Matches in SemOpenAlex for { <https://semopenalex.org/work/W2797403984> ?p ?o ?g. }
- W2797403984 abstract "Abstract Androgen signaling plays a pivotal role in spermatogenesis, but the molecular mechanisms underlying androgen action in this process are unclear. Specifically, it is unknown if the androgen receptor (AR) is expressed in germ cells. Thus it’s interesting to reveal how androgen induces differentiation of spermatogonial progenitor cells (SPCs) in the niche. Here we observed the AR is primarily expressed in pre-spermatogonia of mice 2 days post partum (dpp), absent before spermatogenesis onset, and then expressed in surrounding Sertoli cells. Then we examined a regulatory role of the AR in spermatogenesis using a SPCs-Sertoli cells co-culture system, and demonstrated that androgen negatively regulated Plzf (the gene for stemness maintenance of SPCs). Additionally, we identified Gata2 as a target of AR in Sertoli cells, and demonstrated that Wilms tumor 1 (WT1) and β1-integrin as two putative intermediate molecules to transfer differentiation signals to SPCs, which was further verified using androgen pharmacological-deprivation mice model. These results demonstrate a regulatory pattern of androgen in SPCs niche in an indirect way via multiple steps of signal transduction." @default.
- W2797403984 created "2018-04-24" @default.
- W2797403984 creator A5023553411 @default.
- W2797403984 creator A5046597133 @default.
- W2797403984 creator A5049692788 @default.
- W2797403984 creator A5050711402 @default.
- W2797403984 creator A5056789513 @default.
- W2797403984 creator A5063880073 @default.
- W2797403984 creator A5064925455 @default.
- W2797403984 creator A5067221645 @default.
- W2797403984 creator A5074087498 @default.
- W2797403984 creator A5076590305 @default.
- W2797403984 date "2018-04-09" @default.
- W2797403984 modified "2023-10-18" @default.
- W2797403984 title "Androgen Promotes Differentiation of PLZF+ Spermatogonia pool via Indirect Regulatory Pattern" @default.
- W2797403984 cites W1537089414 @default.
- W2797403984 cites W1547644997 @default.
- W2797403984 cites W1598493997 @default.
- W2797403984 cites W1822999471 @default.
- W2797403984 cites W1965813621 @default.
- W2797403984 cites W1968137637 @default.
- W2797403984 cites W1968787705 @default.
- W2797403984 cites W1971075295 @default.
- W2797403984 cites W1977601088 @default.
- W2797403984 cites W1979408407 @default.
- W2797403984 cites W1983885442 @default.
- W2797403984 cites W1988531958 @default.
- W2797403984 cites W1992411393 @default.
- W2797403984 cites W1995432285 @default.
- W2797403984 cites W1997819172 @default.
- W2797403984 cites W2000109689 @default.
- W2797403984 cites W2003819643 @default.
- W2797403984 cites W2005077411 @default.
- W2797403984 cites W2014596340 @default.
- W2797403984 cites W2021235728 @default.
- W2797403984 cites W2021497980 @default.
- W2797403984 cites W2022127993 @default.
- W2797403984 cites W2029804435 @default.
- W2797403984 cites W2030810010 @default.
- W2797403984 cites W2043198887 @default.
- W2797403984 cites W2045519522 @default.
- W2797403984 cites W2067064279 @default.
- W2797403984 cites W2081962497 @default.
- W2797403984 cites W2088144323 @default.
- W2797403984 cites W2092137884 @default.
- W2797403984 cites W2096584578 @default.
- W2797403984 cites W2098036757 @default.
- W2797403984 cites W2100548386 @default.
- W2797403984 cites W2102892939 @default.
- W2797403984 cites W2109665403 @default.
- W2797403984 cites W2115929799 @default.
- W2797403984 cites W2125360811 @default.
- W2797403984 cites W2127647846 @default.
- W2797403984 cites W2127749087 @default.
- W2797403984 cites W2128016220 @default.
- W2797403984 cites W2131271579 @default.
- W2797403984 cites W2143069486 @default.
- W2797403984 cites W2157600435 @default.
- W2797403984 cites W2158434412 @default.
- W2797403984 cites W2160920074 @default.
- W2797403984 cites W2166919456 @default.
- W2797403984 cites W2171808845 @default.
- W2797403984 cites W2312488853 @default.
- W2797403984 cites W2495630360 @default.
- W2797403984 cites W4241312108 @default.
- W2797403984 cites W4241509596 @default.
- W2797403984 cites W586868207 @default.
- W2797403984 doi "https://doi.org/10.1101/297846" @default.
- W2797403984 hasPublicationYear "2018" @default.
- W2797403984 type Work @default.
- W2797403984 sameAs 2797403984 @default.
- W2797403984 citedByCount "1" @default.
- W2797403984 countsByYear W27974039842020 @default.
- W2797403984 crossrefType "posted-content" @default.
- W2797403984 hasAuthorship W2797403984A5023553411 @default.
- W2797403984 hasAuthorship W2797403984A5046597133 @default.
- W2797403984 hasAuthorship W2797403984A5049692788 @default.
- W2797403984 hasAuthorship W2797403984A5050711402 @default.
- W2797403984 hasAuthorship W2797403984A5056789513 @default.
- W2797403984 hasAuthorship W2797403984A5063880073 @default.
- W2797403984 hasAuthorship W2797403984A5064925455 @default.
- W2797403984 hasAuthorship W2797403984A5067221645 @default.
- W2797403984 hasAuthorship W2797403984A5074087498 @default.
- W2797403984 hasAuthorship W2797403984A5076590305 @default.
- W2797403984 hasBestOaLocation W27974039841 @default.
- W2797403984 hasConcept C121608353 @default.
- W2797403984 hasConcept C123765429 @default.
- W2797403984 hasConcept C126322002 @default.
- W2797403984 hasConcept C134018914 @default.
- W2797403984 hasConcept C201750760 @default.
- W2797403984 hasConcept C2777911890 @default.
- W2797403984 hasConcept C2780192828 @default.
- W2797403984 hasConcept C2781068068 @default.
- W2797403984 hasConcept C28328180 @default.
- W2797403984 hasConcept C54355233 @default.
- W2797403984 hasConcept C61367390 @default.
- W2797403984 hasConcept C62478195 @default.
- W2797403984 hasConcept C71315377 @default.
- W2797403984 hasConcept C71924100 @default.
- W2797403984 hasConcept C86803240 @default.