Matches in SemOpenAlex for { <https://semopenalex.org/work/W2797336411> ?p ?o ?g. }
- W2797336411 endingPage "54" @default.
- W2797336411 startingPage "37" @default.
- W2797336411 abstract "Parkinson's disease (PD) is a neurodegenerative disorder for which a greater prevalence and incidence is described in men. This suggests a protective effect of sex hormones in the brain. Therefore, steroids and drugs to treat endocrine conditions could have additional application for PD. Here, we review the protective effect of sex hormones, particularly estrogens, progesterone, androgens and dehydroepiandrosterone, in animal models of PD and also in human studies. Data also support that drugs affecting estrogen neurotransmission such as selective estrogen receptor modulators or affecting steroid metabolism with 5α-reductase inhibitors could be repositioned for treatment of PD. Sex steroids are also modulator of neurotransmission, thus they could repurposed to treat PD motor symptoms and to modulate the response to PD medication. No drug is yet available to limit PD progression. PD is a complex disease implicating multiple pathological processes and a therapeutic strategy using drugs with several mechanisms of action, such as sex steroids and endocrine drugs are interesting repositioning options for symptomatic treatment and disease-modifying activity for PD. This article is part of the Special Issue entitled ‘Drug Repurposing: old molecules, new ways to fast track drug discovery and development for CNS disorders’." @default.
- W2797336411 created "2018-04-24" @default.
- W2797336411 creator A5067064122 @default.
- W2797336411 creator A5080421244 @default.
- W2797336411 creator A5044103729 @default.
- W2797336411 date "2019-03-01" @default.
- W2797336411 modified "2023-10-16" @default.
- W2797336411 title "Repurposing sex steroids and related drugs as potential treatment for Parkinson's disease" @default.
- W2797336411 cites W1045284996 @default.
- W2797336411 cites W1479935944 @default.
- W2797336411 cites W1481480186 @default.
- W2797336411 cites W1515063135 @default.
- W2797336411 cites W1520748992 @default.
- W2797336411 cites W1598956028 @default.
- W2797336411 cites W1836969652 @default.
- W2797336411 cites W1875461343 @default.
- W2797336411 cites W1907508211 @default.
- W2797336411 cites W1937161249 @default.
- W2797336411 cites W1967544208 @default.
- W2797336411 cites W1968507832 @default.
- W2797336411 cites W1971557456 @default.
- W2797336411 cites W1971745156 @default.
- W2797336411 cites W1972821707 @default.
- W2797336411 cites W1975941800 @default.
- W2797336411 cites W1976426926 @default.
- W2797336411 cites W1977206324 @default.
- W2797336411 cites W1977827405 @default.
- W2797336411 cites W1978793506 @default.
- W2797336411 cites W1979062320 @default.
- W2797336411 cites W1979377822 @default.
- W2797336411 cites W1980202815 @default.
- W2797336411 cites W1980730998 @default.
- W2797336411 cites W1982027478 @default.
- W2797336411 cites W1985681015 @default.
- W2797336411 cites W1987111435 @default.
- W2797336411 cites W1988082908 @default.
- W2797336411 cites W1988443422 @default.
- W2797336411 cites W1988658425 @default.
- W2797336411 cites W1991468624 @default.
- W2797336411 cites W1992840778 @default.
- W2797336411 cites W1993241967 @default.
- W2797336411 cites W1993292496 @default.
- W2797336411 cites W1993790483 @default.
- W2797336411 cites W1994044142 @default.
- W2797336411 cites W1998101301 @default.
- W2797336411 cites W1998104342 @default.
- W2797336411 cites W1999217140 @default.
- W2797336411 cites W1999240163 @default.
- W2797336411 cites W1999649731 @default.
- W2797336411 cites W2001085718 @default.
- W2797336411 cites W2003593774 @default.
- W2797336411 cites W2005559221 @default.
- W2797336411 cites W2006317352 @default.
- W2797336411 cites W2015204251 @default.
- W2797336411 cites W2018651845 @default.
- W2797336411 cites W2019692075 @default.
- W2797336411 cites W2021144019 @default.
- W2797336411 cites W2023310799 @default.
- W2797336411 cites W2023710427 @default.
- W2797336411 cites W2024173595 @default.
- W2797336411 cites W2025205776 @default.
- W2797336411 cites W2026698631 @default.
- W2797336411 cites W2027548273 @default.
- W2797336411 cites W2028413098 @default.
- W2797336411 cites W2030555662 @default.
- W2797336411 cites W2031467188 @default.
- W2797336411 cites W2031740174 @default.
- W2797336411 cites W2031801873 @default.
- W2797336411 cites W2032960995 @default.
- W2797336411 cites W2033279302 @default.
- W2797336411 cites W2033616185 @default.
- W2797336411 cites W2034341467 @default.
- W2797336411 cites W2037056094 @default.
- W2797336411 cites W2037486805 @default.
- W2797336411 cites W2042430625 @default.
- W2797336411 cites W2042646526 @default.
- W2797336411 cites W2045616163 @default.
- W2797336411 cites W2046242737 @default.
- W2797336411 cites W2046960535 @default.
- W2797336411 cites W2047226712 @default.
- W2797336411 cites W2047589791 @default.
- W2797336411 cites W2048741943 @default.
- W2797336411 cites W2048995267 @default.
- W2797336411 cites W2050034414 @default.
- W2797336411 cites W2052209710 @default.
- W2797336411 cites W2055739274 @default.
- W2797336411 cites W2057394458 @default.
- W2797336411 cites W2058350561 @default.
- W2797336411 cites W2058900741 @default.
- W2797336411 cites W2061028746 @default.
- W2797336411 cites W2061631450 @default.
- W2797336411 cites W2062527143 @default.
- W2797336411 cites W2063032404 @default.
- W2797336411 cites W2063165012 @default.
- W2797336411 cites W2065275335 @default.
- W2797336411 cites W2065688422 @default.
- W2797336411 cites W2067372612 @default.
- W2797336411 cites W2068120156 @default.