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• W2797255280 endingPage "57" @default.
• W2797255280 startingPage "51" @default.
• W2797255280 abstract "There is consistent evidence of a cumulative relationship between childhood adversity and psychosis, with number of adversities experienced increasing the probability of psychosis onset. It is possible that genetic factors moderate the association between childhood adversity and psychosis, potentially by influencing how an individual reacts biologically and/or psychologically following exposure to adversity, in such a way as to set them off on the path to psychosis. However, identifying the specific genetic variants involved and how they interact with childhood adversity remains challenging. We examined whether the association between cumulative exposure to childhood adversity and development of psychotic disorder was moderated by the COMT Val158Met, AKT1 rs2494732 or DRD2 rs1076560 polymorphisms, known to affect dopamine levels.Participants were 285 first-presentation psychosis cases and 256 geographically-matched controls drawn from the Genetics and Psychosis (GAP) study. Childhood adversity was assessed using the Childhood Experience of Care and Abuse Questionnaire (CECA.Q) and blood- and cheek-derived genotype data were collected.Our findings revealed no main effect of COMT Val158Met, AKT1 rs2494732 and DRD2 rs1076560 polymorphisms on psychosis case status or reports of childhood adversity. Individuals reporting a history of multiple adversities were more likely to be psychosis patients than controls, regardless of their genetic risk. There was no evidence of candidate genotype by childhood adversity interactions in relation to psychosis onset.These findings did not provide evidence of a possible role of COMT Val158Met, AKT1 rs2494732 or DRD2 rs1076560 genotypes in modifying the association between childhood adversity and onset of psychosis." @default.
• W2797255280 created "2018-04-24" @default.
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• W2797255280 date "2019-03-01" @default.
• W2797255280 modified "2023-10-17" @default.
• W2797255280 title "Interaction between childhood adversity and functional polymorphisms in the dopamine pathway on first-episode psychosis" @default.
• W2797255280 cites W1498576919 @default.
• W2797255280 cites W1971404174 @default.
• W2797255280 cites W1984789704 @default.
• W2797255280 cites W1986059489 @default.
• W2797255280 cites W1991109311 @default.
• W2797255280 cites W1994521165 @default.
• W2797255280 cites W1996913292 @default.
• W2797255280 cites W1997343027 @default.
• W2797255280 cites W1999153883 @default.
• W2797255280 cites W2004570705 @default.
• W2797255280 cites W2007497521 @default.
• W2797255280 cites W2011424370 @default.
• W2797255280 cites W2011811675 @default.
• W2797255280 cites W2012007142 @default.
• W2797255280 cites W2014095642 @default.
• W2797255280 cites W2016013658 @default.
• W2797255280 cites W2017930968 @default.
• W2797255280 cites W2019910485 @default.
• W2797255280 cites W2022294375 @default.
• W2797255280 cites W2032068392 @default.
• W2797255280 cites W2032866243 @default.
• W2797255280 cites W2035037996 @default.
• W2797255280 cites W2040333240 @default.
• W2797255280 cites W2040847667 @default.
• W2797255280 cites W2041474029 @default.
• W2797255280 cites W2043161107 @default.
• W2797255280 cites W2044905780 @default.
• W2797255280 cites W2047645624 @default.
• W2797255280 cites W2049692116 @default.
• W2797255280 cites W2054856852 @default.
• W2797255280 cites W2055387469 @default.
• W2797255280 cites W2064729301 @default.
• W2797255280 cites W2065292395 @default.
• W2797255280 cites W2071090720 @default.
• W2797255280 cites W2073214657 @default.
• W2797255280 cites W2074937887 @default.
• W2797255280 cites W2087414280 @default.
• W2797255280 cites W2091349472 @default.
• W2797255280 cites W2094113525 @default.
• W2797255280 cites W2099678317 @default.
• W2797255280 cites W2100751263 @default.
• W2797255280 cites W2102014702 @default.
• W2797255280 cites W2102581653 @default.
• W2797255280 cites W2103274030 @default.
• W2797255280 cites W2107622408 @default.
• W2797255280 cites W2107840269 @default.
• W2797255280 cites W2112247320 @default.
• W2797255280 cites W2112446953 @default.
• W2797255280 cites W2113121748 @default.
• W2797255280 cites W2114552460 @default.
• W2797255280 cites W2115807273 @default.
• W2797255280 cites W2124916392 @default.
• W2797255280 cites W2128405990 @default.
• W2797255280 cites W2129024304 @default.
• W2797255280 cites W2131871863 @default.
• W2797255280 cites W2132383332 @default.
• W2797255280 cites W2132569582 @default.
• W2797255280 cites W2132971116 @default.
• W2797255280 cites W2136825675 @default.
• W2797255280 cites W2141878312 @default.
• W2797255280 cites W2142087193 @default.
• W2797255280 cites W2144035284 @default.
• W2797255280 cites W2144422782 @default.
• W2797255280 cites W2144625250 @default.
• W2797255280 cites W2146733388 @default.
• W2797255280 cites W2150255019 @default.
• W2797255280 cites W2150487922 @default.
• W2797255280 cites W2155342545 @default.
• W2797255280 cites W2158489424 @default.
• W2797255280 cites W2160113650 @default.
• W2797255280 cites W2160695817 @default.
• W2797255280 cites W2165043737 @default.
• W2797255280 cites W2171918417 @default.
• W2797255280 cites W2193273543 @default.
• W2797255280 cites W2415762599 @default.
• W2797255280 cites W2471573433 @default.
• W2797255280 cites W2486451269 @default.
• W2797255280 cites W2513402838 @default.
• W2797255280 cites W2574935400 @default.
• W2797255280 cites W2782100502 @default.
• W2797255280 cites W5374713 @default.
• W2797255280 doi "https://doi.org/10.1016/j.schres.2018.04.010" @default.

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