FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2797434703> ?p ?o ?g. }

• W2797434703 abstract "Liraglutide, a glucagon‑like peptide‑1 receptor agonist, is an anti‑diabetic medicine associated with a reduced risk of fracture in diabetic patients. In the present study, rats with streptozotocin (STZ)‑induced diabetes and/or bilateral ovariectomy (OVX) were treated with liraglutide for eight weeks. Liraglutide treatment increased insulin secretion and managed blood glucose levels in the rats following STZ‑induced diabetes. In addition, STZ‑ and OVX‑induced reduction of femoral bone mineral density and destruction of bone microarchitecture were alleviated by liraglutide. STZ decreased, whereas OVX increased, serum osteocalcin (OC) level (a bone formation marker) and osteoblast counts in the trabecular bone. OVX, however not STZ, markedly increased the level of serum c‑terminal telopeptide of type 1 collagen (CTX‑1, a bone resorption marker) and osteoclast counts in the trabecular area. Liraglutide treatment significantly increased serum OC levels in all three osteoporotic models, however had minimal effects on osteoblast counts. Furthermore, liraglutide significantly decreased serum CTX‑1 level and osteoclast numbers in OVX and STZ+OVX rats. Furthermore, the present study examined the mRNA expression and serum concentrations of osteoprotegerin (OPG) and receptor activator of nuclear factor‑κB ligand (RANKL), and liraglutide significantly decreased the RANKL/OPG ratio compared with the untreated rats, indicating that osteoclastogenesis was inhibited by liraglutide. In summary, the results suggested that liraglutide ameliorates STZ+OVX‑induced bone deterioration in the rat model, primarily through the inhibition of osteoclastogenesis. These preliminary findings propose a potentially beneficial effect of liraglutide on the bone health of postmenopausal diabetic patients." @default.
• W2797434703 created "2018-04-24" @default.
• W2797434703 creator A5011112981 @default.
• W2797434703 creator A5032364522 @default.
• W2797434703 creator A5052675433 @default.
• W2797434703 creator A5063714093 @default.
• W2797434703 date "2018-04-10" @default.
• W2797434703 modified "2023-10-09" @default.
• W2797434703 title "Liraglutide exerts a bone‑protective effect in ovariectomized rats with streptozotocin‑induced diabetes by inhibiting osteoclastogenesis" @default.
• W2797434703 cites W1492093843 @default.
• W2797434703 cites W1506638023 @default.
• W2797434703 cites W1534645474 @default.
• W2797434703 cites W1544352279 @default.
• W2797434703 cites W1934495549 @default.
• W2797434703 cites W1973403085 @default.
• W2797434703 cites W1984821835 @default.
• W2797434703 cites W2000647744 @default.
• W2797434703 cites W2006573193 @default.
• W2797434703 cites W2009482765 @default.
• W2797434703 cites W2013068857 @default.
• W2797434703 cites W2023433343 @default.
• W2797434703 cites W2039998322 @default.
• W2797434703 cites W2056260385 @default.
• W2797434703 cites W2064367148 @default.
• W2797434703 cites W2064437324 @default.
• W2797434703 cites W2076408697 @default.
• W2797434703 cites W2090235084 @default.
• W2797434703 cites W2096425957 @default.
• W2797434703 cites W2114913346 @default.
• W2797434703 cites W2116288435 @default.
• W2797434703 cites W2123346255 @default.
• W2797434703 cites W2125637498 @default.
• W2797434703 cites W2127650366 @default.
• W2797434703 cites W2129404964 @default.
• W2797434703 cites W2141260918 @default.
• W2797434703 cites W2142162345 @default.
• W2797434703 cites W2149816668 @default.
• W2797434703 cites W2153152770 @default.
• W2797434703 cites W2330577617 @default.
• W2797434703 cites W2409390911 @default.
• W2797434703 cites W2507544731 @default.
• W2797434703 cites W897329354 @default.
• W2797434703 doi "https://doi.org/10.3892/etm.2018.6043" @default.
• W2797434703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5958780" @default.
• W2797434703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29805533" @default.
• W2797434703 hasPublicationYear "2018" @default.
• W2797434703 type Work @default.
• W2797434703 sameAs 2797434703 @default.
• W2797434703 citedByCount "13" @default.
• W2797434703 countsByYear W27974347032019 @default.
• W2797434703 countsByYear W27974347032020 @default.
• W2797434703 countsByYear W27974347032021 @default.
• W2797434703 countsByYear W27974347032023 @default.
• W2797434703 crossrefType "journal-article" @default.
• W2797434703 hasAuthorship W2797434703A5011112981 @default.
• W2797434703 hasAuthorship W2797434703A5032364522 @default.
• W2797434703 hasAuthorship W2797434703A5052675433 @default.
• W2797434703 hasAuthorship W2797434703A5063714093 @default.
• W2797434703 hasBestOaLocation W27974347031 @default.
• W2797434703 hasConcept C125870589 @default.
• W2797434703 hasConcept C126322002 @default.
• W2797434703 hasConcept C131075544 @default.
• W2797434703 hasConcept C134018914 @default.
• W2797434703 hasConcept C160160445 @default.
• W2797434703 hasConcept C170033053 @default.
• W2797434703 hasConcept C170493617 @default.
• W2797434703 hasConcept C181199279 @default.
• W2797434703 hasConcept C185592680 @default.
• W2797434703 hasConcept C202751555 @default.
• W2797434703 hasConcept C2776033226 @default.
• W2797434703 hasConcept C2776782570 @default.
• W2797434703 hasConcept C2777164284 @default.
• W2797434703 hasConcept C2777180221 @default.
• W2797434703 hasConcept C2777391703 @default.
• W2797434703 hasConcept C2778260815 @default.
• W2797434703 hasConcept C2779280383 @default.
• W2797434703 hasConcept C2779428903 @default.
• W2797434703 hasConcept C2780426850 @default.
• W2797434703 hasConcept C2781308992 @default.
• W2797434703 hasConcept C55493867 @default.
• W2797434703 hasConcept C555293320 @default.
• W2797434703 hasConcept C673006 @default.
• W2797434703 hasConcept C71924100 @default.
• W2797434703 hasConcept C8264082 @default.
• W2797434703 hasConcept C88045685 @default.
• W2797434703 hasConceptScore W2797434703C125870589 @default.
• W2797434703 hasConceptScore W2797434703C126322002 @default.
• W2797434703 hasConceptScore W2797434703C131075544 @default.
• W2797434703 hasConceptScore W2797434703C134018914 @default.
• W2797434703 hasConceptScore W2797434703C160160445 @default.
• W2797434703 hasConceptScore W2797434703C170033053 @default.
• W2797434703 hasConceptScore W2797434703C170493617 @default.
• W2797434703 hasConceptScore W2797434703C181199279 @default.
• W2797434703 hasConceptScore W2797434703C185592680 @default.
• W2797434703 hasConceptScore W2797434703C202751555 @default.
• W2797434703 hasConceptScore W2797434703C2776033226 @default.
• W2797434703 hasConceptScore W2797434703C2776782570 @default.
• W2797434703 hasConceptScore W2797434703C2777164284 @default.
• W2797434703 hasConceptScore W2797434703C2777180221 @default.
• W2797434703 hasConceptScore W2797434703C2777391703 @default.

• next