FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2797006959> ?p ?o ?g. }

• W2797006959 endingPage "1172" @default.
• W2797006959 startingPage "1172" @default.
• W2797006959 abstract "Perineuronal nets (PNNs) are extracellular matrix structures surrounding neuronal sub-populations throughout the central nervous system, regulating plasticity. Enzymatically removing PNNs successfully enhances plasticity and thus functional recovery, particularly in spinal cord injury models. While PNNs within various brain regions are well studied, much of the composition and associated populations in the spinal cord is yet unknown. We aim to investigate the populations of PNN neurones involved in this functional motor recovery. Immunohistochemistry for choline acetyltransferase (labelling motoneurones), PNNs using Wisteria floribunda agglutinin (WFA) and chondroitin sulphate proteoglycans (CSPGs), including aggrecan, was performed to characterise the molecular heterogeneity of PNNs in rat spinal motoneurones (Mns). CSPG-positive PNNs surrounded ~70–80% of Mns. Using WFA, only ~60% of the CSPG-positive PNNs co-localised with WFA in the spinal Mns, while ~15–30% of Mns showed CSPG-positive but WFA-negative PNNs. Selective labelling revealed that aggrecan encircled ~90% of alpha Mns. The results indicate that (1) aggrecan labels spinal PNNs better than WFA, and (2) there are differences in PNN composition and their associated neuronal populations between the spinal cord and cortex. Insights into the role of PNNs and their molecular heterogeneity in the spinal motor pools could aid in designing targeted strategies to enhance functional recovery post-injury." @default.
• W2797006959 created "2018-04-24" @default.
• W2797006959 creator A5029239892 @default.
• W2797006959 creator A5087092839 @default.
• W2797006959 date "2018-04-12" @default.
• W2797006959 modified "2023-10-13" @default.
• W2797006959 title "Perineuronal Nets in Spinal Motoneurones: Chondroitin Sulphate Proteoglycan around Alpha Motoneurones" @default.
• W2797006959 cites W123645345 @default.
• W2797006959 cites W1501527294 @default.
• W2797006959 cites W1723871640 @default.
• W2797006959 cites W1760881456 @default.
• W2797006959 cites W1883330555 @default.
• W2797006959 cites W1917606596 @default.
• W2797006959 cites W1974815300 @default.
• W2797006959 cites W1983891257 @default.
• W2797006959 cites W1985703914 @default.
• W2797006959 cites W1997720118 @default.
• W2797006959 cites W1998880226 @default.
• W2797006959 cites W2003726233 @default.
• W2797006959 cites W2004229492 @default.
• W2797006959 cites W2012928251 @default.
• W2797006959 cites W2012993742 @default.
• W2797006959 cites W2019485533 @default.
• W2797006959 cites W2020761647 @default.
• W2797006959 cites W2022932966 @default.
• W2797006959 cites W2023383446 @default.
• W2797006959 cites W2027562987 @default.
• W2797006959 cites W2032089725 @default.
• W2797006959 cites W2033004840 @default.
• W2797006959 cites W2034163119 @default.
• W2797006959 cites W2038881167 @default.
• W2797006959 cites W2038938752 @default.
• W2797006959 cites W2045316454 @default.
• W2797006959 cites W2054505706 @default.
• W2797006959 cites W2056973871 @default.
• W2797006959 cites W2064482164 @default.
• W2797006959 cites W2065637628 @default.
• W2797006959 cites W2067627391 @default.
• W2797006959 cites W2072733897 @default.
• W2797006959 cites W2074562018 @default.
• W2797006959 cites W2074740925 @default.
• W2797006959 cites W2080442263 @default.
• W2797006959 cites W2091187766 @default.
• W2797006959 cites W2092482613 @default.
• W2797006959 cites W2095141942 @default.
• W2797006959 cites W2095511833 @default.
• W2797006959 cites W2099134671 @default.
• W2797006959 cites W2117526338 @default.
• W2797006959 cites W2125814499 @default.
• W2797006959 cites W2126017421 @default.
• W2797006959 cites W2130512993 @default.
• W2797006959 cites W2140594760 @default.
• W2797006959 cites W2158496649 @default.
• W2797006959 cites W2163617647 @default.
• W2797006959 cites W2164667485 @default.
• W2797006959 cites W2166211239 @default.
• W2797006959 cites W2167208176 @default.
• W2797006959 cites W2167279371 @default.
• W2797006959 cites W2179082886 @default.
• W2797006959 cites W2333301394 @default.
• W2797006959 cites W2335780138 @default.
• W2797006959 cites W2339345675 @default.
• W2797006959 cites W235963444 @default.
• W2797006959 cites W2531096100 @default.
• W2797006959 cites W2612023626 @default.
• W2797006959 cites W2735735043 @default.
• W2797006959 doi "https://doi.org/10.3390/ijms19041172" @default.
• W2797006959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5979458" @default.
• W2797006959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29649136" @default.
• W2797006959 hasPublicationYear "2018" @default.
• W2797006959 type Work @default.
• W2797006959 sameAs 2797006959 @default.
• W2797006959 citedByCount "26" @default.
• W2797006959 countsByYear W27970069592018 @default.
• W2797006959 countsByYear W27970069592019 @default.
• W2797006959 countsByYear W27970069592020 @default.
• W2797006959 countsByYear W27970069592021 @default.
• W2797006959 countsByYear W27970069592022 @default.
• W2797006959 countsByYear W27970069592023 @default.
• W2797006959 crossrefType "journal-article" @default.
• W2797006959 hasAuthorship W2797006959A5029239892 @default.
• W2797006959 hasAuthorship W2797006959A5087092839 @default.
• W2797006959 hasBestOaLocation W27970069591 @default.
• W2797006959 hasConcept C105702510 @default.
• W2797006959 hasConcept C129987498 @default.
• W2797006959 hasConcept C142724271 @default.
• W2797006959 hasConcept C159470946 @default.
• W2797006959 hasConcept C169760540 @default.
• W2797006959 hasConcept C189165786 @default.
• W2797006959 hasConcept C197534660 @default.
• W2797006959 hasConcept C204787440 @default.
• W2797006959 hasConcept C2775895372 @default.
• W2797006959 hasConcept C2776164576 @default.
• W2797006959 hasConcept C2778334475 @default.
• W2797006959 hasConcept C2779335624 @default.
• W2797006959 hasConcept C2780775167 @default.
• W2797006959 hasConcept C3020332539 @default.
• W2797006959 hasConcept C529278444 @default.

• next