FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2797183733> ?p ?o ?g. }

• W2797183733 endingPage "284" @default.
• W2797183733 startingPage "271" @default.
• W2797183733 abstract "Obesity is associated with the inappropriate activation of the renin-angiotensin system (RAS), which increases arterial pressure, impairs insulin secretion and decreases peripheral tissue insulin sensitivity. RAS blockade reverses these detriments; however, it is not clear whether the disease state of the organism and treatment duration determine the beneficial effects of RAS inhibition on insulin secretion and insulin sensitivity. Therefore, the objective of this study was to compare the benefits of acute vs chronic angiotensin receptor type 1 (AT 1 ) blockade started after the onset of obesity, hyperglycemia and hypertension on pancreatic function and peripheral insulin resistance. We assessed adipocyte morphology, glucose intolerance, pancreatic redox balance and insulin secretion after 2 and 11 weeks of AT 1 blockade in the following groups of rats: (1) untreated Long-Evans Tokushima Otsuka (lean control; n = 10), (2) untreated Otsuka Long-Evans Tokushima Fatty (OLETF; n = 12) and (3) OLETF + ARB (ARB; 10 mg olmesartan/kg/day by oral gavage; n = 12). Regardless of treatment duration, AT 1 blockade decreased systolic blood pressure and fasting plasma triglycerides, whereas chronic AT 1 blockade decreased fasting plasma glucose, glucose intolerance and the relative abundance of large adipocytes by 22, 36 and 70%, respectively. AT 1 blockade, however, did not improve pancreatic oxidative stress or reverse impaired insulin secretion. Collectively, these data show that AT 1 blockade after the onset of obesity, hyperglycemia and hypertension improves peripheral tissue insulin sensitivity, but cannot completely reverse the metabolic derangement characterized by impaired insulin secretion once it has been compromised." @default.
• W2797183733 created "2018-04-24" @default.
• W2797183733 creator A5027325862 @default.
• W2797183733 creator A5036162154 @default.
• W2797183733 creator A5040757849 @default.
• W2797183733 creator A5049861668 @default.
• W2797183733 creator A5059104619 @default.
• W2797183733 creator A5068036074 @default.
• W2797183733 creator A5077809872 @default.
• W2797183733 date "2018-06-01" @default.
• W2797183733 modified "2023-10-14" @default.
• W2797183733 title "Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats" @default.
• W2797183733 cites W1532542861 @default.
• W2797183733 cites W1559272971 @default.
• W2797183733 cites W1579011031 @default.
• W2797183733 cites W1587875569 @default.
• W2797183733 cites W1889713880 @default.
• W2797183733 cites W1906521011 @default.
• W2797183733 cites W1964607854 @default.
• W2797183733 cites W1964669410 @default.
• W2797183733 cites W1966608496 @default.
• W2797183733 cites W1972929467 @default.
• W2797183733 cites W1979286215 @default.
• W2797183733 cites W1981261500 @default.
• W2797183733 cites W1983054542 @default.
• W2797183733 cites W1985671788 @default.
• W2797183733 cites W1988998787 @default.
• W2797183733 cites W1990950873 @default.
• W2797183733 cites W1991182836 @default.
• W2797183733 cites W1992716613 @default.
• W2797183733 cites W1993959456 @default.
• W2797183733 cites W2002915522 @default.
• W2797183733 cites W2003447971 @default.
• W2797183733 cites W2005875226 @default.
• W2797183733 cites W2007370298 @default.
• W2797183733 cites W2007954901 @default.
• W2797183733 cites W2012719211 @default.
• W2797183733 cites W2021123982 @default.
• W2797183733 cites W2023300718 @default.
• W2797183733 cites W2024888489 @default.
• W2797183733 cites W2027637059 @default.
• W2797183733 cites W2031204813 @default.
• W2797183733 cites W2032889432 @default.
• W2797183733 cites W2033801582 @default.
• W2797183733 cites W2038107659 @default.
• W2797183733 cites W2038961236 @default.
• W2797183733 cites W2041986811 @default.
• W2797183733 cites W2042908871 @default.
• W2797183733 cites W2049752494 @default.
• W2797183733 cites W2060131049 @default.
• W2797183733 cites W2060924841 @default.
• W2797183733 cites W2070316487 @default.
• W2797183733 cites W2078923086 @default.
• W2797183733 cites W2079528819 @default.
• W2797183733 cites W2079596450 @default.
• W2797183733 cites W2085263700 @default.
• W2797183733 cites W2088910012 @default.
• W2797183733 cites W2091296420 @default.
• W2797183733 cites W2098668103 @default.
• W2797183733 cites W2100451931 @default.
• W2797183733 cites W2100496524 @default.
• W2797183733 cites W2104340865 @default.
• W2797183733 cites W2111190158 @default.
• W2797183733 cites W2113514532 @default.
• W2797183733 cites W2118723490 @default.
• W2797183733 cites W2125103862 @default.
• W2797183733 cites W2127783883 @default.
• W2797183733 cites W2129697991 @default.
• W2797183733 cites W2135615962 @default.
• W2797183733 cites W2135788465 @default.
• W2797183733 cites W2144766547 @default.
• W2797183733 cites W2145687703 @default.
• W2797183733 cites W2149680949 @default.
• W2797183733 cites W2149860530 @default.
• W2797183733 cites W2156044622 @default.
• W2797183733 cites W2156783035 @default.
• W2797183733 cites W2157371421 @default.
• W2797183733 cites W2159454185 @default.
• W2797183733 cites W2160848960 @default.
• W2797183733 cites W2161392015 @default.
• W2797183733 cites W2167471391 @default.
• W2797183733 cites W2168276527 @default.
• W2797183733 cites W2172343141 @default.
• W2797183733 cites W2317608305 @default.
• W2797183733 cites W2336833178 @default.
• W2797183733 cites W2411384485 @default.
• W2797183733 cites W2411583672 @default.
• W2797183733 cites W2588237306 @default.
• W2797183733 cites W2610204288 @default.
• W2797183733 cites W4248842722 @default.
• W2797183733 cites W4252272548 @default.
• W2797183733 cites W4376848364 @default.
• W2797183733 doi "https://doi.org/10.1530/joe-17-0678" @default.
• W2797183733 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5945211" @default.
• W2797183733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29643115" @default.
• W2797183733 hasPublicationYear "2018" @default.
• W2797183733 type Work @default.
• W2797183733 sameAs 2797183733 @default.

• next