Matches in SemOpenAlex for { <https://semopenalex.org/work/W2797460017> ?p ?o ?g. }
- W2797460017 abstract "Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in mammals, and mainly secreted and stored as a latent complex in the extracellular matrix (ECM). The biological functions of TGF-β in adults can only be delivered after ligand activation, mostly in response to environmental perturbations. Although involved in multiple biological and pathological processes of the human body, the exact roles of TGF-β in maintaining stem cells and tissue homeostasis have not been well-documented until recent advances, which delineate their functions in a given context. Our recent findings, along with data reported by others, have clearly shown that temporal and spatial activation of TGF-β is involved in the recruitment of stem/progenitor cell participation in tissue regeneration/remodeling process, whereas sustained abnormalities in TGF-β ligand activation, regardless of genetic or environmental origin, will inevitably disrupt the normal physiology and lead to pathobiology of major diseases. Modulation of TGF-β signaling with different approaches has proven effective pre-clinically in the treatment of multiple pathologies such as sclerosis/fibrosis, tumor metastasis, osteoarthritis, and immune disorders. Thus, further elucidation of the mechanisms by which TGF-β is activated in different tissues/organs and how targeted cells respond in a context-dependent way can likely be translated with clinical benefits in the management of a broad range of diseases with the involvement of TGF-β." @default.
- W2797460017 created "2018-04-24" @default.
- W2797460017 creator A5001210613 @default.
- W2797460017 creator A5003424037 @default.
- W2797460017 creator A5004698545 @default.
- W2797460017 creator A5014357890 @default.
- W2797460017 creator A5034619275 @default.
- W2797460017 creator A5045136980 @default.
- W2797460017 creator A5050458271 @default.
- W2797460017 date "2018-01-31" @default.
- W2797460017 modified "2023-10-16" @default.
- W2797460017 title "Transforming growth factor-β in stem cells and tissue homeostasis" @default.
- W2797460017 cites W113957248 @default.
- W2797460017 cites W119322828 @default.
- W2797460017 cites W121967502 @default.
- W2797460017 cites W1247235447 @default.
- W2797460017 cites W1484024717 @default.
- W2797460017 cites W1492818016 @default.
- W2797460017 cites W1494416455 @default.
- W2797460017 cites W1495319102 @default.
- W2797460017 cites W1502228398 @default.
- W2797460017 cites W1505978562 @default.
- W2797460017 cites W1515719112 @default.
- W2797460017 cites W1519258930 @default.
- W2797460017 cites W1520988136 @default.
- W2797460017 cites W1525309247 @default.
- W2797460017 cites W1528120845 @default.
- W2797460017 cites W1530583566 @default.
- W2797460017 cites W1536476892 @default.
- W2797460017 cites W1542326554 @default.
- W2797460017 cites W1547454641 @default.
- W2797460017 cites W1548494467 @default.
- W2797460017 cites W1553444759 @default.
- W2797460017 cites W1557304612 @default.
- W2797460017 cites W1560246884 @default.
- W2797460017 cites W1561938123 @default.
- W2797460017 cites W1565561072 @default.
- W2797460017 cites W1568363145 @default.
- W2797460017 cites W1575754639 @default.
- W2797460017 cites W1586474677 @default.
- W2797460017 cites W1589761009 @default.
- W2797460017 cites W1590052782 @default.
- W2797460017 cites W1606814949 @default.
- W2797460017 cites W1608791497 @default.
- W2797460017 cites W162718904 @default.
- W2797460017 cites W1639188211 @default.
- W2797460017 cites W1660743658 @default.
- W2797460017 cites W1684625763 @default.
- W2797460017 cites W1702502468 @default.
- W2797460017 cites W175318695 @default.
- W2797460017 cites W1757602702 @default.
- W2797460017 cites W1760215417 @default.
- W2797460017 cites W1796060835 @default.
- W2797460017 cites W1802397357 @default.
- W2797460017 cites W1835561921 @default.
- W2797460017 cites W1840988451 @default.
- W2797460017 cites W1859919406 @default.
- W2797460017 cites W1914634699 @default.
- W2797460017 cites W1924613311 @default.
- W2797460017 cites W1931073059 @default.
- W2797460017 cites W1934555047 @default.
- W2797460017 cites W1940496546 @default.
- W2797460017 cites W1940695087 @default.
- W2797460017 cites W1964069557 @default.
- W2797460017 cites W1964297915 @default.
- W2797460017 cites W1964780833 @default.
- W2797460017 cites W1964801456 @default.
- W2797460017 cites W1964943353 @default.
- W2797460017 cites W1965766281 @default.
- W2797460017 cites W1966177237 @default.
- W2797460017 cites W1967276782 @default.
- W2797460017 cites W1967319615 @default.
- W2797460017 cites W1967502057 @default.
- W2797460017 cites W1967518676 @default.
- W2797460017 cites W1968628080 @default.
- W2797460017 cites W1968638067 @default.
- W2797460017 cites W1968649526 @default.
- W2797460017 cites W1969604044 @default.
- W2797460017 cites W1969726379 @default.
- W2797460017 cites W1969815370 @default.
- W2797460017 cites W1970144926 @default.
- W2797460017 cites W1970564104 @default.
- W2797460017 cites W1971887776 @default.
- W2797460017 cites W1972619403 @default.
- W2797460017 cites W1973081762 @default.
- W2797460017 cites W1973426525 @default.
- W2797460017 cites W1974012180 @default.
- W2797460017 cites W1974150901 @default.
- W2797460017 cites W1974567018 @default.
- W2797460017 cites W1974606154 @default.
- W2797460017 cites W1974955986 @default.
- W2797460017 cites W1975681855 @default.
- W2797460017 cites W1975935787 @default.
- W2797460017 cites W1976001496 @default.
- W2797460017 cites W1976025099 @default.
- W2797460017 cites W1976235246 @default.
- W2797460017 cites W1976831807 @default.
- W2797460017 cites W1977437881 @default.
- W2797460017 cites W1977644273 @default.
- W2797460017 cites W1977823951 @default.