcept C1491633281 @default.
• W2796940145 hasConcept C15744967 @default.
• W2796940145 hasConcept C167305396 @default.
• W2796940145 hasConcept C169760540 @default.
• W2796940145 hasConcept C170493617 @default.
• W2796940145 hasConcept C185592680 @default.
• W2796940145 hasConcept C205044023 @default.
• W2796940145 hasConcept C2777765862 @default.
• W2796940145 hasConcept C2778875871 @default.
• W2796940145 hasConcept C2779177272 @default.
• W2796940145 hasConcept C2781161787 @default.
• W2796940145 hasConcept C55493867 @default.
• W2796940145 hasConcept C70410870 @default.
• W2796940145 hasConcept C71924100 @default.
• W2796940145 hasConcept C85789140 @default.
• W2796940145 hasConcept C98274493 @default.
• W2796940145 hasConceptScore W2796940145C122871604 @default.
• W2796940145 hasConceptScore W2796940145C126322002 @default.
• W2796940145 hasConceptScore W2796940145C134018914 @default.
• W2796940145 hasConceptScore W2796940145C1491633281 @default.
• W2796940145 hasConceptScore W2796940145C15744967 @default.
• W2796940145 hasConceptScore W2796940145C167305396 @default.

• next