FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2797344909> ?p ?o ?g. }

• W2797344909 abstract "Globally, the microbe Neisseria gonorrhoeae (NG) causes 106 million newly documented sexually transmitted infections each year. Once appropriately diagnosed, NG infections can be readily treated with antibiotics, but high-risk patients often do not return to the clinic for treatment if results are not provided at the point of care. A rapid, sensitive molecular diagnostic would help increase NG treatment and reduce the prevalence of this sexually transmitted disease. Here, we report on the design and development of a rapid, highly sensitive, paperfluidic device for point-of-care diagnosis of NG. The device integrates patient swab sample lysis, nucleic acid extraction, thermophilic helicase-dependent amplification (tHDA), an internal amplification control (NGIC), and visual lateral flow detection within an 80 min run time. Limits of NG detection for the NG/NGIC multiplex tHDA assay were determined within the device, and clinical performance was validated retroactively against qPCR-quantified patient samples in a proof-of-concept study. This paperfluidic diagnostic has a clinically relevant limit of detection of 500 NG cells per device with analytical sensitivity down to 10 NG cells per device. In triplicate testing of 40 total urethral and vaginal swab samples, the device had 95% overall sensitivity and 100% specificity, approaching current laboratory-based molecular NG diagnostics. This diagnostic platform could increase access to accurate NG diagnoses to those most in need." @default.
• W2797344909 created "2018-04-24" @default.
• W2797344909 creator A5005255971 @default.
• W2797344909 creator A5008894006 @default.
• W2797344909 creator A5013800135 @default.
• W2797344909 creator A5026462344 @default.
• W2797344909 creator A5030559982 @default.
• W2797344909 creator A5030985627 @default.
• W2797344909 creator A5053899113 @default.
• W2797344909 creator A5056540101 @default.
• W2797344909 date "2018-04-11" @default.
• W2797344909 modified "2023-09-24" @default.
• W2797344909 title "A paperfluidic platform to detect Neisseria gonorrhoeae in clinical samples" @default.
• W2797344909 cites W1968572317 @default.
• W2797344909 cites W1978007200 @default.
• W2797344909 cites W2007812930 @default.
• W2797344909 cites W2009620064 @default.
• W2797344909 cites W2014378495 @default.
• W2797344909 cites W2020678906 @default.
• W2797344909 cites W2035837466 @default.
• W2797344909 cites W2038181580 @default.
• W2797344909 cites W2048616775 @default.
• W2797344909 cites W2054233015 @default.
• W2797344909 cites W2059582970 @default.
• W2797344909 cites W2088860727 @default.
• W2797344909 cites W2099783016 @default.
• W2797344909 cites W2141832417 @default.
• W2797344909 cites W2152050085 @default.
• W2797344909 cites W2282221335 @default.
• W2797344909 cites W2282523322 @default.
• W2797344909 cites W2406322563 @default.
• W2797344909 cites W2482442996 @default.
• W2797344909 cites W2585421489 @default.
• W2797344909 cites W2616429390 @default.
• W2797344909 cites W2774156318 @default.
• W2797344909 cites W2774158031 @default.
• W2797344909 cites W4242673392 @default.
• W2797344909 cites W4294965310 @default.
• W2797344909 cites W4302359289 @default.
• W2797344909 cites W8158197 @default.
• W2797344909 doi "https://doi.org/10.1007/s10544-018-0280-x" @default.
• W2797344909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6154386" @default.
• W2797344909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29644437" @default.
• W2797344909 hasPublicationYear "2018" @default.
• W2797344909 type Work @default.
• W2797344909 sameAs 2797344909 @default.
• W2797344909 citedByCount "37" @default.
• W2797344909 countsByYear W27973449092018 @default.
• W2797344909 countsByYear W27973449092019 @default.
• W2797344909 countsByYear W27973449092020 @default.
• W2797344909 countsByYear W27973449092021 @default.
• W2797344909 countsByYear W27973449092022 @default.
• W2797344909 countsByYear W27973449092023 @default.
• W2797344909 crossrefType "journal-article" @default.
• W2797344909 hasAuthorship W2797344909A5005255971 @default.
• W2797344909 hasAuthorship W2797344909A5008894006 @default.
• W2797344909 hasAuthorship W2797344909A5013800135 @default.
• W2797344909 hasAuthorship W2797344909A5026462344 @default.
• W2797344909 hasAuthorship W2797344909A5030559982 @default.
• W2797344909 hasAuthorship W2797344909A5030985627 @default.
• W2797344909 hasAuthorship W2797344909A5053899113 @default.
• W2797344909 hasAuthorship W2797344909A5056540101 @default.
• W2797344909 hasBestOaLocation W27973449092 @default.
• W2797344909 hasConcept C119128265 @default.
• W2797344909 hasConcept C142724271 @default.
• W2797344909 hasConcept C159047783 @default.
• W2797344909 hasConcept C185592680 @default.
• W2797344909 hasConcept C203014093 @default.
• W2797344909 hasConcept C204787440 @default.
• W2797344909 hasConcept C2777391075 @default.
• W2797344909 hasConcept C2779166590 @default.
• W2797344909 hasConcept C2780367336 @default.
• W2797344909 hasConcept C2781188995 @default.
• W2797344909 hasConcept C2909633786 @default.
• W2797344909 hasConcept C43617362 @default.
• W2797344909 hasConcept C51915194 @default.
• W2797344909 hasConcept C60644358 @default.
• W2797344909 hasConcept C64841741 @default.
• W2797344909 hasConcept C71924100 @default.
• W2797344909 hasConcept C86803240 @default.
• W2797344909 hasConcept C89423630 @default.
• W2797344909 hasConceptScore W2797344909C119128265 @default.
• W2797344909 hasConceptScore W2797344909C142724271 @default.
• W2797344909 hasConceptScore W2797344909C159047783 @default.
• W2797344909 hasConceptScore W2797344909C185592680 @default.
• W2797344909 hasConceptScore W2797344909C203014093 @default.
• W2797344909 hasConceptScore W2797344909C204787440 @default.
• W2797344909 hasConceptScore W2797344909C2777391075 @default.
• W2797344909 hasConceptScore W2797344909C2779166590 @default.
• W2797344909 hasConceptScore W2797344909C2780367336 @default.
• W2797344909 hasConceptScore W2797344909C2781188995 @default.
• W2797344909 hasConceptScore W2797344909C2909633786 @default.
• W2797344909 hasConceptScore W2797344909C43617362 @default.
• W2797344909 hasConceptScore W2797344909C51915194 @default.
• W2797344909 hasConceptScore W2797344909C60644358 @default.
• W2797344909 hasConceptScore W2797344909C64841741 @default.
• W2797344909 hasConceptScore W2797344909C71924100 @default.
• W2797344909 hasConceptScore W2797344909C86803240 @default.
• W2797344909 hasConceptScore W2797344909C89423630 @default.
• W2797344909 hasFunder F4320337355 @default.

• next