Matches in SemOpenAlex for { <https://semopenalex.org/work/W2797461445> ?p ?o ?g. }
- W2797461445 abstract "Abstract Coordinated immune responses against human tumors are frequently characterized by tertiary lymphoid structures (TLS) which predict improved prognosis. The development of TLS is dependent on the chemokine CXCL13, reported to be secreted by dendritic cells and follicular helper T cells only. We report the unexpected finding that CXCL13 is also secreted by activated CD8+ T cells following stimulation by transforming growth factor beta (TGF-β). Using single cell RNA sequencing we found that expression of CXCL13 in CD8+ T cells was restricted to the intraepithelial CD103+ population. Accordingly, CD8+ T cells activated in the presence of TGF-β simultaneously upregulated CD103 and secreted CXCL13. CXCL13 expression was strongly correlated with neo-antigen burden and cytolytic gene signatures in bulk tumors. In line with this, TLS were abundant in neo-antigen-high, CD103+ T cell-enriched tumors. TGF-β thus appears to play a role in coordinating immune responses against human tumors through CD8-dependent CXCL13-associated formation of TLS." @default.
- W2797461445 created "2018-04-24" @default.
- W2797461445 creator A5005622544 @default.
- W2797461445 creator A5016382034 @default.
- W2797461445 creator A5018546853 @default.
- W2797461445 creator A5025042206 @default.
- W2797461445 creator A5025599481 @default.
- W2797461445 creator A5046835574 @default.
- W2797461445 creator A5047110361 @default.
- W2797461445 creator A5055490369 @default.
- W2797461445 creator A5055596816 @default.
- W2797461445 creator A5063693344 @default.
- W2797461445 creator A5066875078 @default.
- W2797461445 creator A5068364166 @default.
- W2797461445 creator A5069612368 @default.
- W2797461445 creator A5070451140 @default.
- W2797461445 creator A5075073315 @default.
- W2797461445 creator A5083838208 @default.
- W2797461445 creator A5088498222 @default.
- W2797461445 creator A5090199041 @default.
- W2797461445 date "2018-04-18" @default.
- W2797461445 modified "2023-09-27" @default.
- W2797461445 title "TGF-β induced CXCL13 in CD8+ T cells is associated with tertiary lymphoid structures in cancer" @default.
- W2797461445 cites W1595770568 @default.
- W2797461445 cites W1895620535 @default.
- W2797461445 cites W1956142692 @default.
- W2797461445 cites W1966107523 @default.
- W2797461445 cites W1967800669 @default.
- W2797461445 cites W1969963445 @default.
- W2797461445 cites W1971208896 @default.
- W2797461445 cites W1982911537 @default.
- W2797461445 cites W2009629707 @default.
- W2797461445 cites W2041852726 @default.
- W2797461445 cites W2049406042 @default.
- W2797461445 cites W2050603521 @default.
- W2797461445 cites W2066671159 @default.
- W2797461445 cites W2084598886 @default.
- W2797461445 cites W2095770505 @default.
- W2797461445 cites W2098578630 @default.
- W2797461445 cites W2099761180 @default.
- W2797461445 cites W2104347254 @default.
- W2797461445 cites W2104885590 @default.
- W2797461445 cites W2112990461 @default.
- W2797461445 cites W2118771150 @default.
- W2797461445 cites W2118982164 @default.
- W2797461445 cites W2125616358 @default.
- W2797461445 cites W2147022432 @default.
- W2797461445 cites W2151252994 @default.
- W2797461445 cites W2152049148 @default.
- W2797461445 cites W2154328223 @default.
- W2797461445 cites W2160609925 @default.
- W2797461445 cites W2169410102 @default.
- W2797461445 cites W2197283606 @default.
- W2797461445 cites W2234923158 @default.
- W2797461445 cites W2252367299 @default.
- W2797461445 cites W2282311837 @default.
- W2797461445 cites W2316067769 @default.
- W2797461445 cites W2334798192 @default.
- W2797461445 cites W2339442385 @default.
- W2797461445 cites W2519636301 @default.
- W2797461445 cites W2527634451 @default.
- W2797461445 cites W2561737889 @default.
- W2797461445 cites W2566747056 @default.
- W2797461445 cites W2605792367 @default.
- W2797461445 cites W2624831627 @default.
- W2797461445 cites W2626312449 @default.
- W2797461445 cites W2753095840 @default.
- W2797461445 cites W2761575992 @default.
- W2797461445 cites W2769852564 @default.
- W2797461445 cites W2793742921 @default.
- W2797461445 cites W2795035720 @default.
- W2797461445 doi "https://doi.org/10.1101/303834" @default.
- W2797461445 hasPublicationYear "2018" @default.
- W2797461445 type Work @default.
- W2797461445 sameAs 2797461445 @default.
- W2797461445 citedByCount "1" @default.
- W2797461445 countsByYear W27974614452018 @default.
- W2797461445 crossrefType "posted-content" @default.
- W2797461445 hasAuthorship W2797461445A5005622544 @default.
- W2797461445 hasAuthorship W2797461445A5016382034 @default.
- W2797461445 hasAuthorship W2797461445A5018546853 @default.
- W2797461445 hasAuthorship W2797461445A5025042206 @default.
- W2797461445 hasAuthorship W2797461445A5025599481 @default.
- W2797461445 hasAuthorship W2797461445A5046835574 @default.
- W2797461445 hasAuthorship W2797461445A5047110361 @default.
- W2797461445 hasAuthorship W2797461445A5055490369 @default.
- W2797461445 hasAuthorship W2797461445A5055596816 @default.
- W2797461445 hasAuthorship W2797461445A5063693344 @default.
- W2797461445 hasAuthorship W2797461445A5066875078 @default.
- W2797461445 hasAuthorship W2797461445A5068364166 @default.
- W2797461445 hasAuthorship W2797461445A5069612368 @default.
- W2797461445 hasAuthorship W2797461445A5070451140 @default.
- W2797461445 hasAuthorship W2797461445A5075073315 @default.
- W2797461445 hasAuthorship W2797461445A5083838208 @default.
- W2797461445 hasAuthorship W2797461445A5088498222 @default.
- W2797461445 hasAuthorship W2797461445A5090199041 @default.
- W2797461445 hasBestOaLocation W27974614451 @default.
- W2797461445 hasConcept C12823836 @default.
- W2797461445 hasConcept C13373296 @default.
- W2797461445 hasConcept C147483822 @default.