Matches in SemOpenAlex for { <https://semopenalex.org/work/W2797497513> ?p ?o ?g. }
- W2797497513 endingPage "44" @default.
- W2797497513 startingPage "31" @default.
- W2797497513 abstract "Pancreatic cancer is among the three deadliest cancers worldwide with the lowest 5-year survival of all cancers. Despite all efforts, therapeutic improvements have barely been made over the last decade. Even recent highly promising targeted and immunotherapeutic approaches did not live up to their expectations. Therefore, other horizons have to be explored. Natural Killer (NK) cells are gaining more and more interest as a highly attractive target for cancer immunotherapies, both as pharmaceutical target and for cell therapies. In this systematic review we summarise the pathophysiological adaptions of NK cells in pancreatic cancer and highlight possible (future) therapeutic NK cell-related targets. Furthermore, an extensive overview of recent therapeutic approaches with an effect on NK cells is given, including cytokine-based, viro- and bacteriotherapy and cell therapy. We also discuss ongoing clinical trials that might influence NK cells. In conclusion, although several issues regarding NK cells in pancreatic cancer remain unsolved and need further investigation, extensive evidence is already provided that support NK cell oriented approaches in pancreatic cancer." @default.
- W2797497513 created "2018-04-24" @default.
- W2797497513 creator A5024390084 @default.
- W2797497513 creator A5026684098 @default.
- W2797497513 creator A5026944433 @default.
- W2797497513 creator A5055053148 @default.
- W2797497513 creator A5064708716 @default.
- W2797497513 creator A5069580321 @default.
- W2797497513 date "2018-09-01" @default.
- W2797497513 modified "2023-10-04" @default.
- W2797497513 title "Natural killer cells and their therapeutic role in pancreatic cancer: A systematic review" @default.
- W2797497513 cites W1045355598 @default.
- W2797497513 cites W1476467620 @default.
- W2797497513 cites W1492007834 @default.
- W2797497513 cites W1533300579 @default.
- W2797497513 cites W1541265927 @default.
- W2797497513 cites W1584501990 @default.
- W2797497513 cites W1681870720 @default.
- W2797497513 cites W1813477735 @default.
- W2797497513 cites W1847149954 @default.
- W2797497513 cites W1875592451 @default.
- W2797497513 cites W1901645063 @default.
- W2797497513 cites W1963482182 @default.
- W2797497513 cites W1965754087 @default.
- W2797497513 cites W1966183837 @default.
- W2797497513 cites W1966563663 @default.
- W2797497513 cites W1967256185 @default.
- W2797497513 cites W1970298454 @default.
- W2797497513 cites W1971994175 @default.
- W2797497513 cites W1973628993 @default.
- W2797497513 cites W1979724209 @default.
- W2797497513 cites W1980833988 @default.
- W2797497513 cites W1990046217 @default.
- W2797497513 cites W1991707690 @default.
- W2797497513 cites W1994953238 @default.
- W2797497513 cites W1995385753 @default.
- W2797497513 cites W1999102084 @default.
- W2797497513 cites W2004832984 @default.
- W2797497513 cites W2007400263 @default.
- W2797497513 cites W2011502291 @default.
- W2797497513 cites W2012530339 @default.
- W2797497513 cites W2019565242 @default.
- W2797497513 cites W2019822903 @default.
- W2797497513 cites W2020817059 @default.
- W2797497513 cites W2022310634 @default.
- W2797497513 cites W2024246831 @default.
- W2797497513 cites W2025535680 @default.
- W2797497513 cites W2033750865 @default.
- W2797497513 cites W2035035763 @default.
- W2797497513 cites W2036862386 @default.
- W2797497513 cites W2036880721 @default.
- W2797497513 cites W2039225116 @default.
- W2797497513 cites W2040038625 @default.
- W2797497513 cites W2050571295 @default.
- W2797497513 cites W2050601193 @default.
- W2797497513 cites W2070805690 @default.
- W2797497513 cites W2071462987 @default.
- W2797497513 cites W2072778294 @default.
- W2797497513 cites W2073303594 @default.
- W2797497513 cites W2073741150 @default.
- W2797497513 cites W2078802873 @default.
- W2797497513 cites W2084365384 @default.
- W2797497513 cites W2085600319 @default.
- W2797497513 cites W2086299934 @default.
- W2797497513 cites W2091799578 @default.
- W2797497513 cites W2099949742 @default.
- W2797497513 cites W2101337372 @default.
- W2797497513 cites W2103549416 @default.
- W2797497513 cites W2109302659 @default.
- W2797497513 cites W2110847485 @default.
- W2797497513 cites W2111895881 @default.
- W2797497513 cites W2112201823 @default.
- W2797497513 cites W2113655874 @default.
- W2797497513 cites W2115871745 @default.
- W2797497513 cites W2121141922 @default.
- W2797497513 cites W2125336347 @default.
- W2797497513 cites W2128510787 @default.
- W2797497513 cites W2129278872 @default.
- W2797497513 cites W2135339053 @default.
- W2797497513 cites W2140226967 @default.
- W2797497513 cites W2143518632 @default.
- W2797497513 cites W2150687804 @default.
- W2797497513 cites W2155268536 @default.
- W2797497513 cites W2157257094 @default.
- W2797497513 cites W2169620291 @default.
- W2797497513 cites W2200504328 @default.
- W2797497513 cites W2274161670 @default.
- W2797497513 cites W2309122708 @default.
- W2797497513 cites W2313204499 @default.
- W2797497513 cites W2315893838 @default.
- W2797497513 cites W2320525942 @default.
- W2797497513 cites W2321367309 @default.
- W2797497513 cites W2322747354 @default.
- W2797497513 cites W2332535881 @default.
- W2797497513 cites W2332970728 @default.
- W2797497513 cites W2336525273 @default.
- W2797497513 cites W2398759510 @default.
- W2797497513 cites W2442963418 @default.