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- W2797264966 abstract "SummaryStarting from human musculoskeletal sarcomas, we isolated a subset of cells that display cancer stem cell properties. The control of culture conditions is crucial to enhance the isolation of this cell population.IntroductionCancer stem cells (CSCs) have emerged as the real responsible for the development, chemoresistance, and metastatic spread of different human cancers, including musculoskeletal sarcomas. However, unlike most leukemias and solid tumors, so far, data on musculoskeletal sarcomas refer to CSCs obtained from established cell lines, and only a few authors have reported on the isolation of CSCs from tissue samples [1-7]. Reasonably due to some peculiar features of mesenchymal tumors, including the lack of unique surface markers that identify tumor progenitors, there are still partial clues on the existence of a CSC population in these cancers. Here, we report the identification of putative CSCs in musculoskeletal sarcomas using the most general accepted isolation method, the sphere cult..." @default.
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- W2797264966 date "2018-02-21" @default.
- W2797264966 modified "2023-09-24" @default.
- W2797264966 title "HUMAN MUSCULOSKELETAL SARCOMAS CONTAIN A MINORITY OF PUTATIVE CANCER STEM CELLS THAT FORM SARCOSPHERES IN VITRO" @default.
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