Matches in SemOpenAlex for { <https://semopenalex.org/work/W2797299978> ?p ?o ?g. }
- W2797299978 endingPage "326.e7" @default.
- W2797299978 startingPage "312" @default.
- W2797299978 abstract "Many non-coding transcripts (ncRNA) generated by RNA polymerase II in S. cerevisiae are terminated by the Nrd1-Nab3-Sen1 complex. However, Sen1 helicase levels are surprisingly low compared with Nrd1 and Nab3, raising questions regarding how ncRNA can be terminated in an efficient and timely manner. We show that Sen1 levels increase during the S and G2 phases of the cell cycle, leading to increased termination activity of NNS. Overexpression of Sen1 or failure to modulate its abundance by ubiquitin-proteasome-mediated degradation greatly decreases cell fitness. Sen1 toxicity is suppressed by mutations in other termination factors, and NET-seq analysis shows that its overexpression leads to a decrease in ncRNA production and altered mRNA termination. We conclude that Sen1 levels are carefully regulated to prevent aberrant termination. We suggest that ncRNA levels and coding gene transcription termination are modulated by Sen1 to fulfill critical cell cycle-specific functions." @default.
- W2797299978 created "2018-04-24" @default.
- W2797299978 creator A5012676297 @default.
- W2797299978 creator A5026873052 @default.
- W2797299978 creator A5031051969 @default.
- W2797299978 creator A5054278100 @default.
- W2797299978 creator A5076721886 @default.
- W2797299978 creator A5076777748 @default.
- W2797299978 creator A5079482663 @default.
- W2797299978 date "2018-04-01" @default.
- W2797299978 modified "2023-10-17" @default.
- W2797299978 title "Cell-Cycle Modulation of Transcription Termination Factor Sen1" @default.
- W2797299978 cites W1916898367 @default.
- W2797299978 cites W1936136232 @default.
- W2797299978 cites W1963604994 @default.
- W2797299978 cites W1968193246 @default.
- W2797299978 cites W1968745867 @default.
- W2797299978 cites W1972399884 @default.
- W2797299978 cites W1976144735 @default.
- W2797299978 cites W1979249520 @default.
- W2797299978 cites W1987777159 @default.
- W2797299978 cites W1989967763 @default.
- W2797299978 cites W1991551720 @default.
- W2797299978 cites W1991965823 @default.
- W2797299978 cites W1993009001 @default.
- W2797299978 cites W1993806599 @default.
- W2797299978 cites W1995051337 @default.
- W2797299978 cites W1997988500 @default.
- W2797299978 cites W2000119161 @default.
- W2797299978 cites W2009376717 @default.
- W2797299978 cites W2013947447 @default.
- W2797299978 cites W2017886758 @default.
- W2797299978 cites W2020122212 @default.
- W2797299978 cites W2025836692 @default.
- W2797299978 cites W2027078124 @default.
- W2797299978 cites W2027242068 @default.
- W2797299978 cites W2032501207 @default.
- W2797299978 cites W2037429489 @default.
- W2797299978 cites W2045665004 @default.
- W2797299978 cites W2046754106 @default.
- W2797299978 cites W2071347544 @default.
- W2797299978 cites W2077116367 @default.
- W2797299978 cites W2079155564 @default.
- W2797299978 cites W2085567058 @default.
- W2797299978 cites W2088722891 @default.
- W2797299978 cites W2090173484 @default.
- W2797299978 cites W2095884579 @default.
- W2797299978 cites W2096215426 @default.
- W2797299978 cites W2098195130 @default.
- W2797299978 cites W2100158530 @default.
- W2797299978 cites W2100794889 @default.
- W2797299978 cites W2101559095 @default.
- W2797299978 cites W2101589880 @default.
- W2797299978 cites W2103151604 @default.
- W2797299978 cites W2107283247 @default.
- W2797299978 cites W2110621117 @default.
- W2797299978 cites W2110932617 @default.
- W2797299978 cites W2120036713 @default.
- W2797299978 cites W2120371860 @default.
- W2797299978 cites W2120588059 @default.
- W2797299978 cites W2121157346 @default.
- W2797299978 cites W2122000770 @default.
- W2797299978 cites W2122746312 @default.
- W2797299978 cites W2125433175 @default.
- W2797299978 cites W2126751115 @default.
- W2797299978 cites W2130657733 @default.
- W2797299978 cites W2132198636 @default.
- W2797299978 cites W2132744522 @default.
- W2797299978 cites W2134526812 @default.
- W2797299978 cites W2134962337 @default.
- W2797299978 cites W2140036659 @default.
- W2797299978 cites W2140402662 @default.
- W2797299978 cites W2140729960 @default.
- W2797299978 cites W2140948740 @default.
- W2797299978 cites W2140952049 @default.
- W2797299978 cites W2148951782 @default.
- W2797299978 cites W2149855651 @default.
- W2797299978 cites W2153811680 @default.
- W2797299978 cites W2157009395 @default.
- W2797299978 cites W2158789637 @default.
- W2797299978 cites W2165967649 @default.
- W2797299978 cites W2166829841 @default.
- W2797299978 cites W2167078003 @default.
- W2797299978 cites W4247114710 @default.
- W2797299978 doi "https://doi.org/10.1016/j.molcel.2018.03.010" @default.
- W2797299978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5919780" @default.
- W2797299978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29656924" @default.
- W2797299978 hasPublicationYear "2018" @default.
- W2797299978 type Work @default.
- W2797299978 sameAs 2797299978 @default.
- W2797299978 citedByCount "18" @default.
- W2797299978 countsByYear W27972999782018 @default.
- W2797299978 countsByYear W27972999782019 @default.
- W2797299978 countsByYear W27972999782020 @default.
- W2797299978 countsByYear W27972999782021 @default.
- W2797299978 countsByYear W27972999782022 @default.
- W2797299978 countsByYear W27972999782023 @default.
- W2797299978 crossrefType "journal-article" @default.