FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2797436057> ?p ?o ?g. }

• W2797436057 endingPage "13983" @default.
• W2797436057 startingPage "13976" @default.
• W2797436057 abstract "Although the suppressing effects of celastrol on hepatocellular carcinoma (HCC) have been demonstrated, evidence for the targeting of fatty acid synthetase (FASN) in the development of HCC by celastrol is still rare. In this study, the effect of celastrol on a rapid HCC model featuring co-activation of AKT/c-Met oncogenes in mice was studied. The effect of celastrol on the alpha-fetoprotein level in the liver and serum was also investigated. Protein expressions of PCNA, Ki67 and FASN in celastrol-treated AKT/c-Met HCC mice were observed. The molecular mechanism of celastrol on the AKT/c-Met signaling pathway was elucidated. The results revealed that celastrol significantly repressed the AKT/c-Met induced HCC development and down-regulated the mRNA expression of AFP in the liver and the AFP level in serum. Furthermore, the expression of proliferation-associated proteins in the HCC tissues was reduced by celastrol treatment. Moreover, the abundant steatosis that resulted from FASN accumulation in the liver in AKT/c-Met mice was also attenuated. Finally, the phosphorylation of AKT and ERK1/2 in HCC mice was repressed by celastrol treatment. Overall, our data demonstrate that celastrol exerts an antiproliferative and novel lipid-decreasing effect by targeting AKT/ERK and FASN in HCC development in vivo." @default.
• W2797436057 created "2018-04-24" @default.
• W2797436057 creator A5001484266 @default.
• W2797436057 creator A5008514175 @default.
• W2797436057 creator A5022526821 @default.
• W2797436057 creator A5052102629 @default.
• W2797436057 creator A5074734978 @default.
• W2797436057 creator A5080566282 @default.
• W2797436057 date "2018-01-01" @default.
• W2797436057 modified "2023-10-18" @default.
• W2797436057 title "Celastrol delays hepatic steatosis and carcinogenesis in a rapid AKT/c-Met-transfected hepatocellular carcinoma model<i>via</i>suppressing fatty acid synthase expression and AKT/ERK phosphorylation" @default.
• W2797436057 cites W1499879600 @default.
• W2797436057 cites W1509405108 @default.
• W2797436057 cites W1971837077 @default.
• W2797436057 cites W1983109993 @default.
• W2797436057 cites W1988963406 @default.
• W2797436057 cites W2002965548 @default.
• W2797436057 cites W2003349524 @default.
• W2797436057 cites W2006166594 @default.
• W2797436057 cites W2025148706 @default.
• W2797436057 cites W2048960913 @default.
• W2797436057 cites W2055729918 @default.
• W2797436057 cites W2061743943 @default.
• W2797436057 cites W2062684714 @default.
• W2797436057 cites W2062868705 @default.
• W2797436057 cites W2068046495 @default.
• W2797436057 cites W2074648434 @default.
• W2797436057 cites W2085949354 @default.
• W2797436057 cites W2092697214 @default.
• W2797436057 cites W2094195713 @default.
• W2797436057 cites W2099565829 @default.
• W2797436057 cites W2103850315 @default.
• W2797436057 cites W2126486896 @default.
• W2797436057 cites W2136390065 @default.
• W2797436057 cites W2137390717 @default.
• W2797436057 cites W2146781227 @default.
• W2797436057 cites W2146907709 @default.
• W2797436057 cites W2152750160 @default.
• W2797436057 cites W2153178365 @default.
• W2797436057 cites W2154155095 @default.
• W2797436057 cites W2169385554 @default.
• W2797436057 cites W2294090452 @default.
• W2797436057 cites W2379622343 @default.
• W2797436057 cites W2755768583 @default.
• W2797436057 doi "https://doi.org/10.1039/c8ra00522b" @default.
• W2797436057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35539339" @default.
• W2797436057 hasPublicationYear "2018" @default.
• W2797436057 type Work @default.
• W2797436057 sameAs 2797436057 @default.
• W2797436057 citedByCount "8" @default.
• W2797436057 countsByYear W27974360572019 @default.
• W2797436057 countsByYear W27974360572020 @default.
• W2797436057 countsByYear W27974360572023 @default.
• W2797436057 crossrefType "journal-article" @default.
• W2797436057 hasAuthorship W2797436057A5001484266 @default.
• W2797436057 hasAuthorship W2797436057A5008514175 @default.
• W2797436057 hasAuthorship W2797436057A5022526821 @default.
• W2797436057 hasAuthorship W2797436057A5052102629 @default.
• W2797436057 hasAuthorship W2797436057A5074734978 @default.
• W2797436057 hasAuthorship W2797436057A5080566282 @default.
• W2797436057 hasBestOaLocation W27974360571 @default.
• W2797436057 hasConcept C104317684 @default.
• W2797436057 hasConcept C11960822 @default.
• W2797436057 hasConcept C134018914 @default.
• W2797436057 hasConcept C185592680 @default.
• W2797436057 hasConcept C190283241 @default.
• W2797436057 hasConcept C2776175330 @default.
• W2797436057 hasConcept C2777228702 @default.
• W2797436057 hasConcept C2778019345 @default.
• W2797436057 hasConcept C48289651 @default.
• W2797436057 hasConcept C502942594 @default.
• W2797436057 hasConcept C543025807 @default.
• W2797436057 hasConcept C55493867 @default.
• W2797436057 hasConcept C555283112 @default.
• W2797436057 hasConcept C57074206 @default.
• W2797436057 hasConcept C62478195 @default.
• W2797436057 hasConcept C71924100 @default.
• W2797436057 hasConcept C75217442 @default.
• W2797436057 hasConcept C86554907 @default.
• W2797436057 hasConceptScore W2797436057C104317684 @default.
• W2797436057 hasConceptScore W2797436057C11960822 @default.
• W2797436057 hasConceptScore W2797436057C134018914 @default.
• W2797436057 hasConceptScore W2797436057C185592680 @default.
• W2797436057 hasConceptScore W2797436057C190283241 @default.
• W2797436057 hasConceptScore W2797436057C2776175330 @default.
• W2797436057 hasConceptScore W2797436057C2777228702 @default.
• W2797436057 hasConceptScore W2797436057C2778019345 @default.
• W2797436057 hasConceptScore W2797436057C48289651 @default.
• W2797436057 hasConceptScore W2797436057C502942594 @default.
• W2797436057 hasConceptScore W2797436057C543025807 @default.
• W2797436057 hasConceptScore W2797436057C55493867 @default.
• W2797436057 hasConceptScore W2797436057C555283112 @default.
• W2797436057 hasConceptScore W2797436057C57074206 @default.
• W2797436057 hasConceptScore W2797436057C62478195 @default.
• W2797436057 hasConceptScore W2797436057C71924100 @default.
• W2797436057 hasConceptScore W2797436057C75217442 @default.
• W2797436057 hasConceptScore W2797436057C86554907 @default.
• W2797436057 hasIssue "25" @default.

• next